Levonantradol: Difference between revisions

Latest revision as of 01:14, 20 February 2025

Synthetic cannabinoid used for its antiemetic and analgesic properties

Levonantradol is a synthetic cannabinoid that has been studied for its potential use in treating nausea and pain. It is a derivative of dronabinol, which is the active component of tetrahydrocannabinol (THC), the primary psychoactive constituent of cannabis. Levonantradol is not currently approved for medical use but has been the subject of research due to its pharmacological properties.

Pharmacology[edit]

Levonantradol acts as an agonist at the cannabinoid receptors in the body, primarily the CB1 and CB2 receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain perception, appetite, and immune response.

Mechanism of Action[edit]

Levonantradol binds to cannabinoid receptors, mimicking the effects of naturally occurring cannabinoids. This binding leads to the modulation of neurotransmitter release, resulting in its analgesic and antiemetic effects. The activation of CB1 receptors in the central nervous system is primarily responsible for its ability to reduce pain and nausea.

Clinical Uses[edit]

Although not approved for clinical use, levonantradol has been investigated in clinical trials for its potential to treat:

Nausea and vomiting: Particularly in patients undergoing chemotherapy for cancer.
Pain management: Including neuropathic pain and pain associated with multiple sclerosis.

Side Effects[edit]

The side effects of levonantradol are similar to those of other cannabinoids and may include:

Research[edit]

Research on levonantradol has primarily focused on its potential as an antiemetic and analgesic. Studies have shown that it can be effective in reducing nausea and pain, but its psychoactive effects and potential for abuse have limited its development as a therapeutic agent.

Legal Status[edit]

Levonantradol is not approved for medical use in any country and is classified as a Schedule I controlled substance in the United States, indicating a high potential for abuse and no accepted medical use.

Related pages[edit]

Levonantradol[edit]

Levonantradol
Nantradol synthesis
Nantradols structure

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-'''Levonantradol''' is a synthetic cannabinoid derivative developed in the late 20th century. It is structurally related to both [[tetrahydrocannabinol]] (THC), the primary psychoactive compound found in [[Cannabis (plant)|cannabis]], and to [[nabilone]], another synthetic cannabinoid used for similar therapeutic purposes. Levonantradol has been researched primarily for its analgesic properties, particularly in the treatment of pain associated with cancer and chemotherapy.
+{{Short description|Synthetic cannabinoid used for its antiemetic and analgesic properties}}
-== Pharmacology ==
+'''Levonantradol''' is a synthetic [[cannabinoid]] that has been studied for its potential use in treating [[nausea]] and [[pain]]. It is a derivative of [[dronabinol]], which is the active component of [[tetrahydrocannabinol]] (THC), the primary psychoactive constituent of [[cannabis]]. Levonantradol is not currently approved for medical use but has been the subject of research due to its pharmacological properties.
-Levonantradol acts as an agonist at the CB1 and CB2 cannabinoid receptors, similar to other cannabinoids. The CB1 receptors are predominantly found in the central nervous system, affecting neurotransmission, while CB2 receptors are involved in the regulation of immune response. By activating these receptors, levonantradol can modulate pain perception and inflammation, making it a potential therapeutic agent for managing chronic pain and other conditions.
-== Clinical Use ==
+==Pharmacology==
-Initially, research into levonantradol focused on its effectiveness in managing pain associated with cancer and its treatments. Clinical trials in the 1980s suggested that it could be beneficial in reducing chemotherapy-induced nausea and vomiting, a common side effect experienced by cancer patients. However, despite its potential, levonantradol has not been widely adopted in clinical practice. This is partly due to the development and approval of other cannabinoids like [[dronabinol]] and nabilone, which have become more commonly used for these indications.
+Levonantradol acts as an agonist at the [[cannabinoid receptor|cannabinoid receptors]] in the body, primarily the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] receptors. These receptors are part of the [[endocannabinoid system]], which plays a role in regulating various physiological processes including [[pain perception]], [[appetite]], and [[immune response]].
-== Side Effects ==
+===Mechanism of Action===
-As with other cannabinoids, levonantradol can cause a range of side effects. These may include dizziness, dry mouth, euphoria, dysphoria, and somnolence. The psychoactive effects associated with CB1 receptor activation, such as euphoria and changes in perception, can limit its use in some patients. The severity and incidence of these side effects vary among individuals, influenced by factors such as dose, route of administration, and individual sensitivity to cannabinoids.
+Levonantradol binds to cannabinoid receptors, mimicking the effects of naturally occurring cannabinoids. This binding leads to the modulation of neurotransmitter release, resulting in its analgesic and antiemetic effects. The activation of CB1 receptors in the central nervous system is primarily responsible for its ability to reduce pain and nausea.
-== Legal Status ==
+==Clinical Uses==
-The legal status of levonantradol varies by country, largely due to its association with cannabis and synthetic cannabinoids. In many jurisdictions, it is classified as a controlled substance, which restricts its use, research, and production. The regulatory environment surrounding cannabinoids is complex and rapidly evolving, with ongoing debates about the medical use of cannabis and related compounds.
+Although not approved for clinical use, levonantradol has been investigated in clinical trials for its potential to treat:
-== Research and Development ==
+* '''[[Nausea and vomiting]]''': Particularly in patients undergoing [[chemotherapy]] for [[cancer]].
-Despite the challenges, research into levonantradol and other cannabinoids continues, driven by the need for effective pain management solutions and the therapeutic potential of the endocannabinoid system. Advances in our understanding of cannabinoid pharmacology and the development of novel delivery systems may pave the way for new applications of levonantradol in the future.
+* '''[[Pain management]]''': Including [[neuropathic pain]] and pain associated with [[multiple sclerosis]].
-== Conclusion ==
+==Side Effects==
-Levonantradol represents an interesting chapter in the ongoing exploration of cannabinoids for therapeutic use. While it has not achieved widespread clinical use, its development and study have contributed to the broader understanding of cannabinoid pharmacology and the potential medical applications of these compounds. As research progresses, there may yet be new roles for levonantradol in the management of pain and other conditions.
+The side effects of levonantradol are similar to those of other cannabinoids and may include:
+* [[Drowsiness]]
+* [[Dizziness]]
+* [[Dry mouth]]
+* [[Euphoria]]
+* [[Tachycardia]]
+==Research==
+Research on levonantradol has primarily focused on its potential as an antiemetic and analgesic. Studies have shown that it can be effective in reducing nausea and pain, but its psychoactive effects and potential for abuse have limited its development as a therapeutic agent.
+==Legal Status==
+Levonantradol is not approved for medical use in any country and is classified as a [[Schedule I controlled substance]] in the United States, indicating a high potential for abuse and no accepted medical use.
+==Related pages==
+* [[Cannabinoid receptor]]
+* [[Endocannabinoid system]]
+* [[Dronabinol]]
+* [[Tetrahydrocannabinol]]
 [[Category:Cannabinoids]]
 [[Category:Analgesics]]
-[[Category:Synthetic cannabinoids]]
+[[Category:Antiemetics]]
+== Levonantradol ==
-{{medicine-stub}}
+<gallery>
+File:Levonantradol.svg|Levonantradol
+File:Nantradol synthesis.svg|Nantradol synthesis
+File:Nantradols structure.png|Nantradols structure
+</gallery>