Indolent lymphoma: Difference between revisions
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[[File:Cutaneous_T-cell_lymphoma_-_very_high_mag.jpg|Cutaneous T-cell lymphoma - very high mag|thumb]] '''Indolent lymphoma''' refers to a group of [[lymphoma]]s, which are types of [[cancer]] that originate from the [[lymphocytes]] (a type of white blood cell) in the [[immune system]]. These lymphomas are characterized by their slow-growing nature, often presenting with few symptoms in the early stages. Indolent lymphomas are a subset of [[non-Hodgkin lymphomas (NHL)]] and contrast with the more aggressive forms of lymphoma, which require immediate treatment. | {{SI}} | ||
{{Infobox medical condition | |||
| name = Indolent lymphoma | |||
| image = [[File:Marrow_Follicullar_lymphoma.jpg|left|thumb|Micrograph of follicular lymphoma, a type of indolent lymphoma]] | |||
| caption = Micrograph of follicular lymphoma, a type of indolent lymphoma | |||
| field = [[Hematology]] | |||
| symptoms = [[Lymphadenopathy]], [[fatigue]], [[fever]], [[night sweats]], [[weight loss]] | |||
| complications = Transformation to [[aggressive lymphoma]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = [[Chronic (medicine)|Chronic]] | |||
| types = [[Follicular lymphoma]], [[Marginal zone lymphoma]], [[Small lymphocytic lymphoma]] | |||
| causes = [[Genetic mutations]], [[immune system]] dysfunction | |||
| risks = [[Age]], [[family history]], [[immunosuppression]] | |||
| diagnosis = [[Biopsy]], [[immunophenotyping]], [[imaging studies]] | |||
| treatment = [[Watchful waiting]], [[chemotherapy]], [[radiation therapy]], [[immunotherapy]] | |||
| prognosis = Variable, often long-term survival | |||
| frequency = Common among [[non-Hodgkin lymphoma]]s | |||
}} | |||
[[File:Cutaneous_T-cell_lymphoma_-_very_high_mag.jpg|Cutaneous T-cell lymphoma - very high mag|left|thumb]] '''Indolent lymphoma''' refers to a group of [[lymphoma]]s, which are types of [[cancer]] that originate from the [[lymphocytes]] (a type of white blood cell) in the [[immune system]]. These lymphomas are characterized by their slow-growing nature, often presenting with few symptoms in the early stages. Indolent lymphomas are a subset of [[non-Hodgkin lymphomas (NHL)]] and contrast with the more aggressive forms of lymphoma, which require immediate treatment. | |||
==Types of Indolent Lymphoma== | ==Types of Indolent Lymphoma== | ||
Several types of lymphoma fall under the category of indolent lymphoma, including but not limited to: | Several types of lymphoma fall under the category of indolent lymphoma, including but not limited to: | ||
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* [[Small lymphocytic lymphoma (SLL)]]: Closely related to [[chronic lymphocytic leukemia (CLL)]], SLL affects the B lymphocytes but is primarily found in the lymph nodes. | * [[Small lymphocytic lymphoma (SLL)]]: Closely related to [[chronic lymphocytic leukemia (CLL)]], SLL affects the B lymphocytes but is primarily found in the lymph nodes. | ||
* [[Lymphoplasmacytic lymphoma]]: A rare type of lymphoma that produces an excessive amount of a protein called monoclonal immunoglobulin M (IgM), leading to the condition known as Waldenström's macroglobulinemia. | * [[Lymphoplasmacytic lymphoma]]: A rare type of lymphoma that produces an excessive amount of a protein called monoclonal immunoglobulin M (IgM), leading to the condition known as Waldenström's macroglobulinemia. | ||
==Symptoms== | ==Symptoms== | ||
The symptoms of indolent lymphoma are often subtle and can include: | The symptoms of indolent lymphoma are often subtle and can include: | ||
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* Night sweats | * Night sweats | ||
* Unexplained weight loss | * Unexplained weight loss | ||
==Diagnosis== | ==Diagnosis== | ||
Diagnosis of indolent lymphoma typically involves a combination of: | Diagnosis of indolent lymphoma typically involves a combination of: | ||
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* Imaging tests, such as [[Computed tomography (CT) scan]] or [[Positron emission tomography (PET) scan]] | * Imaging tests, such as [[Computed tomography (CT) scan]] or [[Positron emission tomography (PET) scan]] | ||
* Biopsy of the affected lymph node | * Biopsy of the affected lymph node | ||
==Treatment== | ==Treatment== | ||
Treatment for indolent lymphoma varies depending on the stage and symptoms of the disease. In some cases, immediate treatment may not be necessary, and a watchful waiting approach is adopted. When treatment is required, options may include: | Treatment for indolent lymphoma varies depending on the stage and symptoms of the disease. In some cases, immediate treatment may not be necessary, and a watchful waiting approach is adopted. When treatment is required, options may include: | ||
