Para-Fluorophenylpiperazine: Difference between revisions

Latest revision as of 14:12, 21 February 2025

Para-Fluorophenylpiperazine

Para-Fluorophenylpiperazine (pFPP) is a chemical compound belonging to the piperazine class. It is a derivative of phenylpiperazine and is known for its psychoactive properties. pFPP has been used in scientific research and has also appeared in the recreational drug market.

Chemical Structure and Properties[edit]

Para-Fluorophenylpiperazine is characterized by the presence of a fluorine atom at the para position of the phenyl ring attached to the piperazine moiety. This structural modification influences its pharmacological activity and receptor binding profile.

The molecular formula of pFPP is C₁₀H₁₃FN₂, and it has a molecular weight of 180.22 g/mol. The compound is typically synthesized through the reaction of piperazine with para-fluorobenzene.

Pharmacology[edit]

pFPP acts primarily as a serotonin receptor agonist, with a particular affinity for the 5-HT_1A and 5-HT_2A receptors. This activity is responsible for its psychoactive effects, which can include mood enhancement, mild euphoria, and altered perception.

The compound's interaction with serotonin receptors is similar to that of other phenylpiperazine derivatives, such as mCPP and TFMPP. However, the presence of the fluorine atom in pFPP alters its potency and selectivity.

Uses and Effects[edit]

In research settings, para-Fluorophenylpiperazine is used to study the effects of serotonin receptor agonists on the central nervous system. It serves as a tool for understanding the role of serotonin in mood regulation and other neurological processes.

Recreationally, pFPP has been used as a designer drug, often found in "party pills" or "herbal highs." Users report effects such as increased sociability, enhanced mood, and mild hallucinations. However, it can also cause adverse effects like anxiety, nausea, and headaches.

Legal Status[edit]

The legal status of para-Fluorophenylpiperazine varies by country. In some regions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. In others, it remains unregulated, although its sale and distribution may be restricted under analog laws.

Safety and Toxicity[edit]

The safety profile of pFPP is not well-established, and its long-term effects are not fully understood. Acute toxicity is generally low, but high doses can lead to severe side effects, including serotonin syndrome, a potentially life-threatening condition.

Related Compounds[edit]

Para-Fluorophenylpiperazine is part of a broader class of phenylpiperazine derivatives, which includes:

mCPP (meta-Chlorophenylpiperazine)
TFMPP (Trifluoromethylphenylpiperazine)
BZP (Benzylpiperazine)

These compounds share similar pharmacological properties and are often studied together in research on serotonin receptor agonists.

Related Pages[edit]

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-'''Para-Fluorophenylpiperazine''' ('''pFPP''') is a [[piperazine]] derivative that is used in scientific research. It is a [[fluorinated]] compound, which means it contains a [[fluorine]] atom. pFPP is known for its [[serotonin receptor]] agonist activity, particularly at the 5-HT1A and 5-HT2A receptors.
+Para-Fluorophenylpiperazine
-==Chemistry==
+[[File:PFPP.svg|thumb|right|Chemical structure of para-Fluorophenylpiperazine]]
-Para-Fluorophenylpiperazine is a member of the [[piperazine]] class of compounds. Piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. This functional group consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring.
+'''Para-Fluorophenylpiperazine''' ('''pFPP''') is a chemical compound belonging to the [[piperazine]] class. It is a derivative of [[phenylpiperazine]] and is known for its psychoactive properties. pFPP has been used in scientific research and has also appeared in the recreational drug market.
-The term "para-fluorophenyl" refers to the specific substitution pattern of the phenyl ring. In this case, the fluorine atom is attached to the phenyl ring at the para position, which is the position directly across from the attachment point of the phenyl ring to the piperazine ring.
+==Chemical Structure and Properties==
+Para-Fluorophenylpiperazine is characterized by the presence of a [[fluorine]] atom at the para position of the phenyl ring attached to the piperazine moiety. This structural modification influences its pharmacological activity and receptor binding profile.
+The molecular formula of pFPP is C<sub>10</sub>H<sub>13</sub>FN<sub>2</sub>, and it has a molecular weight of 180.22 g/mol. The compound is typically synthesized through the reaction of [[piperazine]] with para-fluorobenzene.
 ==Pharmacology==
-pFPP acts as a [[serotonin receptor]] agonist. Serotonin receptors are a group of [[G protein-coupled receptor]]s and [[ligand-gated ion channels]] found in the [[central nervous system]] and [[peripheral nervous system]]. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the [[neurotransmitter]] serotonin, which acts as their natural ligand.
+pFPP acts primarily as a [[serotonin receptor]] agonist, with a particular affinity for the 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors. This activity is responsible for its psychoactive effects, which can include mood enhancement, mild euphoria, and altered perception.
+The compound's interaction with serotonin receptors is similar to that of other phenylpiperazine derivatives, such as [[mCPP]] and [[TFMPP]]. However, the presence of the fluorine atom in pFPP alters its potency and selectivity.
-pFPP has been found to have a high affinity for the 5-HT1A and 5-HT2A receptors. The 5-HT1A receptor is a subtype of serotonin receptor that is thought to play a significant role in [[anxiety]], [[depression]], and [[schizophrenia]]. The 5-HT2A receptor is primarily found in the [[cerebral cortex]] and is thought to play a key role in the cognitive functions of the brain, particularly in [[memory]] and [[learning]].
+==Uses and Effects==
-==Research Use==
+In research settings, para-Fluorophenylpiperazine is used to study the effects of serotonin receptor agonists on the central nervous system. It serves as a tool for understanding the role of serotonin in mood regulation and other neurological processes.
-Due to its activity at the serotonin receptors, pFPP is used in scientific research to study the role of these receptors in various neurological and psychiatric disorders. It can be used as a tool to better understand the function of the serotonin system in the brain and how it may be implicated in conditions such as depression, anxiety, and schizophrenia.
+Recreationally, pFPP has been used as a designer drug, often found in "party pills" or "herbal highs." Users report effects such as increased sociability, enhanced mood, and mild hallucinations. However, it can also cause adverse effects like anxiety, nausea, and headaches.
-==See Also==
+==Legal Status==
+The legal status of para-Fluorophenylpiperazine varies by country. In some regions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. In others, it remains unregulated, although its sale and distribution may be restricted under analog laws.
+==Safety and Toxicity==
+The safety profile of pFPP is not well-established, and its long-term effects are not fully understood. Acute toxicity is generally low, but high doses can lead to severe side effects, including [[serotonin syndrome]], a potentially life-threatening condition.
+==Related Compounds==
+Para-Fluorophenylpiperazine is part of a broader class of phenylpiperazine derivatives, which includes:
+* [[mCPP]] (meta-Chlorophenylpiperazine)
+* [[TFMPP]] (Trifluoromethylphenylpiperazine)
+* [[BZP]] (Benzylpiperazine)
+These compounds share similar pharmacological properties and are often studied together in research on serotonin receptor agonists.
+==Related Pages==
 * [[Piperazine]]
 * [[Serotonin receptor]]
-* [[5-HT1A receptor]]
+* [[Designer drug]]
-* [[5-HT2A receptor]]
+[[File:PFPP3d.png|thumb|left|3D model of para-Fluorophenylpiperazine]]
+{{Psychoactive drugs}}
-[[Category:Chemical compounds]]
+[[Category:Piperazines]]
-[[Category:Pharmacology]]
+[[Category:Designer drugs]]
-[[Category:Neuroscience]]
-{{Chem-stub}}
-{{Pharma-stub}}