Arteriosclerosis obliterans

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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Arteriosclerosis obliterans
Synonyms	Peripheral artery disease, peripheral vascular disease
Pronounce	N/A
Specialty	Vascular surgery, Cardiology
Symptoms	Claudication, leg pain, cold feet, ulcers
Complications	Gangrene, amputation, heart attack, stroke
Onset	Typically after age 50
Duration	Long-term
Types	N/A
Causes	Atherosclerosis, smoking, diabetes, hypertension, high cholesterol
Risks	Smoking, diabetes, high blood pressure, high cholesterol, obesity
Diagnosis	Ankle-brachial index, Doppler ultrasound, angiography
Differential diagnosis	Deep vein thrombosis, spinal stenosis, arthritis
Prevention	Smoking cessation, exercise, healthy diet, cholesterol management
Treatment	Lifestyle changes, medications, angioplasty, bypass surgery
Medication	Statins, antiplatelet drugs, cilostazol
Prognosis	Variable, depends on severity and treatment
Frequency	Common in older adults
Deaths	N/A

A condition characterized by the thickening and hardening of the walls of the arteries, leading to reduced blood flow.

Arteriosclerosis Obliterans

Diagram of an artery showing arteriosclerosis.

Arteriosclerosis obliterans is a form of arteriosclerosis involving the progressive thickening and hardening of the walls of the arteries. This condition leads to the narrowing and eventual blockage of the arteries, which can significantly reduce blood flow to various parts of the body.

Pathophysiology

Arteriosclerosis obliterans primarily affects the peripheral arteries, particularly those supplying the lower extremities. The disease process involves the buildup of atherosclerotic plaques within the arterial walls. These plaques are composed of lipids, calcium, and other substances found in the blood. Over time, the plaques harden and narrow the arterial lumen, impeding blood flow.

Clinical Manifestations

The symptoms of arteriosclerosis obliterans depend on the severity and location of the arterial blockage. Common symptoms include:

• Intermittent claudication: Pain and cramping in the legs during exercise, which is relieved by rest.
• Rest pain: Persistent pain in the feet or toes, especially at night.
• Ulceration and gangrene: Severe cases may lead to tissue death due to lack of blood supply.

Diagnosis

The diagnosis of arteriosclerosis obliterans is typically made through a combination of clinical evaluation and diagnostic tests. These may include:

• Ankle-brachial index (ABI): A simple test comparing blood pressure in the ankle and arm.
• Doppler ultrasound: To assess blood flow in the arteries.
• Angiography: Imaging technique to visualize the arteries and identify blockages.

Treatment

Treatment for arteriosclerosis obliterans aims to relieve symptoms and prevent further progression of the disease. Options include:

• Lifestyle modifications: Smoking cessation, exercise, and dietary changes.
• Medications: Such as antiplatelet agents, statins, and vasodilators.
• Surgical interventions: Including angioplasty, stenting, or bypass surgery for severe cases.

Prevention

Preventive measures focus on reducing risk factors associated with arteriosclerosis. These include:

• Maintaining a healthy diet low in saturated fats and cholesterol.
• Regular physical activity.
• Controlling hypertension, diabetes, and hyperlipidemia.

See also

• Atherosclerosis
• Peripheral artery disease
• Cardiovascular disease