Kyrle disease: Difference between revisions
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{{Infobox medical condition | |||
| name = Kyrle disease | |||
| synonyms = [[Hyperkeratosis follicularis et parafollicularis in cutem penetrans]] | |||
| specialty = [[Dermatology]] | |||
| symptoms = [[Hyperkeratotic]] papules, [[pruritus]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = Chronic | |||
| causes = Unknown, possibly associated with [[diabetes mellitus]], [[chronic renal failure]], and [[liver disease]] | |||
| risks = [[Diabetes]], [[renal failure]], [[liver dysfunction]] | |||
| diagnosis = [[Clinical diagnosis]], [[skin biopsy]] | |||
| differential = [[Prurigo nodularis]], [[lichen planus]], [[psoriasis]] | |||
| treatment = [[Keratolytics]], [[retinoids]], [[topical steroids]] | |||
| prognosis = Variable, often chronic | |||
| frequency = Rare | |||
}} | |||
'''Kyrle disease''' | '''Kyrle disease''' | ||
'''Kyrle disease''', also known as '''hyperkeratosis follicularis et parafollicularis in cutem penetrans''', is a rare [[skin disorder]] characterized by the development of large [[keratotic]] papules, primarily on the [[extremities]]. It was first described by the Austrian dermatologist [[Josef Kyrle]] in 1916. | '''Kyrle disease''', also known as '''hyperkeratosis follicularis et parafollicularis in cutem penetrans''', is a rare [[skin disorder]] characterized by the development of large [[keratotic]] papules, primarily on the [[extremities]]. It was first described by the Austrian dermatologist [[Josef Kyrle]] in 1916. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
Kyrle disease typically presents with [[hyperkeratotic]] papules that can range from 1 to 10 mm in diameter. These lesions are often found on the [[legs]], [[arms]], and [[trunk]], and they may be associated with [[pruritus]] (itching). The papules are usually [[skin-colored]] or [[brown]] and have a central keratin plug. | Kyrle disease typically presents with [[hyperkeratotic]] papules that can range from 1 to 10 mm in diameter. These lesions are often found on the [[legs]], [[arms]], and [[trunk]], and they may be associated with [[pruritus]] (itching). The papules are usually [[skin-colored]] or [[brown]] and have a central keratin plug. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The exact cause of Kyrle disease is not well understood. It is believed to be related to [[metabolic disorders]] such as [[diabetes mellitus]] and [[chronic renal failure]]. The disease is characterized by the abnormal proliferation of [[keratinocytes]] and the formation of keratin plugs that penetrate the [[epidermis]] and [[dermis]]. | The exact cause of Kyrle disease is not well understood. It is believed to be related to [[metabolic disorders]] such as [[diabetes mellitus]] and [[chronic renal failure]]. The disease is characterized by the abnormal proliferation of [[keratinocytes]] and the formation of keratin plugs that penetrate the [[epidermis]] and [[dermis]]. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of Kyrle disease is primarily clinical, based on the characteristic appearance of the lesions. A [[skin biopsy]] can be performed to confirm the diagnosis, revealing hyperkeratosis, parakeratosis, and the presence of keratin plugs. | The diagnosis of Kyrle disease is primarily clinical, based on the characteristic appearance of the lesions. A [[skin biopsy]] can be performed to confirm the diagnosis, revealing hyperkeratosis, parakeratosis, and the presence of keratin plugs. | ||
==Treatment== | ==Treatment== | ||
There is no definitive cure for Kyrle disease. Treatment is mainly symptomatic and may include the use of [[topical]] [[keratolytics]], such as [[salicylic acid]] and [[urea]], to reduce the hyperkeratosis. In some cases, [[systemic retinoids]] may be prescribed to help control the proliferation of keratinocytes. | There is no definitive cure for Kyrle disease. Treatment is mainly symptomatic and may include the use of [[topical]] [[keratolytics]], such as [[salicylic acid]] and [[urea]], to reduce the hyperkeratosis. In some cases, [[systemic retinoids]] may be prescribed to help control the proliferation of keratinocytes. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for Kyrle disease varies. While the condition is chronic and can be persistent, it is generally not life-threatening. The severity of symptoms can fluctuate, and some patients may experience periods of remission. | The prognosis for Kyrle disease varies. While the condition is chronic and can be persistent, it is generally not life-threatening. The severity of symptoms can fluctuate, and some patients may experience periods of remission. | ||
