Hyzetimibe: Difference between revisions
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== Hyzetimibe == | {{Short description|A cholesterol absorption inhibitor}} | ||
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'''Hyzetimibe''' is a pharmaceutical compound used primarily to lower cholesterol levels in the blood. It functions as a cholesterol absorption inhibitor, which helps reduce the amount of cholesterol absorbed by the intestines. This medication is often prescribed to patients who have high cholesterol levels that cannot be controlled by diet and exercise alone. | |||
==Mechanism of Action== | |||
Hyzetimibe works by selectively inhibiting the absorption of cholesterol in the small intestine. It targets the [[Niemann-Pick C1-Like 1]] (NPC1L1) protein, which is responsible for the uptake of cholesterol into the enterocytes. By blocking this protein, Hyzetimibe reduces the amount of cholesterol that enters the bloodstream, thereby lowering total cholesterol levels, including [[low-density lipoprotein]] (LDL) cholesterol, which is often referred to as "bad" cholesterol. | |||
== | ==Clinical Use== | ||
Hyzetimibe | Hyzetimibe is typically used in conjunction with [[statins]], a class of drugs that reduce cholesterol production in the liver, to achieve a more significant reduction in cholesterol levels. It is particularly beneficial for patients who are unable to tolerate high doses of statins or who have a genetic predisposition to high cholesterol, such as those with [[familial hypercholesterolemia]]. | ||
== | ==Dosage and Administration== | ||
Hyzetimibe is | Hyzetimibe is usually administered orally in the form of a tablet. The standard dosage is 10 mg once daily, with or without food. It is important for patients to adhere to their prescribed dosage and to continue following a cholesterol-lowering diet while taking this medication. | ||
== | ==Side Effects== | ||
Hyzetimibe | Common side effects of Hyzetimibe include headache, diarrhea, and fatigue. Some patients may experience muscle pain or liver enzyme abnormalities, especially when Hyzetimibe is used in combination with statins. Patients are advised to report any unusual symptoms to their healthcare provider. | ||
== | ==Contraindications== | ||
Hyzetimibe is contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levels. It should be used with caution in patients with moderate to severe hepatic impairment. | |||
==Related Pages== | |||
* [[Cholesterol]] | |||
== Related Pages == | |||
* [[Cholesterol | |||
* [[Statin]] | * [[Statin]] | ||
* [[Familial hypercholesterolemia]] | |||
* [[Niemann-Pick C1-Like 1]] | * [[Niemann-Pick C1-Like 1]] | ||
[[Category:Cholesterol-lowering agents]] | [[Category:Cholesterol-lowering agents]] | ||
[[Category: | [[Category:Hypolipidemic agents]] | ||
Latest revision as of 01:32, 6 March 2025
A cholesterol absorption inhibitor
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Hyzetimibe is a pharmaceutical compound used primarily to lower cholesterol levels in the blood. It functions as a cholesterol absorption inhibitor, which helps reduce the amount of cholesterol absorbed by the intestines. This medication is often prescribed to patients who have high cholesterol levels that cannot be controlled by diet and exercise alone.
Mechanism of Action[edit]
Hyzetimibe works by selectively inhibiting the absorption of cholesterol in the small intestine. It targets the Niemann-Pick C1-Like 1 (NPC1L1) protein, which is responsible for the uptake of cholesterol into the enterocytes. By blocking this protein, Hyzetimibe reduces the amount of cholesterol that enters the bloodstream, thereby lowering total cholesterol levels, including low-density lipoprotein (LDL) cholesterol, which is often referred to as "bad" cholesterol.
Clinical Use[edit]
Hyzetimibe is typically used in conjunction with statins, a class of drugs that reduce cholesterol production in the liver, to achieve a more significant reduction in cholesterol levels. It is particularly beneficial for patients who are unable to tolerate high doses of statins or who have a genetic predisposition to high cholesterol, such as those with familial hypercholesterolemia.
Dosage and Administration[edit]
Hyzetimibe is usually administered orally in the form of a tablet. The standard dosage is 10 mg once daily, with or without food. It is important for patients to adhere to their prescribed dosage and to continue following a cholesterol-lowering diet while taking this medication.
Side Effects[edit]
Common side effects of Hyzetimibe include headache, diarrhea, and fatigue. Some patients may experience muscle pain or liver enzyme abnormalities, especially when Hyzetimibe is used in combination with statins. Patients are advised to report any unusual symptoms to their healthcare provider.
Contraindications[edit]
Hyzetimibe is contraindicated in patients with active liver disease or unexplained persistent elevations in hepatic transaminase levels. It should be used with caution in patients with moderate to severe hepatic impairment.
