Taxoid: Difference between revisions

Latest revision as of 19:17, 22 March 2025

Taxoids are a class of diterpenes that are derived from the yew tree, particularly from the genus Taxus. These compounds are notable for their complex structure and significant anticancer properties. The most famous taxoid is paclitaxel, commonly known by its brand name Taxol.

Structure[edit]

Taxoids are characterized by their taxane core, a complex polycyclic structure that includes an oxetane ring. The taxane core is a tricyclic 15-carbon skeleton, which is often modified with various functional groups that contribute to the biological activity of these compounds.

Biosynthesis[edit]

Taxoids are biosynthesized in the bark and needles of yew trees. The biosynthetic pathway involves the conversion of geranylgeranyl pyrophosphate (GGPP) to the taxane core through a series of enzymatic reactions. Key enzymes in this pathway include taxadiene synthase and taxadiene 5α-hydroxylase.

Pharmacology[edit]

Taxoids, particularly paclitaxel, exert their anticancer effects by stabilizing microtubules and preventing their depolymerization. This action disrupts the normal function of the mitotic spindle, thereby inhibiting cell division and inducing apoptosis in rapidly dividing cancer cells.

Clinical Use[edit]

Paclitaxel is used in the treatment of various types of cancer, including ovarian cancer, breast cancer, lung cancer, and Kaposi's sarcoma. It is often administered in combination with other chemotherapeutic agents to enhance its efficacy.

Derivatives[edit]

Several derivatives of paclitaxel have been developed to improve its solubility and reduce side effects. Notable derivatives include docetaxel and cabazitaxel, which have been used in the treatment of prostate cancer and other malignancies.

Challenges in Production[edit]

The extraction of taxoids from natural sources is challenging due to the low yield and slow growth of yew trees. As a result, semisynthetic and synthetic methods have been developed to produce these compounds more efficiently. The development of plant cell culture techniques has also been explored to increase the production of taxoids.

Related pages[edit]

@@ Line 1: / Line 1: @@
-{{Distinguish|Toxoid}}
+{{Taxobox
+| name = Taxoid
+| image = Taxol.svg
+| image_caption = Structure of Paclitaxel, a well-known taxoid
+}}
-'''Taxoid'''s are a class of derivatives from taxol,<ref>{{Cite web|url=http://www.usrf.org/news/19MAY04taxotere/Sci%20Am%20Taxoids%201996.pdf |title=Taxoids: New Weapons against Cancer |year=1996 }}</ref> that is, [[paclitaxel]]. They were developed for their anticancer [[chemotherapy|chemotherapeutic]] properties. Taxoids are usually treated as [[synonym]]ous with [[taxane]]s; for example, a major medical dictionary defines the two terms with the same definition phrasing,<ref name="Dorlands">{{Citation |author=Elsevier |authorlink=Elsevier |title=Dorland's Illustrated Medical Dictionary |publisher=Elsevier |url=http://dorlands.com/ |postscript=.}}</ref> and in another the phrasing varies slightly but conveys nearly identical meaning.<ref name="Stedmans">{{Citation |author=Wolters Kluwer |authorlink=Wolters Kluwer |title=Stedman's Medical Dictionary |publisher=Wolters Kluwer |url=http://stedmansonline.com/ |postscript=.}}</ref> The taxoids class and the taxanes class both include [[paclitaxel]] (trade names Taxol, Abraxane, Onxol, Nov-Onxol) and [[docetaxel]] (trade names Taxotere, Docecad).
+'''Taxoids''' are a class of [[diterpenes]] that are derived from the [[yew]] tree, particularly from the genus ''[[Taxus]]''. These compounds are notable for their complex structure and significant [[anticancer]] properties. The most famous taxoid is [[paclitaxel]], commonly known by its brand name [[Taxol]].
-==References==
+==Structure==
-{{Reflist}}
+Taxoids are characterized by their [[taxane]] core, a complex polycyclic structure that includes an [[oxetane]] ring. The taxane core is a [[tricyclic]] 15-carbon skeleton, which is often modified with various functional groups that contribute to the biological activity of these compounds.
-[[Category:Mitotic inhibitors]]
+==Biosynthesis==
+Taxoids are biosynthesized in the [[bark]] and [[needles]] of yew trees. The biosynthetic pathway involves the conversion of [[geranylgeranyl pyrophosphate]] (GGPP) to the taxane core through a series of enzymatic reactions. Key enzymes in this pathway include [[taxadiene synthase]] and [[taxadiene 5α-hydroxylase]].
+==Pharmacology==
+Taxoids, particularly paclitaxel, exert their [[anticancer]] effects by stabilizing [[microtubules]] and preventing their depolymerization. This action disrupts the normal function of the [[mitotic spindle]], thereby inhibiting [[cell division]] and inducing [[apoptosis]] in rapidly dividing [[cancer cells]].
-{{antineoplastic-drug-stub}}
+==Clinical Use==
-{{dictionary-stub1}}
+Paclitaxel is used in the treatment of various types of [[cancer]], including [[ovarian cancer]], [[breast cancer]], [[lung cancer]], and [[Kaposi's sarcoma]]. It is often administered in combination with other [[chemotherapeutic agents]] to enhance its efficacy.
+==Derivatives==
+Several derivatives of paclitaxel have been developed to improve its solubility and reduce side effects. Notable derivatives include [[docetaxel]] and [[cabazitaxel]], which have been used in the treatment of [[prostate cancer]] and other malignancies.
+==Challenges in Production==
+The extraction of taxoids from natural sources is challenging due to the low yield and slow growth of yew trees. As a result, [[semisynthetic]] and [[synthetic]] methods have been developed to produce these compounds more efficiently. The development of [[plant cell culture]] techniques has also been explored to increase the production of taxoids.
+==Related pages==
+* [[Paclitaxel]]
+* [[Docetaxel]]
+* [[Anticancer drugs]]
+* [[Microtubule]]
+[[Category:Diterpenes]]
+[[Category:Anticancer drugs]]
+[[Category:Taxanes]]