Enrofloxacin: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{Short description|An antibiotic used in veterinary medicine}} | |||
[[File:Enrofloxacin_structure.svg|thumb|right|Chemical structure of Enrofloxacin]] | |||
Enrofloxacin | '''Enrofloxacin''' is a [[fluoroquinolone]] antibiotic used in [[veterinary medicine]] to treat a variety of [[bacterial infections]] in animals. It is effective against both [[Gram-positive bacteria|Gram-positive]] and [[Gram-negative bacteria|Gram-negative]] bacteria, making it a broad-spectrum antibiotic. | ||
== Mechanism of Action == | ==Mechanism of Action== | ||
Enrofloxacin works by inhibiting bacterial [[DNA gyrase]] and [[topoisomerase IV]], enzymes that are essential for [[DNA replication]] and [[transcription (genetics)|transcription]]. This inhibition leads to the disruption of bacterial [[DNA synthesis]], ultimately causing bacterial cell death. | |||
Enrofloxacin | ==Pharmacokinetics== | ||
Enrofloxacin is well absorbed after oral administration and is widely distributed throughout the body. It penetrates tissues and body fluids, including the [[central nervous system]], [[lungs]], and [[urinary tract]]. The drug is metabolized in the liver to form [[ciprofloxacin]], which also has antibacterial activity. | |||
== Uses == | ==Uses in Veterinary Medicine== | ||
Enrofloxacin is commonly used to treat infections in [[companion animals]] such as [[dogs]], [[cats]], and [[birds]], as well as in [[livestock]] including [[cattle]], [[pigs]], and [[poultry]]. It is effective against infections of the [[respiratory tract]], [[urinary tract]], [[gastrointestinal tract]], and [[skin]]. | |||
==Side Effects== | |||
While enrofloxacin is generally well tolerated, it can cause side effects in some animals. Common side effects include [[gastrointestinal upset]], such as [[vomiting]] and [[diarrhea]]. In young animals, enrofloxacin can affect [[cartilage]] development, leading to [[joint pain]] and [[lameness]]. | |||
== | ==Resistance== | ||
The use of enrofloxacin, like other antibiotics, can lead to the development of [[antibiotic resistance]]. It is important to use this medication judiciously and only when prescribed by a [[veterinarian]]. | |||
==Related pages== | |||
* [[Fluoroquinolone]] | * [[Fluoroquinolone]] | ||
* [[Antibiotic resistance]] | * [[Antibiotic resistance]] | ||
* [[Veterinary medicine]] | * [[Veterinary medicine]] | ||
[[Category:Antibiotics]] | |||
[[Category:Veterinary drugs]] | [[Category:Veterinary drugs]] | ||
Latest revision as of 11:19, 15 February 2025
An antibiotic used in veterinary medicine
Enrofloxacin is a fluoroquinolone antibiotic used in veterinary medicine to treat a variety of bacterial infections in animals. It is effective against both Gram-positive and Gram-negative bacteria, making it a broad-spectrum antibiotic.
Mechanism of Action[edit]
Enrofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for DNA replication and transcription. This inhibition leads to the disruption of bacterial DNA synthesis, ultimately causing bacterial cell death.
Pharmacokinetics[edit]
Enrofloxacin is well absorbed after oral administration and is widely distributed throughout the body. It penetrates tissues and body fluids, including the central nervous system, lungs, and urinary tract. The drug is metabolized in the liver to form ciprofloxacin, which also has antibacterial activity.
Uses in Veterinary Medicine[edit]
Enrofloxacin is commonly used to treat infections in companion animals such as dogs, cats, and birds, as well as in livestock including cattle, pigs, and poultry. It is effective against infections of the respiratory tract, urinary tract, gastrointestinal tract, and skin.
Side Effects[edit]
While enrofloxacin is generally well tolerated, it can cause side effects in some animals. Common side effects include gastrointestinal upset, such as vomiting and diarrhea. In young animals, enrofloxacin can affect cartilage development, leading to joint pain and lameness.
Resistance[edit]
The use of enrofloxacin, like other antibiotics, can lead to the development of antibiotic resistance. It is important to use this medication judiciously and only when prescribed by a veterinarian.
