Mesoblastic nephroma: Difference between revisions
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[[File:Histopathology_of_congenital_mesoblastic_nephroma.jpg| | {{SI}} | ||
{{Infobox medical condition | |||
| name = Mesoblastic nephroma | |||
| image = [[File:Histopathology_of_congenital_mesoblastic_nephroma.jpg|250px]] | |||
| caption = Histopathology of congenital mesoblastic nephroma | |||
| field = [[Oncology]], [[Nephrology]] | |||
| synonyms = Congenital mesoblastic nephroma | |||
| symptoms = [[Abdominal mass]], [[Hematuria]], [[Hypertension]] | |||
| complications = [[Metastasis]] (rare) | |||
| onset = [[Infancy]] | |||
| duration = Variable | |||
| types = Classic, Cellular, Mixed | |||
| causes = Unknown | |||
| risks = [[Genetic predisposition]] | |||
| diagnosis = [[Ultrasound]], [[CT scan]], [[MRI]], [[Biopsy]] | |||
| differential = [[Wilms' tumor]], [[Neuroblastoma]], [[Renal cell carcinoma]] | |||
| treatment = [[Surgery]], [[Chemotherapy]] | |||
| medication = [[Vincristine]], [[Dactinomycin]] | |||
| prognosis = Generally good with treatment | |||
| frequency = Rare | |||
| deaths = Rare | |||
}} | |||
'''Mesoblastic nephroma''' is a rare [[renal tumor]] that primarily affects [[infant]]s and [[newborn]]s. It is also known as congenital mesoblastic nephroma (CMN) and is the most common renal tumor in this age group. | |||
==Classification== | ==Classification== | ||
Mesoblastic nephroma is classified into two main types: | Mesoblastic nephroma is classified into two main types: | ||
* '''Classic mesoblastic nephroma''': This type is characterized by spindle-shaped cells and resembles [[fibromatosis]]. | * '''Classic mesoblastic nephroma''': This type is characterized by spindle-shaped cells and resembles [[fibromatosis]]. | ||
* '''Cellular mesoblastic nephroma''': This type is more aggressive and has a higher potential for recurrence. It is characterized by densely packed cells and can resemble [[Wilms' tumor]]. | * '''Cellular mesoblastic nephroma''': This type is more aggressive and has a higher potential for recurrence. It is characterized by densely packed cells and can resemble [[Wilms' tumor]]. | ||
==Epidemiology== | ==Epidemiology== | ||
Mesoblastic nephroma is most commonly diagnosed in the first three months of life. It accounts for approximately 3-10% of all [[pediatric]] renal tumors. There is no significant gender predilection. | Mesoblastic nephroma is most commonly diagnosed in the first three months of life. It accounts for approximately 3-10% of all [[pediatric]] renal tumors. There is no significant gender predilection. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The exact cause of mesoblastic nephroma is not well understood. It is believed to arise from abnormal development of the [[metanephric blastema]], which is the embryonic precursor to the [[kidney]]. | The exact cause of mesoblastic nephroma is not well understood. It is believed to arise from abnormal development of the [[metanephric blastema]], which is the embryonic precursor to the [[kidney]]. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
Infants with mesoblastic nephroma typically present with an abdominal mass that is often discovered incidentally. Other symptoms may include [[hematuria]], [[hypertension]], and [[polyhydramnios]] in the prenatal period. | Infants with mesoblastic nephroma typically present with an abdominal mass that is often discovered incidentally. Other symptoms may include [[hematuria]], [[hypertension]], and [[polyhydramnios]] in the prenatal period. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of mesoblastic nephroma is usually made through a combination of imaging studies and histopathological examination. [[Ultrasound]] is often the first imaging modality used, followed by [[CT scan]] or [[MRI]] for further evaluation. A definitive diagnosis is made through a biopsy or surgical resection of the tumor. | The diagnosis of mesoblastic nephroma is usually made through a combination of imaging studies and histopathological examination. [[Ultrasound]] is often the first imaging modality used, followed by [[CT scan]] or [[MRI]] for further evaluation. A definitive diagnosis is made through a biopsy or surgical resection of the tumor. | ||
==Treatment== | ==Treatment== | ||
