Dibekacin: Difference between revisions

Dibekacin
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Latest revision as of 00:59, 20 February 2025

An aminoglycoside antibiotic

Dibekacin is an aminoglycoside antibiotic used in the treatment of various bacterial infections. It is particularly effective against Gram-negative bacteria and is often used in clinical settings where other antibiotics may not be effective.

Mechanism of Action[edit]

Dibekacin works by binding to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis. This action is bactericidal, meaning it kills bacteria rather than merely inhibiting their growth. The binding interferes with the initiation complex of peptide formation, causing misreading of mRNA, which leads to the production of nonfunctional or toxic peptides.

Clinical Uses[edit]

Dibekacin is primarily used to treat serious infections caused by susceptible strains of bacteria. These include:

It is often reserved for use in hospital settings due to its potential for nephrotoxicity and ototoxicity, which are common side effects of aminoglycosides.

Administration[edit]

Dibekacin is usually administered via intravenous or intramuscular injection. The dosage and duration of treatment depend on the severity of the infection, the patient's renal function, and the susceptibility of the causative organism.

Side Effects[edit]

Common side effects of dibekacin include:

Patients receiving dibekacin should be monitored for signs of renal impairment and auditory damage. Dosage adjustments may be necessary in patients with pre-existing renal conditions.

Resistance[edit]

Bacterial resistance to dibekacin can occur through several mechanisms, including:

Enzymatic modification of the drug
Alteration of the ribosomal binding site
Efflux pumps that remove the drug from the bacterial cell

Related pages[edit]

Dibekacin

@@ Line 1: / Line 1: @@
-'''Dibekacin''' is an [[aminoglycoside]] [[antibiotic]] that is used in the treatment of various types of [[bacterial infections]]. It is derived from the bacterium ''[[Micromonospora]]'' and is particularly effective against [[Gram-negative bacteria]].
+{{Short description|An aminoglycoside antibiotic}}
+{{Drugbox
+| verifiedfields = changed
+| verifiedrevid = 477002123
+| image = Dibekacin.svg
+| image2 =
+}}
-== Mechanism of Action ==
+'''Dibekacin''' is an [[aminoglycoside]] [[antibiotic]] used in the treatment of various bacterial infections. It is particularly effective against [[Gram-negative bacteria]] and is often used in clinical settings where other antibiotics may not be effective.
-Dibekacin works by binding to the [[30S ribosomal subunit]] of the bacteria, which interferes with [[protein synthesis]]. This prevents the bacteria from growing and multiplying, thereby stopping the infection.
-== Uses ==
+==Mechanism of Action==
-Dibekacin is used to treat a variety of bacterial infections, including those caused by [[Escherichia coli]], [[Klebsiella pneumoniae]], and [[Pseudomonas aeruginosa]]. It is also used in the treatment of [[sepsis]], [[urinary tract infections]], and [[respiratory tract infections]].
+Dibekacin works by binding to the 30S subunit of the bacterial [[ribosome]], inhibiting protein synthesis. This action is bactericidal, meaning it kills bacteria rather than merely inhibiting their growth. The binding interferes with the initiation complex of peptide formation, causing misreading of mRNA, which leads to the production of nonfunctional or toxic peptides.
-== Side Effects ==
+==Clinical Uses==
-Like other aminoglycoside antibiotics, dibekacin can cause a number of side effects. These include [[ototoxicity]], which can lead to hearing loss, and [[nephrotoxicity]], which can cause kidney damage. Other potential side effects include [[nausea]], [[vomiting]], and [[rash]].
+Dibekacin is primarily used to treat serious infections caused by susceptible strains of bacteria. These include:
+* [[Sepsis]]
+* [[Pneumonia]]
+* [[Urinary tract infections]]
+* [[Intra-abdominal infections]]
-== Contraindications ==
+It is often reserved for use in hospital settings due to its potential for nephrotoxicity and ototoxicity, which are common side effects of aminoglycosides.
-Dibekacin is contraindicated in patients with a known hypersensitivity to aminoglycoside antibiotics. It should also be used with caution in patients with pre-existing kidney disease or hearing loss.
-== See Also ==
+==Administration==
+Dibekacin is usually administered via [[intravenous]] or [[intramuscular]] injection. The dosage and duration of treatment depend on the severity of the infection, the patient's renal function, and the susceptibility of the causative organism.
+==Side Effects==
+Common side effects of dibekacin include:
+* [[Nephrotoxicity]]
+* [[Ototoxicity]]
+* [[Neuromuscular blockade]]
+Patients receiving dibekacin should be monitored for signs of renal impairment and auditory damage. Dosage adjustments may be necessary in patients with pre-existing renal conditions.
+==Resistance==
+Bacterial resistance to dibekacin can occur through several mechanisms, including:
+* Enzymatic modification of the drug
+* Alteration of the ribosomal binding site
+* Efflux pumps that remove the drug from the bacterial cell
+==Related pages==
 * [[Aminoglycoside]]
-* [[Antibiotic]]
+* [[Antibiotic resistance]]
-* [[Bacterial Infections]]
+* [[Gram-negative bacteria]]
-* [[Protein Synthesis]]
+[[Category:Aminoglycoside antibiotics]]
 [[Category:Antibiotics]]
-[[Category:Aminoglycosides]]
+<gallery>
-[[Category:Medicine]]
+File:Dibekacin.svg|Dibekacin
+</gallery>
-{{stub}}