Methylmethaqualone: Difference between revisions

Methylmethaqualone
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Latest revision as of 11:56, 15 February 2025

Overview of the drug Methylmethaqualone

Methylmethaqualone is a quinazolinone-class sedative and hypnotic drug that is structurally related to methaqualone. It was developed in the 1960s and has similar effects to methaqualone, including sedation, anxiolysis, and muscle relaxation.

Chemical structure and properties[edit]

Structural formula of Methylmethaqualone

Methylmethaqualone is a derivative of methaqualone, with a methyl group added to the nitrogen atom of the quinazolinone ring. This modification alters its pharmacokinetic properties, potentially affecting its potency and duration of action.

Pharmacology[edit]

Methylmethaqualone acts as a central nervous system depressant. It is believed to exert its effects by modulating GABA receptors, similar to other sedative-hypnotic drugs. This action results in increased inhibitory neurotransmission, leading to the drug's calming effects.

Medical use[edit]

Methylmethaqualone was initially developed for use as a sedative and hypnotic agent. However, due to concerns about its potential for abuse and addiction, its medical use has been limited. It is not commonly prescribed today and is considered a controlled substance in many countries.

Side effects[edit]

The side effects of methylmethaqualone are similar to those of other sedative-hypnotics and may include drowsiness, dizziness, nausea, and headache. In higher doses, it can cause more severe effects such as respiratory depression, hypotension, and coma.

Legal status[edit]

Due to its potential for abuse and addiction, methylmethaqualone is classified as a controlled substance in many jurisdictions. Its legal status varies by country, but it is generally subject to strict regulation.

Related compounds[edit]

Methylmethaqualone is chemically related to several other quinazolinone derivatives, including:

Related pages[edit]

@@ Line 1: / Line 1: @@
-'''Methylmethaqualone''' is a [[Quinazolinone|quinazolinone]] class [[GABAergic|GABAergic]] and is an analogue of [[methaqualone]] that was first made in 1965 and marketed mainly in France and some other European countries. It has [[sedative]], [[hypnotic]], and [[anxiolytic]] effects caused by its agonist activity at the β subtype of the [[GABA receptor]], and was used for the treatment of [[insomnia]].
+{{Short description|Overview of the drug Methylmethaqualone}}
+{{Drugbox
+| image = Methylmethaqualone.svg
+| image_size = 250px
+| image_alt = Structural formula of Methylmethaqualone
+}}
-== Pharmacology ==
+'''Methylmethaqualone''' is a [[quinazolinone]]-class [[sedative]] and [[hypnotic]] drug that is structurally related to [[methaqualone]]. It was developed in the 1960s and has similar effects to methaqualone, including [[sedation]], [[anxiolysis]], and [[muscle relaxation]].
-Methylmethaqualone differs from methaqualone by 3-methylation on the quinazoline. This makes it about twice as potent, and it was hoped it would be less addictive. However, it was still capable of causing [[dependence]] and serious side effects, and was therefore considered to be a [[controlled substance]] in many countries.
+==Chemical structure and properties==
+[[File:Methylmethaqualone.svg|thumb|right|Structural formula of Methylmethaqualone]]
+Methylmethaqualone is a derivative of methaqualone, with a methyl group added to the nitrogen atom of the quinazolinone ring. This modification alters its pharmacokinetic properties, potentially affecting its potency and duration of action.
-== History ==
+==Pharmacology==
+Methylmethaqualone acts as a [[central nervous system]] [[depressant]]. It is believed to exert its effects by modulating [[GABA]] receptors, similar to other sedative-hypnotic drugs. This action results in increased [[inhibitory neurotransmission]], leading to the drug's calming effects.
-Methylmethaqualone was developed in the mid-1960s as a safer alternative to barbiturates to treat anxiety and insomnia. However, it was still capable of causing dependence and serious side effects. It was scheduled as a controlled substance in many countries due to these issues.
+==Medical use==
+Methylmethaqualone was initially developed for use as a sedative and hypnotic agent. However, due to concerns about its potential for abuse and addiction, its medical use has been limited. It is not commonly prescribed today and is considered a [[controlled substance]] in many countries.
-== Side Effects ==
+==Side effects==
+The side effects of methylmethaqualone are similar to those of other sedative-hypnotics and may include [[drowsiness]], [[dizziness]], [[nausea]], and [[headache]]. In higher doses, it can cause more severe effects such as [[respiratory depression]], [[hypotension]], and [[coma]].
-The side effects of Methylmethaqualone include [[dizziness]], [[nausea]], [[vomiting]], and [[sweating]]. In severe cases, it can cause [[coma]] or [[death]].
+==Legal status==
+Due to its potential for abuse and addiction, methylmethaqualone is classified as a controlled substance in many jurisdictions. Its legal status varies by country, but it is generally subject to strict regulation.
-== Legal Status ==
-Methylmethaqualone is a controlled substance in many countries due to its potential for abuse and addiction. It is a Schedule I controlled substance in the United States.
-== See Also ==
+==Related compounds==
+Methylmethaqualone is chemically related to several other quinazolinone derivatives, including:
 * [[Methaqualone]]
-* [[Quinazolinone]]
+* [[Mecloqualone]]
-* [[GABAergic]]
+* [[Etaqualone]]
-[[Category:Drugs]]
+==Related pages==
-[[Category:Pharmacology]]
+* [[Sedative]]
-[[Category:Medicine]]
+* [[Hypnotic]]
+* [[Central nervous system depressant]]
-{{stub}}
+[[Category:Sedatives]]
+[[Category:Hypnotics]]
+[[Category:Quinazolinones]]