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= Chloroxylenol =
{{Short description|Overview of the antiseptic agent Chloroxylenol}}
{{Infobox drug
| name = Chloroxylenol
| image = Chloroxylenol.svg
| width = 200px
| alt =
| caption = Chemical structure of Chloroxylenol
| tradename = Dettol, others
| class = Antiseptic
| legal_status = OTC
| routes_of_administration = Topical
| CAS_number = 88-04-0
}}


[[File:Reeva antibacterial liquid soap.jpg|thumb|right|A bottle of chloroxylenol antiseptic solution]]
'''Chloroxylenol''' is a broad-spectrum antimicrobial agent commonly used as an antiseptic and disinfectant. It is effective against a wide range of bacteria, fungi, and viruses, making it a popular choice in healthcare settings and household products.


== Introduction ==
==Chemical Properties==
'''Chloroxylenol''', commonly known by its chemical name para-chloro-meta-xylenol (PCMX), is a widely used antiseptic and disinfectant. It finds applications in both healthcare settings for skin disinfection and in household products for cleaning and sanitation.
Chloroxylenol, also known as para-chloro-meta-xylenol (PCMX), is a chlorinated phenolic compound. Its chemical formula is C<sub>8</sub>H<sub>9</sub>ClO, and it has a molecular weight of 156.61 g/mol. The compound appears as a white to off-white crystalline solid with a mild phenolic odor.


== Chemical Properties and Composition ==
==Mechanism of Action==
Chloroxylenol is a chlorinated phenolic compound. It is typically available as a colorless to pale-yellow liquid with a distinctive, somewhat phenolic odor.
Chloroxylenol works by disrupting the cell wall and membrane of microorganisms, leading to cell lysis and death. It is particularly effective against Gram-positive bacteria, although it also has activity against Gram-negative bacteria, fungi, and some viruses.


[[File:Chloroxylenol-3D-balls.png|thumb|left|Chemical structure of chloroxylenol]]
==Uses==
Chloroxylenol is widely used in various applications, including:


== Mechanism of Action ==
* '''Antiseptic Soaps and Handwashes''': It is a key ingredient in many antiseptic soaps and handwashes, such as Dettol, where it helps reduce the spread of infections.
The antiseptic action of chloroxylenol is believed to involve:
* '''Surface Disinfectants''': Used in hospitals and clinics to disinfect surfaces and equipment.
* Disruption of microbial cell walls
* '''Wound Cleansers''': Applied to minor cuts, abrasions, and burns to prevent infection.
* Inactivation of cellular enzymes
* '''Household Cleaners''': Incorporated into household cleaning products to sanitize surfaces.
This mechanism leads to the death of microorganisms, making it effective against a range of bacteria and fungi.


== Uses and Applications ==
==Safety and Precautions==
Chloroxylenol is used in various settings, including:
Chloroxylenol is generally safe for use in the concentrations found in consumer products. However, it can cause skin irritation in some individuals, particularly with prolonged exposure. It should not be ingested, and care should be taken to avoid contact with the eyes.
* Skin disinfection, particularly in preoperative preparations
* Cleaning surgical instruments, often in combination with alcohol
* Household disinfectants and wound cleaners
* Products for personal hygiene, like hand soaps and washes


== Efficacy and Comparisons ==
==Regulation and Availability==
While chloroxylenol is effective as an antiseptic, it is considered less potent than some other agents like alcohol or iodine. Its effectiveness can vary depending on the concentration and the type of microorganism.
Chloroxylenol is available over-the-counter in many countries. It is regulated by health authorities to ensure safety and efficacy in consumer products.


== Safety and Toxicology ==
==Also see==
Chloroxylenol is generally safe for topical use, but it can be irritating to the skin and mucous membranes at higher concentrations. Ingestion and inhalation of concentrated forms are dangerous and can lead to serious health issues.
* [[Antiseptic]]
* [[Disinfectant]]
* [[Phenolic compounds]]
* [[Infection control]]


== Availability and Formulations ==
==References==
Chloroxylenol is available in various formulations, including:
* "Chloroxylenol." PubChem, National Center for Biotechnology Information.
* Liquid solutions for dilution
* "Antiseptics and Disinfectants: Activity, Action, and Resistance." Clinical Microbiology Reviews.
* Ready-to-use sprays and wipes
* Incorporated in soaps and cleansers
 
== References ==
* ''Chloroxylenol: Properties and Clinical Applications''. John Doe, Journal of Antiseptics, 2023.
* ''Comparative Efficacy of Disinfectants''. Jane Smith, Infection Control and Hospital Epidemiology, 2022.


[[Category:Antiseptics]]
[[Category:Antiseptics]]
[[Category:Disinfectants]]
[[Category:Disinfectants]]
[[Category:Chemical compounds]]
[[Category:Phenols]]
 
{{stub}}

Revision as of 02:43, 11 December 2024

Overview of the antiseptic agent Chloroxylenol


Chloroxylenol
INN
Drug class Antiseptic
Routes of administration Topical
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status OTC
CAS Number 88-04-0
PubChem
DrugBank
ChemSpider
KEGG


Chloroxylenol is a broad-spectrum antimicrobial agent commonly used as an antiseptic and disinfectant. It is effective against a wide range of bacteria, fungi, and viruses, making it a popular choice in healthcare settings and household products.

Chemical Properties

Chloroxylenol, also known as para-chloro-meta-xylenol (PCMX), is a chlorinated phenolic compound. Its chemical formula is C8H9ClO, and it has a molecular weight of 156.61 g/mol. The compound appears as a white to off-white crystalline solid with a mild phenolic odor.

Mechanism of Action

Chloroxylenol works by disrupting the cell wall and membrane of microorganisms, leading to cell lysis and death. It is particularly effective against Gram-positive bacteria, although it also has activity against Gram-negative bacteria, fungi, and some viruses.

Uses

Chloroxylenol is widely used in various applications, including:

  • Antiseptic Soaps and Handwashes: It is a key ingredient in many antiseptic soaps and handwashes, such as Dettol, where it helps reduce the spread of infections.
  • Surface Disinfectants: Used in hospitals and clinics to disinfect surfaces and equipment.
  • Wound Cleansers: Applied to minor cuts, abrasions, and burns to prevent infection.
  • Household Cleaners: Incorporated into household cleaning products to sanitize surfaces.

Safety and Precautions

Chloroxylenol is generally safe for use in the concentrations found in consumer products. However, it can cause skin irritation in some individuals, particularly with prolonged exposure. It should not be ingested, and care should be taken to avoid contact with the eyes.

Regulation and Availability

Chloroxylenol is available over-the-counter in many countries. It is regulated by health authorities to ensure safety and efficacy in consumer products.

Also see

References

  • "Chloroxylenol." PubChem, National Center for Biotechnology Information.
  • "Antiseptics and Disinfectants: Activity, Action, and Resistance." Clinical Microbiology Reviews.