Muscarinic acetylcholine receptor M1: Difference between revisions

Latest revision as of 16:57, 29 December 2024

Overview of the Muscarinic acetylcholine receptor M1

The Muscarinic acetylcholine receptor M1 (CHRM1) is a G protein-coupled receptor that is encoded by the CHRM1 gene in humans. It is one of the five subtypes of muscarinic receptors, which are part of the acetylcholine receptor family. These receptors play a crucial role in the parasympathetic nervous system, mediating various physiological functions.

Function[edit]

The M1 receptor is primarily found in the central nervous system, particularly in the cerebral cortex, hippocampus, and striatum. It is involved in modulating cognitive functions such as learning and memory. Activation of the M1 receptor leads to the stimulation of phospholipase C, resulting in the production of inositol trisphosphate and diacylglycerol, which in turn increase intracellular calcium levels.

Clinical Significance[edit]

The M1 receptor has been implicated in several neurological disorders, including Alzheimer's disease and schizophrenia. It is a target for drug development aimed at improving cognitive deficits associated with these conditions. Agonists of the M1 receptor are being investigated for their potential therapeutic effects in enhancing cognitive function and neuroprotection.

Pharmacology[edit]

M1 receptor agonists and antagonists are used in research to study the receptor's role in various physiological and pathological processes. Pirenzepine is a selective M1 antagonist that has been used to differentiate between M1 and other muscarinic receptor subtypes. The development of selective M1 receptor modulators continues to be an area of active research.

References[edit]

External links[edit]

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-'''Muscarinic acetylcholine receptor M1''' (also known as '''M1 receptor''') is a type of [[muscarinic receptor]], one of the many types of [[receptor (biochemistry)|receptors]] in the [[human body]]. It is encoded by the human gene CHRM1.
-== Function ==
+{{Short description|Overview of the Muscarinic acetylcholine receptor M1}}
-The M1 receptor is found predominantly in the [[central nervous system]] and in peripheral tissues as well. It is predominantly found in the [[cerebral cortex]], [[hippocampus]], and [[striatum]]. It is involved in higher cognitive functions such as learning and memory.
+{{Infobox protein
+| name = Muscarinic acetylcholine receptor M1
+| image = <!-- Image removed -->
+| caption = <!-- Caption removed -->
+| symbol = CHRM1
+| hgncid = 1950
+| chromosomal_location = 11q12
+}}
-The M1 receptors are known to be involved in the regulation of [[gastric acid]] secretion, smooth muscle contraction, and [[thermoregulation]]. They also play a role in mediating the effects of [[acetylcholine]] in the central nervous system.
+The '''Muscarinic acetylcholine receptor M1''' ('''CHRM1''') is a [[G protein-coupled receptor]] that is encoded by the [[CHRM1 gene]] in humans. It is one of the five subtypes of [[muscarinic receptors]], which are part of the [[acetylcholine receptor]] family. These receptors play a crucial role in the [[parasympathetic nervous system]], mediating various physiological functions.
-== Structure ==
+== Function ==
-The M1 receptor is a [[G protein-coupled receptor]] that is coupled to Gq/11 type of G proteins. Activation of the receptor leads to activation of [[phospholipase C]] and production of [[inositol trisphosphate]] and [[diacylglycerol]], which in turn leads to an increase in intracellular [[calcium]] levels.
+The M1 receptor is primarily found in the [[central nervous system]], particularly in the [[cerebral cortex]], [[hippocampus]], and [[striatum]]. It is involved in modulating [[cognitive functions]] such as [[learning]] and [[memory]]. Activation of the M1 receptor leads to the stimulation of [[phospholipase C]], resulting in the production of [[inositol trisphosphate]] and [[diacylglycerol]], which in turn increase intracellular [[calcium]] levels.
-== Clinical significance ==
+== Clinical Significance ==
-Alterations in the function of the M1 receptor have been implicated in several neurological and psychiatric disorders including [[Alzheimer's disease]], [[schizophrenia]], and [[Parkinson's disease]].
+The M1 receptor has been implicated in several [[neurological disorders]], including [[Alzheimer's disease]] and [[schizophrenia]]. It is a target for drug development aimed at improving cognitive deficits associated with these conditions. [[Agonists]] of the M1 receptor are being investigated for their potential therapeutic effects in enhancing [[cognitive function]] and [[neuroprotection]].
-[[File:Muscarinic acetylcholine receptor M1.png|thumb|right|Muscarinic acetylcholine receptor M1]]
+== Pharmacology ==
+M1 receptor agonists and antagonists are used in research to study the receptor's role in various physiological and pathological processes. [[Pirenzepine]] is a selective M1 antagonist that has been used to differentiate between M1 and other muscarinic receptor subtypes. The development of selective M1 receptor modulators continues to be an area of active research.
 == See also ==
 * [[Muscarinic acetylcholine receptor]]
+* [[G protein-coupled receptor]]
 * [[Acetylcholine]]
-* [[G protein-coupled receptor]]
+* [[Neurotransmitter]]
 == References ==
 <references />
+== External links ==
+* {{MeSH|D018085}}
+* [https://www.wikimd.com/wiki/Muscarinic_acetylcholine_receptor_M1 Muscarinic acetylcholine receptor M1 on WikiMD]
+[[Category:Muscarinic acetylcholine receptors]]
 [[Category:G protein-coupled receptors]]
 [[Category:Neurotransmitter receptors]]
-[[Category:Acetylcholine]]
+[[Category:Human proteins]]
-{{G protein-coupled receptors}}
-{{medicine-stub}}