Pipemidic acid: Difference between revisions
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{{Short description|An article about the antibiotic pipemidic acid}} | |||
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'''Pipemidic acid''' is a [[quinolone]] [[antibiotic]] used primarily in the treatment of [[urinary tract infections]]. It belongs to the class of first-generation quinolones and is known for its activity against a range of [[Gram-negative bacteria]]. | |||
Pipemidic acid | |||
== | ==Chemical structure and properties== | ||
Pipemidic acid is | [[File:Pipemidic_acid.svg|thumb|right|200px|Chemical structure of pipemidic acid]] | ||
Pipemidic acid is a [[pyridopyrimidine]] derivative with a chemical structure that includes a [[piperazine]] ring. This structure is crucial for its antibacterial activity, allowing it to inhibit bacterial [[DNA gyrase]], an enzyme essential for [[DNA replication]] in bacteria. | |||
== | ==Mechanism of action== | ||
Pipemidic acid works by interfering with the [[DNA replication]] process of bacteria. It targets the [[DNA gyrase]] enzyme, which is responsible for supercoiling the DNA. By inhibiting this enzyme, pipemidic acid prevents the bacteria from replicating and repairing their DNA, leading to bacterial cell death. | |||
== | ==Clinical uses== | ||
Pipemidic acid | Pipemidic acid is primarily used to treat [[urinary tract infections]] caused by susceptible strains of bacteria. It is effective against a variety of [[Gram-negative bacteria]], including ''[[Escherichia coli]]'', ''[[Klebsiella pneumoniae]]'', and ''[[Proteus mirabilis]]''. However, it is not effective against [[Gram-positive bacteria]] or [[anaerobic bacteria]]. | ||
== | ==Side effects== | ||
Common side effects of pipemidic acid include [[gastrointestinal disturbances]] such as [[nausea]], [[vomiting]], and [[diarrhea]]. Some patients may experience [[allergic reactions]], including [[rash]] and [[pruritus]]. Rarely, it can cause [[central nervous system]] effects such as [[dizziness]] and [[headache]]. | |||
== | ==Pharmacokinetics== | ||
Pipemidic acid is well absorbed from the gastrointestinal tract and reaches peak plasma concentrations within 1 to 2 hours after oral administration. It is primarily excreted unchanged in the urine, which makes it particularly effective for treating urinary tract infections. | |||
==Resistance== | |||
Bacterial resistance to pipemidic acid can occur through mutations in the [[DNA gyrase]] gene or through the acquisition of [[plasmid-mediated resistance]] mechanisms. Resistance is more common in areas with high usage of quinolone antibiotics. | |||
==Related pages== | |||
* [[Quinolone]] | * [[Quinolone]] | ||
* [[Antibiotic]] | |||
* [[Urinary tract infection]] | * [[Urinary tract infection]] | ||
[[Category:Quinolone antibiotics]] | |||
[[Category:Urinary tract infections]] | |||
Latest revision as of 11:28, 15 February 2025
An article about the antibiotic pipemidic acid
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Pipemidic acid is a quinolone antibiotic used primarily in the treatment of urinary tract infections. It belongs to the class of first-generation quinolones and is known for its activity against a range of Gram-negative bacteria.
Chemical structure and properties[edit]
Pipemidic acid is a pyridopyrimidine derivative with a chemical structure that includes a piperazine ring. This structure is crucial for its antibacterial activity, allowing it to inhibit bacterial DNA gyrase, an enzyme essential for DNA replication in bacteria.
Mechanism of action[edit]
Pipemidic acid works by interfering with the DNA replication process of bacteria. It targets the DNA gyrase enzyme, which is responsible for supercoiling the DNA. By inhibiting this enzyme, pipemidic acid prevents the bacteria from replicating and repairing their DNA, leading to bacterial cell death.
Clinical uses[edit]
Pipemidic acid is primarily used to treat urinary tract infections caused by susceptible strains of bacteria. It is effective against a variety of Gram-negative bacteria, including Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. However, it is not effective against Gram-positive bacteria or anaerobic bacteria.
Side effects[edit]
Common side effects of pipemidic acid include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Some patients may experience allergic reactions, including rash and pruritus. Rarely, it can cause central nervous system effects such as dizziness and headache.
Pharmacokinetics[edit]
Pipemidic acid is well absorbed from the gastrointestinal tract and reaches peak plasma concentrations within 1 to 2 hours after oral administration. It is primarily excreted unchanged in the urine, which makes it particularly effective for treating urinary tract infections.
Resistance[edit]
Bacterial resistance to pipemidic acid can occur through mutations in the DNA gyrase gene or through the acquisition of plasmid-mediated resistance mechanisms. Resistance is more common in areas with high usage of quinolone antibiotics.
