HHV-8-associated MCD: Difference between revisions
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{{SI}} {{Infobox medical condition | |||
| name = HHV-8-associated Multicentric Castleman Disease | |||
| image = [[File:BX2306-20-12043-01-HHV8-06@40x_(Enfermedad_de_Castleman_multicéntrica_asociada_a_HHV8_y_sarcoma_de_Kaposi).jpg|250px]] | |||
| caption = Histopathological image of HHV-8-associated Multicentric Castleman Disease | |||
| synonyms = [[Kaposi sarcoma-associated herpesvirus]]-associated Multicentric Castleman Disease | |||
| field = [[Hematology]] | |||
| symptoms = [[Lymphadenopathy]], [[fever]], [[night sweats]], [[weight loss]], [[fatigue]] | |||
| complications = [[Kaposi's sarcoma]], [[lymphoma]], [[organ failure]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = Chronic | |||
| causes = Infection with [[Human herpesvirus 8]] (HHV-8) | |||
| risks = [[Immunosuppression]], [[HIV/AIDS]] | |||
| diagnosis = [[Biopsy]], [[immunohistochemistry]], [[PCR]] for HHV-8 | |||
| differential = [[Lymphoma]], [[HIV-associated multicentric Castleman disease]], [[autoimmune disorders]] | |||
| treatment = [[Antiviral therapy]], [[chemotherapy]], [[immunotherapy]] | |||
| prognosis = Variable, depends on response to treatment | |||
| frequency = Rare | |||
| deaths = Can be fatal if untreated | |||
}} | |||
[[File:Kaposi sarcoma in a patient with HHV8-associated MCD.jpg|HHV-8-associated MCD|thumb|left]] | |||
'''HHV-8-associated MCD''' is a rare, non-cancerous [[lymphoproliferative disorder]] that is associated with the [[Human herpesvirus 8|Human Herpesvirus 8]] (HHV-8). This condition is characterized by the overgrowth of [[lymphocytes]], a type of white blood cell, in the [[lymph nodes]]. | '''HHV-8-associated MCD''' is a rare, non-cancerous [[lymphoproliferative disorder]] that is associated with the [[Human herpesvirus 8|Human Herpesvirus 8]] (HHV-8). This condition is characterized by the overgrowth of [[lymphocytes]], a type of white blood cell, in the [[lymph nodes]]. | ||
==Symptoms== | ==Symptoms== | ||
The symptoms of HHV-8-associated MCD can vary widely, but often include [[fever]], [[night sweats]], [[weight loss]], and [[fatigue]]. Some patients may also experience [[abdominal pain]], [[nausea]], and [[vomiting]] due to enlargement of the [[spleen]] or [[liver]]. | The symptoms of HHV-8-associated MCD can vary widely, but often include [[fever]], [[night sweats]], [[weight loss]], and [[fatigue]]. Some patients may also experience [[abdominal pain]], [[nausea]], and [[vomiting]] due to enlargement of the [[spleen]] or [[liver]]. | ||
==Causes== | ==Causes== | ||
HHV-8-associated MCD is caused by an infection with the Human Herpesvirus 8. This virus is also known to cause [[Kaposi's sarcoma]], a type of cancer that can affect the skin, mouth, and internal organs. | HHV-8-associated MCD is caused by an infection with the Human Herpesvirus 8. This virus is also known to cause [[Kaposi's sarcoma]], a type of cancer that can affect the skin, mouth, and internal organs. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of HHV-8-associated MCD is typically made through a combination of [[physical examination]], [[blood tests]], and [[imaging studies]]. In some cases, a [[biopsy]] of the affected lymph node may be necessary to confirm the diagnosis. | The diagnosis of HHV-8-associated MCD is typically made through a combination of [[physical examination]], [[blood tests]], and [[imaging studies]]. In some cases, a [[biopsy]] of the affected lymph node may be necessary to confirm the diagnosis. | ||
==Treatment== | ==Treatment== | ||
The treatment of HHV-8-associated MCD typically involves the use of [[antiviral medications]] to control the HHV-8 infection, as well as [[immunomodulatory drugs]] to reduce the overgrowth of lymphocytes. In severe cases, [[chemotherapy]] may be necessary. | The treatment of HHV-8-associated MCD typically involves the use of [[antiviral medications]] to control the HHV-8 infection, as well as [[immunomodulatory drugs]] to reduce the overgrowth of lymphocytes. In severe cases, [[chemotherapy]] may be necessary. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for patients with HHV-8-associated MCD can vary widely, depending on the severity of the disease and the patient's overall health. However, with appropriate treatment, many patients can achieve a good quality of life. | The prognosis for patients with HHV-8-associated MCD can vary widely, depending on the severity of the disease and the patient's overall health. However, with appropriate treatment, many patients can achieve a good quality of life. | ||
==See also== | ==See also== | ||
* [[Human herpesvirus 8]] | * [[Human herpesvirus 8]] | ||
* [[Lymphoproliferative disorders]] | * [[Lymphoproliferative disorders]] | ||
* [[Kaposi's sarcoma]] | * [[Kaposi's sarcoma]] | ||
[[Category:Medical conditions]] | [[Category:Medical conditions]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Viral diseases]] | [[Category:Viral diseases]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 04:04, 9 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| HHV-8-associated Multicentric Castleman Disease | |
|---|---|
.jpg)
| |
| Synonyms | Kaposi sarcoma-associated herpesvirus-associated Multicentric Castleman Disease |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Lymphadenopathy, fever, night sweats, weight loss, fatigue |
| Complications | Kaposi's sarcoma, lymphoma, organ failure |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | N/A |
| Causes | Infection with Human herpesvirus 8 (HHV-8) |
| Risks | Immunosuppression, HIV/AIDS |
| Diagnosis | Biopsy, immunohistochemistry, PCR for HHV-8 |
| Differential diagnosis | Lymphoma, HIV-associated multicentric Castleman disease, autoimmune disorders |
| Prevention | N/A |
| Treatment | Antiviral therapy, chemotherapy, immunotherapy |
| Medication | N/A |
| Prognosis | Variable, depends on response to treatment |
| Frequency | Rare |
| Deaths | Can be fatal if untreated |
HHV-8-associated MCD is a rare, non-cancerous lymphoproliferative disorder that is associated with the Human Herpesvirus 8 (HHV-8). This condition is characterized by the overgrowth of lymphocytes, a type of white blood cell, in the lymph nodes.
Symptoms[edit]
The symptoms of HHV-8-associated MCD can vary widely, but often include fever, night sweats, weight loss, and fatigue. Some patients may also experience abdominal pain, nausea, and vomiting due to enlargement of the spleen or liver.
Causes[edit]
HHV-8-associated MCD is caused by an infection with the Human Herpesvirus 8. This virus is also known to cause Kaposi's sarcoma, a type of cancer that can affect the skin, mouth, and internal organs.
Diagnosis[edit]
The diagnosis of HHV-8-associated MCD is typically made through a combination of physical examination, blood tests, and imaging studies. In some cases, a biopsy of the affected lymph node may be necessary to confirm the diagnosis.
Treatment[edit]
The treatment of HHV-8-associated MCD typically involves the use of antiviral medications to control the HHV-8 infection, as well as immunomodulatory drugs to reduce the overgrowth of lymphocytes. In severe cases, chemotherapy may be necessary.
Prognosis[edit]
The prognosis for patients with HHV-8-associated MCD can vary widely, depending on the severity of the disease and the patient's overall health. However, with appropriate treatment, many patients can achieve a good quality of life.
