Krukenberg tumor: Difference between revisions
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{{SI}} | |||
{{Infobox medical condition | |||
| name = Krukenberg tumor | |||
| image = [[File:Gross_pathology_and_histopathology_of_signet_ring_cell_carcinoma_metastasis_to_the_ovary.jpg|250px]] | |||
| caption = Gross pathology and histopathology of signet ring cell carcinoma metastasis to the ovary | |||
| field = [[Oncology]] | |||
| synonyms = Krukenberg tumor | |||
| symptoms = Abdominal pain, bloating, pelvic mass | |||
| complications = [[Ascites]], [[intestinal obstruction]] | |||
| onset = Typically in women aged 40-60 | |||
| duration = Variable | |||
| causes = Metastasis from a primary [[gastrointestinal tract]] cancer, often [[stomach cancer]] | |||
| risks = Family history of [[gastric cancer]], [[genetic predisposition]] | |||
| diagnosis = [[Histopathology]], [[imaging studies]] | |||
| differential = [[Primary ovarian cancer]], [[benign ovarian tumor]] | |||
| prevention = None specific, early detection of primary cancer | |||
| treatment = [[Surgery]], [[chemotherapy]] | |||
| prognosis = Generally poor, depends on primary cancer | |||
| frequency = Rare | |||
}} | |||
'''Krukenberg tumor''' is a type of [[metastatic cancer]] that primarily originates from the [[stomach]], but can also arise from other parts of the body such as the [[gallbladder]], [[colon]], [[breast]], and [[lung]]. It is named after Friedrich Ernst Krukenberg, who first described it in 1896. | '''Krukenberg tumor''' is a type of [[metastatic cancer]] that primarily originates from the [[stomach]], but can also arise from other parts of the body such as the [[gallbladder]], [[colon]], [[breast]], and [[lung]]. It is named after Friedrich Ernst Krukenberg, who first described it in 1896. | ||
==Epidemiology== | ==Epidemiology== | ||
Krukenberg tumors account for 1-2% of all [[ovarian tumors]], and are most commonly found in women between the ages of 40 and 50. However, they can occur at any age. | Krukenberg tumors account for 1-2% of all [[ovarian tumors]], and are most commonly found in women between the ages of 40 and 50. However, they can occur at any age. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The tumor is characterized by the presence of [[mucin]]-filled signet-ring cells in the [[ovary]]. These cells are typically derived from a primary [[adenocarcinoma]] located elsewhere in the body. The most common primary site is the stomach, followed by the colon, breast, and lung. | The tumor is characterized by the presence of [[mucin]]-filled signet-ring cells in the [[ovary]]. These cells are typically derived from a primary [[adenocarcinoma]] located elsewhere in the body. The most common primary site is the stomach, followed by the colon, breast, and lung. | ||
==Clinical Presentation== | ==Clinical Presentation== | ||
Patients with a Krukenberg tumor often present with [[abdominal pain]], [[bloating]], [[ascites]], and [[menstrual irregularities]]. In some cases, the tumor may be discovered incidentally during a routine [[pelvic examination]] or imaging study. | Patients with a Krukenberg tumor often present with [[abdominal pain]], [[bloating]], [[ascites]], and [[menstrual irregularities]]. In some cases, the tumor may be discovered incidentally during a routine [[pelvic examination]] or imaging study. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of a Krukenberg tumor is typically made based on the histological examination of a [[biopsy]] specimen. [[Imaging studies]] such as [[ultrasound]], [[computed tomography (CT) scan]], and [[magnetic resonance imaging (MRI)]] can also be helpful in identifying the primary tumor and assessing the extent of disease. | The diagnosis of a Krukenberg tumor is typically made based on the histological examination of a [[biopsy]] specimen. [[Imaging studies]] such as [[ultrasound]], [[computed tomography (CT) scan]], and [[magnetic resonance imaging (MRI)]] can also be helpful in identifying the primary tumor and assessing the extent of disease. | ||
==Treatment== | ==Treatment== | ||
The treatment of a Krukenberg tumor depends on the location and stage of the primary tumor, as well as the patient's overall health status. Treatment options may include [[surgery]], [[chemotherapy]], [[radiation therapy]], and [[targeted therapy]]. | The treatment of a Krukenberg tumor depends on the location and stage of the primary tumor, as well as the patient's overall health status. Treatment options may include [[surgery]], [[chemotherapy]], [[radiation therapy]], and [[targeted therapy]]. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis of a Krukenberg tumor is generally poor, with a median survival time of less than one year. Factors that may influence the prognosis include the stage of the primary tumor, the presence of other metastases, and the patient's overall health status. | The prognosis of a Krukenberg tumor is generally poor, with a median survival time of less than one year. Factors that may influence the prognosis include the stage of the primary tumor, the presence of other metastases, and the patient's overall health status. | ||
==See Also== | ==See Also== | ||
* [[Ovarian cancer]] | * [[Ovarian cancer]] | ||
| Line 26: | Line 39: | ||
* [[Breast cancer]] | * [[Breast cancer]] | ||
* [[Lung cancer]] | * [[Lung cancer]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Gynecology]] | [[Category:Gynecology]] | ||
[[Category:Pathology]] | [[Category:Pathology]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 21:32, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Krukenberg tumor | |
|---|---|
| |
| Synonyms | Krukenberg tumor |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Abdominal pain, bloating, pelvic mass |
| Complications | Ascites, intestinal obstruction |
| Onset | Typically in women aged 40-60 |
| Duration | Variable |
| Types | N/A |
| Causes | Metastasis from a primary gastrointestinal tract cancer, often stomach cancer |
| Risks | Family history of gastric cancer, genetic predisposition |
| Diagnosis | Histopathology, imaging studies |
| Differential diagnosis | Primary ovarian cancer, benign ovarian tumor |
| Prevention | None specific, early detection of primary cancer |
| Treatment | Surgery, chemotherapy |
| Medication | N/A |
| Prognosis | Generally poor, depends on primary cancer |
| Frequency | Rare |
| Deaths | N/A |
Krukenberg tumor is a type of metastatic cancer that primarily originates from the stomach, but can also arise from other parts of the body such as the gallbladder, colon, breast, and lung. It is named after Friedrich Ernst Krukenberg, who first described it in 1896.
Epidemiology[edit]
Krukenberg tumors account for 1-2% of all ovarian tumors, and are most commonly found in women between the ages of 40 and 50. However, they can occur at any age.
Pathophysiology[edit]
The tumor is characterized by the presence of mucin-filled signet-ring cells in the ovary. These cells are typically derived from a primary adenocarcinoma located elsewhere in the body. The most common primary site is the stomach, followed by the colon, breast, and lung.
Clinical Presentation[edit]
Patients with a Krukenberg tumor often present with abdominal pain, bloating, ascites, and menstrual irregularities. In some cases, the tumor may be discovered incidentally during a routine pelvic examination or imaging study.
Diagnosis[edit]
The diagnosis of a Krukenberg tumor is typically made based on the histological examination of a biopsy specimen. Imaging studies such as ultrasound, computed tomography (CT) scan, and magnetic resonance imaging (MRI) can also be helpful in identifying the primary tumor and assessing the extent of disease.
Treatment[edit]
The treatment of a Krukenberg tumor depends on the location and stage of the primary tumor, as well as the patient's overall health status. Treatment options may include surgery, chemotherapy, radiation therapy, and targeted therapy.
Prognosis[edit]
The prognosis of a Krukenberg tumor is generally poor, with a median survival time of less than one year. Factors that may influence the prognosis include the stage of the primary tumor, the presence of other metastases, and the patient's overall health status.
