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'''Dimetofrine''' is a [[vasoconstrictor]] and [[antihypotensive]] agent that is used in the treatment of [[hypotension]]. It is also known as ''Dimetofrin'' and ''Dimetofrine Pantothenate''.  
{{Short description|Overview of the sympathomimetic drug Dimetofrine}}
{{Drugbox
| image = Dimetofrine.png
| image_size = 250px
| image_alt = Chemical structure of Dimetofrine
| caption = Chemical structure of Dimetofrine
}}
 
'''Dimetofrine''' is a [[sympathomimetic drug]] that is primarily used for its [[cardiovascular]] effects. It is known to act as a [[vasopressor]] and is used in the management of certain types of [[hypotension]].


==Pharmacology==
==Pharmacology==
Dimetofrine is a synthetic [[sympathomimetic amine]] that primarily acts on [[alpha-adrenergic receptor|alpha-adrenergic receptors]]. It stimulates the [[sympathetic nervous system]], resulting in vasoconstriction. This increases [[blood pressure]] by reducing the diameter of blood vessels, which increases the resistance to blood flow.
Dimetofrine functions by stimulating the [[adrenergic receptors]], which are part of the [[sympathetic nervous system]]. This leads to an increase in [[heart rate]] and [[blood pressure]]. The drug is often used in clinical settings to treat [[orthostatic hypotension]] and other conditions where an increase in blood pressure is desired.


==Medical Uses==
==Mechanism of Action==
Dimetofrine is used in the treatment of hypotension, particularly in cases where the condition is caused by [[shock (circulatory)|shock]], [[anesthesia]], or [[sepsis]]. It can also be used to treat [[orthostatic hypotension]], a condition where blood pressure drops significantly when a person stands up from a sitting or lying position.
Dimetofrine acts primarily on the [[alpha-adrenergic receptors]], leading to [[vasoconstriction]] and an increase in peripheral vascular resistance. This action results in elevated blood pressure. Additionally, it may have some effects on [[beta-adrenergic receptors]], contributing to increased cardiac output.
 
==Clinical Uses==
Dimetofrine is indicated for the treatment of low blood pressure, particularly in cases where rapid intervention is necessary. It is often administered in a hospital setting under careful monitoring due to its potent effects on the cardiovascular system.


==Side Effects==
==Side Effects==
Like other sympathomimetic amines, Dimetofrine can cause a number of [[side effect]]s. These can include [[palpitations]], [[tachycardia]], [[arrhythmia]], and [[hypertension]]. In rare cases, it can cause severe [[cardiovascular]] events such as [[myocardial infarction]] or [[stroke]].
Common side effects of Dimetofrine include [[tachycardia]], [[palpitations]], and [[headache]]. Due to its vasopressor activity, it can also cause [[hypertension]] if not properly dosed. Patients may experience [[anxiety]] or [[nervousness]] as a result of increased sympathetic activity.


==Contraindications==
==Contraindications==
Dimetofrine is contraindicated in patients with [[hypertension]], [[hyperthyroidism]], and those with a history of [[hypersensitivity]] to sympathomimetic amines. It should also be used with caution in patients with [[coronary artery disease]] or other cardiovascular conditions.
Dimetofrine should not be used in patients with [[pheochromocytoma]], [[hyperthyroidism]], or severe [[hypertension]]. Caution is advised in patients with [[coronary artery disease]] or [[arrhythmias]].
 
==Administration==
Dimetofrine is typically administered intravenously in a clinical setting. The dosage is carefully titrated based on the patient's response and the severity of the hypotension being treated.


==See Also==
==Related pages==
* [[Vasoconstrictor]]
* [[Sympathomimetic drug]]
* [[Sympathomimetic drug]]
* [[Adrenergic receptor]]
* [[Vasopressor]]
* [[Hypotension]]
* [[Hypotension]]


[[Category:Drugs]]
[[Category:Sympathomimetic amines]]
[[Category:Vasoconstrictors]]
[[Category:Vasopressors]]
[[Category:Antihypotensive agents]]
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File:Dimetofrine.png|Dimetofrine
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Latest revision as of 01:00, 20 February 2025

Overview of the sympathomimetic drug Dimetofrine


Dimetofrine
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Dimetofrine is a sympathomimetic drug that is primarily used for its cardiovascular effects. It is known to act as a vasopressor and is used in the management of certain types of hypotension.

Pharmacology[edit]

Dimetofrine functions by stimulating the adrenergic receptors, which are part of the sympathetic nervous system. This leads to an increase in heart rate and blood pressure. The drug is often used in clinical settings to treat orthostatic hypotension and other conditions where an increase in blood pressure is desired.

Mechanism of Action[edit]

Dimetofrine acts primarily on the alpha-adrenergic receptors, leading to vasoconstriction and an increase in peripheral vascular resistance. This action results in elevated blood pressure. Additionally, it may have some effects on beta-adrenergic receptors, contributing to increased cardiac output.

Clinical Uses[edit]

Dimetofrine is indicated for the treatment of low blood pressure, particularly in cases where rapid intervention is necessary. It is often administered in a hospital setting under careful monitoring due to its potent effects on the cardiovascular system.

Side Effects[edit]

Common side effects of Dimetofrine include tachycardia, palpitations, and headache. Due to its vasopressor activity, it can also cause hypertension if not properly dosed. Patients may experience anxiety or nervousness as a result of increased sympathetic activity.

Contraindications[edit]

Dimetofrine should not be used in patients with pheochromocytoma, hyperthyroidism, or severe hypertension. Caution is advised in patients with coronary artery disease or arrhythmias.

Administration[edit]

Dimetofrine is typically administered intravenously in a clinical setting. The dosage is carefully titrated based on the patient's response and the severity of the hypotension being treated.

Related pages[edit]