The primary treatment for mesoblastic nephroma is surgical resection. The prognosis is generally excellent for the classic type, with a high cure rate following complete removal of the tumor. The cellular type may require additional treatment, such as [[chemotherapy]], due to its higher risk of recurrence. | The primary treatment for mesoblastic nephroma is surgical resection. The prognosis is generally excellent for the classic type, with a high cure rate following complete removal of the tumor. The cellular type may require additional treatment, such as [[chemotherapy]], due to its higher risk of recurrence. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for infants with mesoblastic nephroma is generally favorable, especially for the classic type. The cellular type has a higher risk of recurrence and may require closer follow-up and additional treatment. | The prognosis for infants with mesoblastic nephroma is generally favorable, especially for the classic type. The cellular type has a higher risk of recurrence and may require closer follow-up and additional treatment. | ||
==See also== | ==See also== | ||
* [[Wilms' tumor]] | * [[Wilms' tumor]] | ||
* [[Renal cell carcinoma]] | * [[Renal cell carcinoma]] | ||
* [[Pediatric oncology]] | * [[Pediatric oncology]] | ||
==References== | ==References== | ||
{{Reflist}} | {{Reflist}} | ||
==External links== | ==External links== | ||
{{Commons category|Mesoblastic nephroma}} | {{Commons category|Mesoblastic nephroma}} | ||
[[Category:Nephrology]] | [[Category:Nephrology]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
| Line 40: | Line 51: | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
{{medicine-stub}} | {{medicine-stub}} | ||
Latest revision as of 04:00, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Mesoblastic nephroma | |
|---|---|
| |
| Synonyms | Congenital mesoblastic nephroma |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Abdominal mass, Hematuria, Hypertension |
| Complications | Metastasis (rare) |
| Onset | Infancy |
| Duration | Variable |
| Types | Classic, Cellular, Mixed |
| Causes | Unknown |
| Risks | Genetic predisposition |
| Diagnosis | Ultrasound, CT scan, MRI, Biopsy |
| Differential diagnosis | Wilms' tumor, Neuroblastoma, Renal cell carcinoma |
| Prevention | N/A |
| Treatment | Surgery, Chemotherapy |
| Medication | Vincristine, Dactinomycin |
| Prognosis | Generally good with treatment |
| Frequency | Rare |
| Deaths | Rare |
Mesoblastic nephroma is a rare renal tumor that primarily affects infants and newborns. It is also known as congenital mesoblastic nephroma (CMN) and is the most common renal tumor in this age group.
Classification[edit]
Mesoblastic nephroma is classified into two main types:
- Classic mesoblastic nephroma: This type is characterized by spindle-shaped cells and resembles fibromatosis.
- Cellular mesoblastic nephroma: This type is more aggressive and has a higher potential for recurrence. It is characterized by densely packed cells and can resemble Wilms' tumor.
Epidemiology[edit]
Mesoblastic nephroma is most commonly diagnosed in the first three months of life. It accounts for approximately 3-10% of all pediatric renal tumors. There is no significant gender predilection.
Pathophysiology[edit]
The exact cause of mesoblastic nephroma is not well understood. It is believed to arise from abnormal development of the metanephric blastema, which is the embryonic precursor to the kidney.
Clinical Presentation[edit]
Infants with mesoblastic nephroma typically present with an abdominal mass that is often discovered incidentally. Other symptoms may include hematuria, hypertension, and polyhydramnios in the prenatal period.
Diagnosis[edit]
The diagnosis of mesoblastic nephroma is usually made through a combination of imaging studies and histopathological examination. Ultrasound is often the first imaging modality used, followed by CT scan or MRI for further evaluation. A definitive diagnosis is made through a biopsy or surgical resection of the tumor.
Treatment[edit]
The primary treatment for mesoblastic nephroma is surgical resection. The prognosis is generally excellent for the classic type, with a high cure rate following complete removal of the tumor. The cellular type may require additional treatment, such as chemotherapy, due to its higher risk of recurrence.
Prognosis[edit]
The prognosis for infants with mesoblastic nephroma is generally favorable, especially for the classic type. The cellular type has a higher risk of recurrence and may require closer follow-up and additional treatment.
See also[edit]
References[edit]
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External links[edit]
