Trestolone acetate: Difference between revisions

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'''Trestolone acetate''' (also known as '''7α-methyl-19-nortestosterone''' (MENT), '''MENT Acetate''' or '''MENT Act''') is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is a potent agonist of the androgen receptor (AR) and hence is a powerful androgen and anabolic.
== Trestolone Acetate ==


==Chemistry==
[[File:Trestolone_acetate.svg|thumb|right|Chemical structure of Trestolone Acetate]]
Trestolone acetate, as mentioned, is a synthetic derivative of [[nandrolone]]. It is characterized by a modification at the 7th position with a methyl group which increases its androgenic potency. The acetate ester in trestolone acetate increases its solubility in oil, which allows the drug to have a longer half-life and to be provided in an injectable form.


==Pharmacology==
'''Trestolone acetate''', also known as 7_-methyl-19-nortestosterone 17_-acetate (MENT acetate), is a synthetic [[androgen]] and [[anabolic steroid]] (AAS) that is used in scientific research. It is a potent [[androgen receptor]] agonist and is known for its strong anabolic effects.
As an [[AAS]], trestolone acetate is an agonist of the [[androgen receptor]], the biological target of androgens like testosterone and dihydrotestosterone. It has strong androgenic effects and moderate anabolic effects, which make it useful for producing masculinization and suitable for androgen replacement therapy. Trestolone acetate is a potent agonist of the androgen receptor and hence is a powerful androgen.


==Medical uses==
== Chemical Properties ==
Trestolone acetate is currently being researched for its potential uses in male contraception and testosterone replacement therapy. Due to its potent androgenic effects, it can effectively suppress the production of gonadotropins and prevent the testes from producing sperm, making it a potential candidate for male contraception. In testosterone replacement therapy, it can be used to restore normal levels of testosterone in those with low testosterone levels.


==Side effects==
Trestolone acetate is a derivative of [[nandrolone]], with a methyl group added at the 7_ position. This modification increases its [[androgenic]] and [[anabolic]] potency compared to nandrolone. The acetate ester attached to the 17_-hydroxyl group prolongs its duration of action by slowing its release into the bloodstream.
Like other AAS, trestolone acetate has potential side effects, most notably its virilizing effects such as acne, increased body and facial hair growth, and deepening of the voice. It can also have adverse effects on cholesterol levels, liver function, and cardiovascular health.  


==See also==
== Mechanism of Action ==
 
As an androgen receptor agonist, trestolone acetate binds to the androgen receptor with high affinity. This binding initiates a cascade of events that lead to increased protein synthesis and muscle growth. It also has effects on the [[hypothalamic-pituitary-gonadal axis]], suppressing the production of endogenous [[testosterone]] and [[spermatogenesis]].
 
== Uses in Research ==
 
Trestolone acetate is primarily used in research settings to study its effects on muscle growth, [[bone density]], and its potential as a male [[contraceptive]]. Its potent anabolic effects make it a subject of interest for understanding muscle wasting conditions and other disorders related to androgen deficiency.
 
== Potential Applications ==
 
Research into trestolone acetate has explored its use as a male contraceptive due to its ability to suppress [[spermatogenesis]] while maintaining androgenic effects. It is also being studied for its potential in treating conditions such as [[hypogonadism]] and [[muscle wasting]] diseases.
 
== Side Effects ==
 
Like other anabolic steroids, trestolone acetate can cause a range of side effects. These may include [[acne]], [[gynecomastia]], [[hypertension]], and alterations in [[lipid profile]]. Long-term use can lead to [[liver damage]] and [[cardiovascular disease]].
 
== Related Pages ==
 
* [[Androgen receptor]]
* [[Anabolic steroid]]
* [[Anabolic steroid]]
* [[Androgen replacement therapy]]
* [[Nandrolone]]
* [[Male contraception]]
* [[Testosterone]]
 
* [[Hypogonadism]]
==References==
<references />


[[Category:Anabolic steroids]]
[[Category:Androgens and anabolic steroids]]
[[Category:Androgens]]
[[Category:Hormonal contraception]]
[[Category:Male contraception]]
[[Category:Testosterone]]
{{Anabolic steroid-stub}}
{{Pharma-stub}}

Latest revision as of 11:11, 15 February 2025

Trestolone Acetate[edit]

Chemical structure of Trestolone Acetate

Trestolone acetate, also known as 7_-methyl-19-nortestosterone 17_-acetate (MENT acetate), is a synthetic androgen and anabolic steroid (AAS) that is used in scientific research. It is a potent androgen receptor agonist and is known for its strong anabolic effects.

Chemical Properties[edit]

Trestolone acetate is a derivative of nandrolone, with a methyl group added at the 7_ position. This modification increases its androgenic and anabolic potency compared to nandrolone. The acetate ester attached to the 17_-hydroxyl group prolongs its duration of action by slowing its release into the bloodstream.

Mechanism of Action[edit]

As an androgen receptor agonist, trestolone acetate binds to the androgen receptor with high affinity. This binding initiates a cascade of events that lead to increased protein synthesis and muscle growth. It also has effects on the hypothalamic-pituitary-gonadal axis, suppressing the production of endogenous testosterone and spermatogenesis.

Uses in Research[edit]

Trestolone acetate is primarily used in research settings to study its effects on muscle growth, bone density, and its potential as a male contraceptive. Its potent anabolic effects make it a subject of interest for understanding muscle wasting conditions and other disorders related to androgen deficiency.

Potential Applications[edit]

Research into trestolone acetate has explored its use as a male contraceptive due to its ability to suppress spermatogenesis while maintaining androgenic effects. It is also being studied for its potential in treating conditions such as hypogonadism and muscle wasting diseases.

Side Effects[edit]

Like other anabolic steroids, trestolone acetate can cause a range of side effects. These may include acne, gynecomastia, hypertension, and alterations in lipid profile. Long-term use can lead to liver damage and cardiovascular disease.

Related Pages[edit]