==Related Conditions== | ==Related Conditions== | ||
Kyrle disease is part of a group of disorders known as [[follicular keratoses]], which also includes conditions such as [[keratosis pilaris]] and [[lichen spinulosus]]. | Kyrle disease is part of a group of disorders known as [[follicular keratoses]], which also includes conditions such as [[keratosis pilaris]] and [[lichen spinulosus]]. | ||
==See Also== | ==See Also== | ||
* [[Keratosis pilaris]] | * [[Keratosis pilaris]] | ||
| Line 27: | Line 35: | ||
* [[Chronic renal failure]] | * [[Chronic renal failure]] | ||
* [[Hyperkeratosis]] | * [[Hyperkeratosis]] | ||
==References== | ==References== | ||
{{Reflist}} | {{Reflist}} | ||
==External Links== | ==External Links== | ||
{{Commons category|Kyrle disease}} | {{Commons category|Kyrle disease}} | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Skin conditions resulting from errors in metabolism]] | [[Category:Skin conditions resulting from errors in metabolism]] | ||
[[Category:Genodermatoses]] | [[Category:Genodermatoses]] | ||
{{Dermatology-stub}} | {{Dermatology-stub}} | ||
{{No image}} | |||
Latest revision as of 04:33, 4 April 2025
| Kyrle disease | |
|---|---|
| Synonyms | Hyperkeratosis follicularis et parafollicularis in cutem penetrans |
| Pronounce | N/A |
| Specialty | Dermatology |
| Symptoms | Hyperkeratotic papules, pruritus |
| Complications | N/A |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Unknown, possibly associated with diabetes mellitus, chronic renal failure, and liver disease |
| Risks | Diabetes, renal failure, liver dysfunction |
| Diagnosis | Clinical diagnosis, skin biopsy |
| Differential diagnosis | Prurigo nodularis, lichen planus, psoriasis |
| Prevention | N/A |
| Treatment | Keratolytics, retinoids, topical steroids |
| Medication | N/A |
| Prognosis | Variable, often chronic |
| Frequency | Rare |
| Deaths | N/A |
Kyrle disease
Kyrle disease, also known as hyperkeratosis follicularis et parafollicularis in cutem penetrans, is a rare skin disorder characterized by the development of large keratotic papules, primarily on the extremities. It was first described by the Austrian dermatologist Josef Kyrle in 1916.
Clinical Presentation[edit]
Kyrle disease typically presents with hyperkeratotic papules that can range from 1 to 10 mm in diameter. These lesions are often found on the legs, arms, and trunk, and they may be associated with pruritus (itching). The papules are usually skin-colored or brown and have a central keratin plug.
Pathophysiology[edit]
The exact cause of Kyrle disease is not well understood. It is believed to be related to metabolic disorders such as diabetes mellitus and chronic renal failure. The disease is characterized by the abnormal proliferation of keratinocytes and the formation of keratin plugs that penetrate the epidermis and dermis.
Diagnosis[edit]
The diagnosis of Kyrle disease is primarily clinical, based on the characteristic appearance of the lesions. A skin biopsy can be performed to confirm the diagnosis, revealing hyperkeratosis, parakeratosis, and the presence of keratin plugs.
Treatment[edit]
There is no definitive cure for Kyrle disease. Treatment is mainly symptomatic and may include the use of topical keratolytics, such as salicylic acid and urea, to reduce the hyperkeratosis. In some cases, systemic retinoids may be prescribed to help control the proliferation of keratinocytes.
Prognosis[edit]
The prognosis for Kyrle disease varies. While the condition is chronic and can be persistent, it is generally not life-threatening. The severity of symptoms can fluctuate, and some patients may experience periods of remission.
Related Conditions[edit]
Kyrle disease is part of a group of disorders known as follicular keratoses, which also includes conditions such as keratosis pilaris and lichen spinulosus.
See Also[edit]
References[edit]
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External Links[edit]
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