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'''Bolenol''' is a [[synthetic steroid]] that is part of the [[anabolic steroid]] class of drugs. It is also known as 17α-ethyl-19-nortestosterone or as 17α-ethyl-19-norandrost-4-en-17β-ol-3-one. Bolenol is a derivative of [[nandrolone]] (19-nortestosterone) which has been ethylated at the 17α position.
{{Short description|Overview of the pharmaceutical drug Bolenol}}
{{Drugbox}}


== History ==
==Overview==
'''Bolenol''' is a synthetic [[anabolic steroid]] that is primarily used in the treatment of certain medical conditions such as [[muscle wasting]] and [[osteoporosis]]. It is known for its ability to promote muscle growth and increase bone density. Bolenol is often administered in clinical settings under strict medical supervision due to its potent effects and potential side effects.


Bolenol was first described in the scientific literature in 1963. It was developed by the pharmaceutical company [[Searle Laboratories]], which is now part of [[Pfizer]]. Bolenol was never marketed, and it is not currently approved for medical use.
==Chemical Properties==
Bolenol is a derivative of [[testosterone]], the primary male [[sex hormone]] and [[anabolic steroid]]. It has been chemically modified to enhance its anabolic properties while minimizing its androgenic effects. The molecular structure of Bolenol allows it to bind effectively to [[androgen receptors]], facilitating its role in muscle and bone tissue development.


== Pharmacology ==
==Medical Uses==
Bolenol is prescribed for patients suffering from conditions that lead to severe muscle loss, such as [[cachexia]] associated with [[cancer]] or [[HIV/AIDS]]. It is also used in the management of [[osteoporosis]] to help increase bone mass and reduce the risk of fractures. In some cases, Bolenol may be used off-label for other conditions as determined by a healthcare provider.


As an anabolic steroid, bolenol has the potential to increase muscle mass and strength. It is thought to work by binding to the [[androgen receptor]], which then influences the expression of certain genes in muscle cells. This can lead to increased protein synthesis and muscle growth.
==Mechanism of Action==
Bolenol works by mimicking the effects of naturally occurring [[androgens]]. It binds to androgen receptors in muscle and bone tissues, stimulating protein synthesis and promoting the growth of muscle fibers. This action helps in increasing muscle mass and strength. Additionally, Bolenol enhances the retention of [[calcium]] in bones, contributing to increased bone density.


Bolenol is a [[prodrug]] of nandrolone, meaning it is converted into nandrolone in the body. Nandrolone is a potent anabolic steroid that is also used in medicine to treat conditions such as [[anemia]] and [[osteoporosis]].
==Side Effects==
Like other anabolic steroids, Bolenol can cause a range of side effects. Common side effects include [[acne]], [[hair loss]], and [[mood swings]]. Long-term use can lead to more serious health issues such as [[liver damage]], [[cardiovascular disease]], and [[hormonal imbalances]]. It is crucial for patients to be monitored regularly by healthcare professionals while using Bolenol.


== Side Effects ==
==Legal Status==
The use of Bolenol is regulated in many countries due to its potential for abuse and the associated health risks. It is classified as a controlled substance in several jurisdictions, and its use is restricted to medical prescriptions. Non-medical use of Bolenol, particularly in sports, is prohibited by most athletic organizations.


The potential side effects of bolenol are similar to those of other anabolic steroids. These can include [[acne]], [[hair loss]], [[gynecomastia]], and changes in mood or behavior. Long-term use can also lead to serious health problems such as [[liver damage]], [[heart disease]], and [[infertility]].
==Images==
 
[[File:Bolenol.png|thumb|right|Chemical structure of Bolenol]]
== Legal Status ==
 
In many countries, including the United States, bolenol is classified as a [[controlled substance]]. This means it is illegal to possess, use, or distribute without a prescription. It is also banned by many sports organizations due to its potential for performance enhancement.
 
== See Also ==


==Related Pages==
* [[Anabolic steroid]]
* [[Anabolic steroid]]
* [[Nandrolone]]
* [[Testosterone]]
* [[Searle Laboratories]]
* [[Muscle wasting]]
* [[Pfizer]]
* [[Osteoporosis]]


[[Category:Anabolic steroids]]
[[Category:Anabolic steroids]]
[[Category:Prodrugs]]
[[Category:Pharmaceutical drugs]]
[[Category:Controlled substances]]
{{pharm-stub}}

Latest revision as of 03:49, 13 February 2025

Overview of the pharmaceutical drug Bolenol


Bolenol
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Overview[edit]

Bolenol is a synthetic anabolic steroid that is primarily used in the treatment of certain medical conditions such as muscle wasting and osteoporosis. It is known for its ability to promote muscle growth and increase bone density. Bolenol is often administered in clinical settings under strict medical supervision due to its potent effects and potential side effects.

Chemical Properties[edit]

Bolenol is a derivative of testosterone, the primary male sex hormone and anabolic steroid. It has been chemically modified to enhance its anabolic properties while minimizing its androgenic effects. The molecular structure of Bolenol allows it to bind effectively to androgen receptors, facilitating its role in muscle and bone tissue development.

Medical Uses[edit]

Bolenol is prescribed for patients suffering from conditions that lead to severe muscle loss, such as cachexia associated with cancer or HIV/AIDS. It is also used in the management of osteoporosis to help increase bone mass and reduce the risk of fractures. In some cases, Bolenol may be used off-label for other conditions as determined by a healthcare provider.

Mechanism of Action[edit]

Bolenol works by mimicking the effects of naturally occurring androgens. It binds to androgen receptors in muscle and bone tissues, stimulating protein synthesis and promoting the growth of muscle fibers. This action helps in increasing muscle mass and strength. Additionally, Bolenol enhances the retention of calcium in bones, contributing to increased bone density.

Side Effects[edit]

Like other anabolic steroids, Bolenol can cause a range of side effects. Common side effects include acne, hair loss, and mood swings. Long-term use can lead to more serious health issues such as liver damage, cardiovascular disease, and hormonal imbalances. It is crucial for patients to be monitored regularly by healthcare professionals while using Bolenol.

Legal Status[edit]

The use of Bolenol is regulated in many countries due to its potential for abuse and the associated health risks. It is classified as a controlled substance in several jurisdictions, and its use is restricted to medical prescriptions. Non-medical use of Bolenol, particularly in sports, is prohibited by most athletic organizations.

Images[edit]

Chemical structure of Bolenol

Related Pages[edit]