Esterified estrogens

Esterified estrogens are a form of estrogen that are used in hormone therapy. They are a mixture of several different estrogens that are derived from natural sources and blended to approximate the composition of estrogens found in the urine of pregnant women. Esterified estrogens are often used in combination with methyltestosterone for the treatment of moderate to severe vasomotor symptoms associated with menopause in women who have not responded well to other therapies.

Composition

Esterified estrogens are composed of several different estrogens, including estrone, equilin, 17 alpha-dihydroequilin, 17 alpha-estradiol, and 17 beta-dihydroequilin. These estrogens are derived from natural sources and are blended to approximate the composition of estrogens found in the urine of pregnant women.

Uses

Esterified estrogens are used in hormone therapy for the treatment of moderate to severe vasomotor symptoms associated with menopause in women who have not responded well to other therapies. They are also used to treat vulvovaginal atrophy, hypoestrogenism, and certain types of breast cancer in men and women.

Side Effects

Like all medications, esterified estrogens can cause side effects. These may include nausea, vomiting, bloating, stomach cramps, breast pain, swelling, weight changes, darkening of the skin or freckles, loss of scalp hair, vaginal itching or discharge, changes in menstrual periods, decreased sex drive, migraine headaches, dizziness, depression, and changes in the shape or location of body fat.

Precautions

Before taking esterified estrogens, it is important to discuss any medical conditions or allergies with a healthcare provider. This medication should not be used during pregnancy or while breastfeeding. It may also increase the risk of certain types of cancer, including breast cancer and endometrial cancer, and should be used with caution in women with a history of these conditions.

Interactions

Esterified estrogens can interact with other medications, including certain antibiotics, antifungal medications, HIV/AIDS medications, seizure medications, and thyroid medications. It is important to discuss all medications and supplements with a healthcare provider before starting treatment with esterified estrogens.

See Also

• Estrogen
• Hormone therapy
• Menopause
• Breast cancer
• Endometrial cancer

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