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* [[Immunotherapy]] | * [[Immunotherapy]] | ||
* Targeted therapy drugs | * Targeted therapy drugs | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for indolent lymphoma patients can vary widely. Many individuals live with the disease for many years due to its slow-growing nature. Treatment advancements have significantly improved the outlook for many patients, although the disease is generally considered incurable with current therapies. | The prognosis for indolent lymphoma patients can vary widely. Many individuals live with the disease for many years due to its slow-growing nature. Treatment advancements have significantly improved the outlook for many patients, although the disease is generally considered incurable with current therapies. | ||
==See Also== | ==See Also== | ||
* [[Lymphoma]] | * [[Lymphoma]] | ||
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* [[Hodgkin lymphoma]] | * [[Hodgkin lymphoma]] | ||
* [[Cancer]] | * [[Cancer]] | ||
[[Category:Non-Hodgkin lymphoma]] | [[Category:Non-Hodgkin lymphoma]] | ||
[[Category:Cancer]] | [[Category:Cancer]] | ||
{{medicine-stub}} | {{medicine-stub}} | ||
Latest revision as of 00:49, 8 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Indolent lymphoma | |
|---|---|
 | |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Lymphadenopathy, fatigue, fever, night sweats, weight loss |
| Complications | Transformation to aggressive lymphoma |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | Follicular lymphoma, Marginal zone lymphoma, Small lymphocytic lymphoma |
| Causes | Genetic mutations, immune system dysfunction |
| Risks | Age, family history, immunosuppression |
| Diagnosis | Biopsy, immunophenotyping, imaging studies |
| Differential diagnosis | N/A |
| Prevention | N/A |
| Treatment | Watchful waiting, chemotherapy, radiation therapy, immunotherapy |
| Medication | N/A |
| Prognosis | Variable, often long-term survival |
| Frequency | Common among non-Hodgkin lymphomas |
| Deaths | N/A |
Indolent lymphoma refers to a group of lymphomas, which are types of cancer that originate from the lymphocytes (a type of white blood cell) in the immune system. These lymphomas are characterized by their slow-growing nature, often presenting with few symptoms in the early stages. Indolent lymphomas are a subset of non-Hodgkin lymphomas (NHL) and contrast with the more aggressive forms of lymphoma, which require immediate treatment.
Types of Indolent Lymphoma[edit]
Several types of lymphoma fall under the category of indolent lymphoma, including but not limited to:
- Follicular lymphoma: The most common type of indolent lymphoma, originating from B lymphocytes.
- Marginal zone lymphoma: Includes extranodal marginal zone B-cell lymphoma (also known as MALT lymphoma), nodal marginal zone lymphoma, and splenic marginal zone lymphoma.
- Small lymphocytic lymphoma (SLL): Closely related to chronic lymphocytic leukemia (CLL), SLL affects the B lymphocytes but is primarily found in the lymph nodes.
- Lymphoplasmacytic lymphoma: A rare type of lymphoma that produces an excessive amount of a protein called monoclonal immunoglobulin M (IgM), leading to the condition known as Waldenström's macroglobulinemia.
Symptoms[edit]
The symptoms of indolent lymphoma are often subtle and can include:
- Swollen, painless lymph nodes in the neck, armpits, or groin
- Fatigue
- Fever
- Night sweats
- Unexplained weight loss
Diagnosis[edit]
Diagnosis of indolent lymphoma typically involves a combination of:
- Physical examination
- Blood tests
- Imaging tests, such as Computed tomography (CT) scan or Positron emission tomography (PET) scan
- Biopsy of the affected lymph node
Treatment[edit]
Treatment for indolent lymphoma varies depending on the stage and symptoms of the disease. In some cases, immediate treatment may not be necessary, and a watchful waiting approach is adopted. When treatment is required, options may include:
- Chemotherapy
- Radiation therapy
- Immunotherapy
- Targeted therapy drugs
Prognosis[edit]
The prognosis for indolent lymphoma patients can vary widely. Many individuals live with the disease for many years due to its slow-growing nature. Treatment advancements have significantly improved the outlook for many patients, although the disease is generally considered incurable with current therapies.
See Also[edit]
