Stercuronium iodide: Difference between revisions

Latest revision as of 05:20, 16 February 2025

Stercuronium Iodide[edit]

Stercuronium iodide is a quaternary ammonium compound that is used as a neuromuscular-blocking drug. It is a type of non-depolarizing neuromuscular blocker, which means it works by inhibiting the action of acetylcholine at the neuromuscular junction, preventing muscle contraction.

Mechanism of Action[edit]

Stercuronium iodide functions by competitively binding to the nicotinic acetylcholine receptor at the neuromuscular junction. This prevents acetylcholine from binding to the receptor, thereby inhibiting the depolarization of the muscle cell membrane and subsequent muscle contraction. As a result, it causes muscle relaxation and is used during surgical procedures to facilitate endotracheal intubation and provide optimal surgical conditions.

Pharmacokinetics[edit]

Stercuronium iodide is administered intravenously. It has a rapid onset of action and a duration of effect that is intermediate compared to other neuromuscular blockers. The drug is metabolized in the liver and excreted primarily through the kidneys.

Clinical Use[edit]

In clinical settings, stercuronium iodide is used to induce muscle relaxation during general anesthesia. It is particularly useful in procedures that require muscle paralysis, such as abdominal surgery or orthopedic surgery. The drug is also used in intensive care units to facilitate mechanical ventilation in patients who require prolonged respiratory support.

Side Effects[edit]

Common side effects of stercuronium iodide include hypotension, tachycardia, and bronchospasm. As with other neuromuscular blockers, there is a risk of prolonged paralysis and respiratory depression if the drug is not properly monitored. Anaphylaxis is a rare but serious adverse reaction.

Related Pages[edit]

@@ Line 1: / Line 1: @@
-'''Stercuronium iodide''' is a [[muscle relaxant]] used in [[anesthesia]] to facilitate [[tracheal intubation]], and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is a non-depolarizing [[neuromuscular-blocking drug]] (NMBD) and [[antagonist]] that blocks the action of [[acetylcholine]] (ACh) at the neuromuscular junction, leading to paralysis of the affected skeletal muscles.
+== Stercuronium Iodide ==
-==Pharmacology==
+[[File:Stercuronium_iodide.png|thumb|right|Chemical structure of Stercuronium Iodide]]
-Stercuronium iodide is a [[competitive antagonist]] at the [[nicotinic acetylcholine receptor]], the receptor for the neurotransmitter acetylcholine, which is responsible for transmitting signals from nerves to muscles. By blocking these receptors, stercuronium iodide prevents the muscles from receiving these signals, leading to muscle relaxation and paralysis.
-==Clinical Use==
+'''Stercuronium iodide''' is a [[quaternary ammonium compound]] that is used as a [[neuromuscular-blocking drug]]. It is a type of [[non-depolarizing neuromuscular blocker]], which means it works by inhibiting the action of [[acetylcholine]] at the [[neuromuscular junction]], preventing [[muscle contraction]].
-Stercuronium iodide is used in a clinical setting primarily during surgery and in critical care, to allow for tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is often used in conjunction with other anesthetics.
-==Side Effects==
+== Mechanism of Action ==
-Like all medicines, stercuronium iodide can cause side effects, although not everybody gets them. Some of the common side effects include [[hypotension]] (low blood pressure), [[bradycardia]] (slow heart rate), and [[anaphylaxis]] (a severe allergic reaction).
-==History==
+Stercuronium iodide functions by competitively binding to the [[nicotinic acetylcholine receptor]] at the neuromuscular junction. This prevents acetylcholine from binding to the receptor, thereby inhibiting the depolarization of the [[muscle cell membrane]] and subsequent muscle contraction. As a result, it causes [[muscle relaxation]] and is used during [[surgical procedures]] to facilitate [[endotracheal intubation]] and provide optimal surgical conditions.
-Stercuronium iodide was first synthesized in the 1960s as part of a series of muscle relaxants. It is no longer widely used, having been largely replaced by newer and more effective drugs.
+== Pharmacokinetics ==
+Stercuronium iodide is administered intravenously. It has a rapid onset of action and a duration of effect that is intermediate compared to other neuromuscular blockers. The drug is metabolized in the [[liver]] and excreted primarily through the [[kidneys]].
+== Clinical Use ==
+In clinical settings, stercuronium iodide is used to induce muscle relaxation during [[general anesthesia]]. It is particularly useful in procedures that require [[muscle paralysis]], such as [[abdominal surgery]] or [[orthopedic surgery]]. The drug is also used in [[intensive care units]] to facilitate [[mechanical ventilation]] in patients who require prolonged respiratory support.
+== Side Effects ==
+Common side effects of stercuronium iodide include [[hypotension]], [[tachycardia]], and [[bronchospasm]]. As with other neuromuscular blockers, there is a risk of [[prolonged paralysis]] and [[respiratory depression]] if the drug is not properly monitored. [[Anaphylaxis]] is a rare but serious adverse reaction.
+== Related Pages ==
-==See Also==
 * [[Neuromuscular-blocking drug]]
-* [[Anesthesia]]
+* [[Quaternary ammonium compound]]
-* [[Tracheal intubation]]
+* [[Acetylcholine]]
+* [[Nicotinic acetylcholine receptor]]
+* [[General anesthesia]]
-[[Category:Muscle relaxants]]
+[[Category:Neuromuscular blockers]]
-[[Category:Neuromuscular blocking agents]]
+[[Category:Quaternary ammonium compounds]]
-[[Category:Iodides]]
-{{medicine-stub}}