Retroperitoneal fibrosis: Difference between revisions
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{{Infobox medical condition | |||
| name = Retroperitoneal fibrosis | |||
| synonyms = Ormond's disease | |||
| field = [[Rheumatology]], [[Nephrology]] | |||
| symptoms = [[Abdominal pain]], [[back pain]], [[weight loss]], [[nausea]], [[vomiting]], [[hypertension]], [[renal failure]] | |||
| complications = [[Kidney failure]], [[ureteral obstruction]] | |||
| onset = Typically between ages 40 and 60 | |||
| duration = Chronic | |||
| causes = Often [[idiopathic]], can be secondary to [[medications]], [[infections]], [[malignancies]], or [[autoimmune diseases]] | |||
| risks = [[Smoking]], [[male gender]], [[genetic predisposition]] | |||
| diagnosis = [[CT scan]], [[MRI]], [[biopsy]] | |||
| differential = [[Lymphoma]], [[sarcoma]], [[aortic aneurysm]] | |||
| treatment = [[Corticosteroids]], [[immunosuppressive drugs]], [[surgery]] | |||
| medication = [[Prednisone]], [[azathioprine]], [[mycophenolate mofetil]] | |||
| prognosis = Variable, depends on response to treatment | |||
| frequency = Rare | |||
}} | |||
'''Retroperitoneal fibrosis''' or '''Ormond's disease''' is a rare disorder characterized by the presence of inflammatory and fibrous tissue behind the [[peritoneum]], the membrane that lines the abdominal cavity. This fibrous tissue often surrounds the [[aorta]] and the [[ureters]], potentially causing abdominal pain and kidney damage. | '''Retroperitoneal fibrosis''' or '''Ormond's disease''' is a rare disorder characterized by the presence of inflammatory and fibrous tissue behind the [[peritoneum]], the membrane that lines the abdominal cavity. This fibrous tissue often surrounds the [[aorta]] and the [[ureters]], potentially causing abdominal pain and kidney damage. | ||
== Causes == | == Causes == | ||
The exact cause of retroperitoneal fibrosis is unknown. However, it is believed to be associated with certain autoimmune diseases, infections, and exposure to certain drugs or toxins. In some cases, it may be idiopathic, meaning it occurs without any identifiable cause. | The exact cause of retroperitoneal fibrosis is unknown. However, it is believed to be associated with certain autoimmune diseases, infections, and exposure to certain drugs or toxins. In some cases, it may be idiopathic, meaning it occurs without any identifiable cause. | ||
== Symptoms == | == Symptoms == | ||
The symptoms of retroperitoneal fibrosis can vary greatly depending on the individual and the severity of the condition. Common symptoms include: | The symptoms of retroperitoneal fibrosis can vary greatly depending on the individual and the severity of the condition. Common symptoms include: | ||
* Abdominal pain | * Abdominal pain | ||
* Back pain | * Back pain | ||
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* Nausea and vomiting | * Nausea and vomiting | ||
* Urinary symptoms such as increased frequency or urgency | * Urinary symptoms such as increased frequency or urgency | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of retroperitoneal fibrosis is often challenging due to its nonspecific symptoms. It typically involves a combination of medical history, physical examination, and imaging studies such as [[Computed tomography|CT]] or [[Magnetic resonance imaging|MRI]]. In some cases, a biopsy may be necessary to confirm the diagnosis. | Diagnosis of retroperitoneal fibrosis is often challenging due to its nonspecific symptoms. It typically involves a combination of medical history, physical examination, and imaging studies such as [[Computed tomography|CT]] or [[Magnetic resonance imaging|MRI]]. In some cases, a biopsy may be necessary to confirm the diagnosis. | ||
== Treatment == | == Treatment == | ||
Treatment for retroperitoneal fibrosis typically involves medications to reduce inflammation and slow the progression of the disease. This may include corticosteroids or other immunosuppressive drugs. In severe cases, surgery may be necessary to remove the fibrous tissue or to bypass blocked ureters. | Treatment for retroperitoneal fibrosis typically involves medications to reduce inflammation and slow the progression of the disease. This may include corticosteroids or other immunosuppressive drugs. In severe cases, surgery may be necessary to remove the fibrous tissue or to bypass blocked ureters. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for individuals with retroperitoneal fibrosis can vary greatly depending on the severity of the disease and the individual's overall health. With appropriate treatment, many individuals can lead a normal life. However, ongoing monitoring is typically necessary to manage the condition and prevent complications. | The prognosis for individuals with retroperitoneal fibrosis can vary greatly depending on the severity of the disease and the individual's overall health. With appropriate treatment, many individuals can lead a normal life. However, ongoing monitoring is typically necessary to manage the condition and prevent complications. | ||
== See also == | == See also == | ||
* [[Peritoneum]] | * [[Peritoneum]] | ||
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* [[Computed tomography]] | * [[Computed tomography]] | ||
* [[Magnetic resonance imaging]] | * [[Magnetic resonance imaging]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Inflammatory diseases]] | [[Category:Inflammatory diseases]] | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 03:34, 4 April 2025
| Retroperitoneal fibrosis | |
|---|---|
| Synonyms | Ormond's disease |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Abdominal pain, back pain, weight loss, nausea, vomiting, hypertension, renal failure |
| Complications | Kidney failure, ureteral obstruction |
| Onset | Typically between ages 40 and 60 |
| Duration | Chronic |
| Types | N/A |
| Causes | Often idiopathic, can be secondary to medications, infections, malignancies, or autoimmune diseases |
| Risks | Smoking, male gender, genetic predisposition |
| Diagnosis | CT scan, MRI, biopsy |
| Differential diagnosis | Lymphoma, sarcoma, aortic aneurysm |
| Prevention | N/A |
| Treatment | Corticosteroids, immunosuppressive drugs, surgery |
| Medication | Prednisone, azathioprine, mycophenolate mofetil |
| Prognosis | Variable, depends on response to treatment |
| Frequency | Rare |
| Deaths | N/A |
Retroperitoneal fibrosis or Ormond's disease is a rare disorder characterized by the presence of inflammatory and fibrous tissue behind the peritoneum, the membrane that lines the abdominal cavity. This fibrous tissue often surrounds the aorta and the ureters, potentially causing abdominal pain and kidney damage.
Causes[edit]
The exact cause of retroperitoneal fibrosis is unknown. However, it is believed to be associated with certain autoimmune diseases, infections, and exposure to certain drugs or toxins. In some cases, it may be idiopathic, meaning it occurs without any identifiable cause.
Symptoms[edit]
The symptoms of retroperitoneal fibrosis can vary greatly depending on the individual and the severity of the condition. Common symptoms include:
- Abdominal pain
- Back pain
- Unintentional weight loss
- Fatigue
- Fever
- Nausea and vomiting
- Urinary symptoms such as increased frequency or urgency
Diagnosis[edit]
Diagnosis of retroperitoneal fibrosis is often challenging due to its nonspecific symptoms. It typically involves a combination of medical history, physical examination, and imaging studies such as CT or MRI. In some cases, a biopsy may be necessary to confirm the diagnosis.
Treatment[edit]
Treatment for retroperitoneal fibrosis typically involves medications to reduce inflammation and slow the progression of the disease. This may include corticosteroids or other immunosuppressive drugs. In severe cases, surgery may be necessary to remove the fibrous tissue or to bypass blocked ureters.
Prognosis[edit]
The prognosis for individuals with retroperitoneal fibrosis can vary greatly depending on the severity of the disease and the individual's overall health. With appropriate treatment, many individuals can lead a normal life. However, ongoing monitoring is typically necessary to manage the condition and prevent complications.
