Akuammidine: Difference between revisions

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{{Short description|An alkaloid found in the seeds of the Picralima nitida plant}}
 
{{Infobox chemical
{{Infobox drug
| name = Akuammidine
| name = Akuammidine
| image = Akuammidine_structure.png
| image = <!-- Image file name here, if available -->
| image_size = 200px
| width =
| image_alt = Structural formula of Akuammidine
| alt =
| pin =  
| caption =
| othernames =  
| pronounce =
| section1 =  
| tradename =
| casno = 483-29-2
| Drugs.com =
| pubchem = 442667
| MedlinePlus =  
| chemspiderid = 390837
| pregnancy_AU =  
| smiles = C1CN2C3=C(C=CC=C3)C4=C2C(=C1)C(=O)N(C4)C
| pregnancy_US =  
| inchi = 1S/C20H22N2O/c1-22-18-11-5-3-9-15(18)20-17(22)10-4-6-12(20)13-7-8-14(23)19(13)21-16(10)2/h3-9,16-17,21H,10-11H2,1-2H3
| pregnancy_category =  
| inchi_key = QXQZUNJZQZKJQF-UHFFFAOYSA-N
| legal_AU =  
| section2 =  
| legal_CA =  
| formula = C20H22N2O
| legal_UK =  
| molar_mass = 306.40 g/mol
| legal_US =  
| legal_status =  
| routes_of_administration =  
| bioavailability =  
| protein_bound =  
| metabolism =  
| elimination_half-life =  
| excretion =  
| CAS_number = 483-04-5
| ATC_prefix =
| ATC_suffix =
| PubChem = 442667
| IUPHAR_ligand =
| DrugBank =
| ChemSpiderID = 390946
| UNII = 0F8K3R7F6L
| KEGG =  
| ChEBI = 3214
| ChEMBL = 2104690
| synonyms =  
}}
}}


'''Akuammidine''' is an indole [[alkaloid]] found in the seeds of the [[Picralima nitida]] plant, which is native to tropical Africa. This compound is one of several alkaloids present in the seeds, which have been traditionally used for their medicinal properties.
'''Akuammidine''' is an [[indole alkaloid]] found in the seeds of the [[Picralima nitida]] plant, which is native to [[West Africa]]. It is one of several alkaloids present in the seeds, which have been traditionally used for their [[analgesic]] and [[antipyretic]] properties.


==Chemical Structure and Properties==
== Chemical Structure ==
Akuammidine is a monoterpene indole alkaloid with the molecular formula C20H22N2O. It is structurally related to other indole alkaloids such as [[yohimbine]] and [[strychnine]]. The compound features a complex polycyclic structure that includes an indole moiety, which is a common feature among many biologically active alkaloids.
Akuammidine is classified as an indole alkaloid, which is a type of [[alkaloid]] that contains a structural motif known as an indole. Indole alkaloids are known for their diverse range of biological activities.


==Pharmacology==
== Pharmacology ==
Akuammidine has been studied for its potential pharmacological effects, which include analgesic and anti-inflammatory properties. It is believed to interact with opioid receptors in the central nervous system, similar to other indole alkaloids. However, the exact mechanism of action and its efficacy in clinical settings remain subjects of ongoing research.
Akuammidine has been studied for its potential [[pharmacological]] effects, particularly its ability to act as an [[analgesic]]. It is believed to interact with [[opioid receptors]], which are part of the body's [[pain management]] system. However, more research is needed to fully understand its mechanism of action and potential therapeutic uses.


==Traditional Uses==
== Traditional Uses ==
The seeds of Picralima nitida, commonly known as akuamma seeds, have been used in traditional African medicine for the treatment of various ailments, including pain, fever, and gastrointestinal issues. The presence of akuammidine and other alkaloids is thought to contribute to these therapeutic effects.
In traditional [[African medicine]], the seeds of Picralima nitida, which contain akuammidine, are used to treat a variety of ailments, including [[fever]], [[pain]], and [[malaria]]. The seeds are often ground into a powder and consumed or used to make a medicinal tea.


==Research and Development==
== Research and Development ==
Current research on akuammidine is focused on understanding its pharmacological profile and potential therapeutic applications. Studies are being conducted to explore its efficacy as an analgesic and its potential use in treating opioid addiction and withdrawal symptoms.
Current research is focused on isolating and characterizing the active compounds in Picralima nitida seeds, including akuammidine, to better understand their potential health benefits and applications in modern medicine.


==Safety and Toxicity==
== See Also ==
While akuammidine has shown promise in preliminary studies, its safety profile is not fully understood. Further research is needed to determine its toxicity, potential side effects, and safe dosage ranges for human use.
 
==Also see==
* [[Indole alkaloid]]
* [[Indole alkaloid]]
* [[Picralima nitida]]
* [[Picralima nitida]]
* [[Opioid receptor]]
* [[Analgesic]]
* [[Traditional African medicine]]
 
== References ==
<references />


{{Alkaloids}}
== External Links ==
{{Pharmacology}}
* [PubChem Entry for Akuammidine](https://pubchem.ncbi.nlm.nih.gov/compound/442667)


[[Category:Alkaloids]]
[[Category:Alkaloids]]
[[Category:Indole alkaloids]]
[[Category:Analgesics]]
[[Category:Pharmacology]]
[[Category:Traditional African medicine]]

Latest revision as of 17:24, 27 December 2024


Akuammidine
[[File:|frameless|220px|alt=|]]
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number 483-04-5
PubChem 442667
DrugBank
ChemSpider 390946
KEGG


Akuammidine is an indole alkaloid found in the seeds of the Picralima nitida plant, which is native to West Africa. It is one of several alkaloids present in the seeds, which have been traditionally used for their analgesic and antipyretic properties.

Chemical Structure[edit]

Akuammidine is classified as an indole alkaloid, which is a type of alkaloid that contains a structural motif known as an indole. Indole alkaloids are known for their diverse range of biological activities.

Pharmacology[edit]

Akuammidine has been studied for its potential pharmacological effects, particularly its ability to act as an analgesic. It is believed to interact with opioid receptors, which are part of the body's pain management system. However, more research is needed to fully understand its mechanism of action and potential therapeutic uses.

Traditional Uses[edit]

In traditional African medicine, the seeds of Picralima nitida, which contain akuammidine, are used to treat a variety of ailments, including fever, pain, and malaria. The seeds are often ground into a powder and consumed or used to make a medicinal tea.

Research and Development[edit]

Current research is focused on isolating and characterizing the active compounds in Picralima nitida seeds, including akuammidine, to better understand their potential health benefits and applications in modern medicine.

See Also[edit]

References[edit]

<references />

External Links[edit]