Pazufloxacin: Difference between revisions

Pazufloxacin
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Latest revision as of 01:23, 20 February 2025

An article about the antibiotic Pazufloxacin

Pazufloxacin is a fluoroquinolone antibiotic used in the treatment of various bacterial infections. It is particularly effective against Gram-negative bacteria and is often used in clinical settings for its broad-spectrum activity.

Mechanism of Action[edit]

Pazufloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. This inhibition leads to the disruption of bacterial DNA synthesis, ultimately resulting in bacterial cell death.

Pharmacokinetics[edit]

Pazufloxacin is administered intravenously, allowing for rapid distribution throughout the body. It is known for its high tissue penetration, making it effective in treating infections in various body sites. The drug is primarily excreted through the renal system, and its half-life allows for convenient dosing schedules.

Clinical Uses[edit]

Pazufloxacin is used to treat a variety of infections, including:

Side Effects[edit]

Common side effects of pazufloxacin include nausea, vomiting, and diarrhea. More serious side effects can include tendonitis and tendon rupture, particularly in older patients or those on concurrent corticosteroid therapy.

Contraindications[edit]

Pazufloxacin should not be used in patients with a known hypersensitivity to quinolones. Caution is advised in patients with a history of seizures or central nervous system disorders.

Related pages[edit]

Pazufloxacin

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-'''Pazufloxacin''' is a [[fluoroquinolone]] [[antibiotic]] used in the treatment of [[bacterial infections]]. It is a broad-spectrum antibiotic, meaning it is effective against a wide range of bacteria. Pazufloxacin is often used in the treatment of [[urinary tract infections]], [[respiratory tract infections]], and [[skin and soft tissue infections]].
+{{Short description|An article about the antibiotic Pazufloxacin}}
+{{Drugbox
+| verifiedrevid = 123456789
+| image = Pazufloxacin.svg
+| image_size = 200px
+| image_alt = Structural formula of Pazufloxacin
+}}
+'''Pazufloxacin''' is a [[fluoroquinolone]] [[antibiotic]] used in the treatment of various bacterial infections. It is particularly effective against [[Gram-negative bacteria]] and is often used in clinical settings for its broad-spectrum activity.
 ==Mechanism of Action==
-Pazufloxacin works by inhibiting the [[DNA gyrase]] and [[topoisomerase IV]], enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This inhibition prevents the bacteria from reproducing and eventually leads to their death.
+Pazufloxacin works by inhibiting bacterial [[DNA gyrase]] and [[topoisomerase IV]], enzymes critical for [[DNA replication]] and [[transcription (genetics)|transcription]]. This inhibition leads to the disruption of bacterial [[DNA synthesis]], ultimately resulting in bacterial cell death.
 ==Pharmacokinetics==
-After oral administration, Pazufloxacin is rapidly absorbed from the gastrointestinal tract. It is widely distributed throughout the body, including tissues and body fluids. The drug is primarily excreted in the urine as unchanged drug.
+Pazufloxacin is administered intravenously, allowing for rapid distribution throughout the body. It is known for its high tissue penetration, making it effective in treating infections in various body sites. The drug is primarily excreted through the [[renal system]], and its half-life allows for convenient dosing schedules.
+==Clinical Uses==
+Pazufloxacin is used to treat a variety of infections, including:
+* [[Urinary tract infections]]
+* [[Respiratory tract infections]]
+* [[Intra-abdominal infections]]
+* [[Skin and soft tissue infections]]
 ==Side Effects==
-Like all medications, Pazufloxacin can cause side effects. Common side effects include [[nausea]], [[diarrhea]], and [[abdominal pain]]. Less common but more serious side effects can include [[allergic reactions]], [[liver damage]], and [[neuropathy]].
+Common side effects of pazufloxacin include [[nausea]], [[vomiting]], and [[diarrhea]]. More serious side effects can include [[tendonitis]] and [[tendon rupture]], particularly in older patients or those on concurrent [[corticosteroid]] therapy.
-==Precautions==
+==Contraindications==
-Patients with a history of [[hypersensitivity]] to quinolone antibiotics should avoid using Pazufloxacin. It should also be used with caution in patients with a history of [[seizures]] or other central nervous system disorders due to the risk of seizure induction.
+Pazufloxacin should not be used in patients with a known hypersensitivity to [[quinolones]]. Caution is advised in patients with a history of [[seizures]] or [[central nervous system]] disorders.
-==Interactions==
+==Related pages==
-Pazufloxacin can interact with other medications, including [[antacids]], [[iron supplements]], and [[multivitamins]] containing zinc or iron. These can reduce the absorption of Pazufloxacin, reducing its effectiveness.
+* [[Antibiotic]]
-==See Also==
 * [[Fluoroquinolone]]
-* [[Antibiotic]]
+* [[Bacterial infection]]
-* [[DNA gyrase]]
-* [[Topoisomerase IV]]
 [[Category:Antibiotics]]
 [[Category:Fluoroquinolones]]
-{{medicine-stub}}
+<gallery>
+File:Pazufloxacin.svg|Pazufloxacin
+</gallery>