Acinic cell carcinoma: Difference between revisions
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{{Infobox medical condition | |||
{{Infobox medical condition | |||
| name = Acinic cell carcinoma | | name = Acinic cell carcinoma | ||
| image =[[File:Acinic_cell_carcinoma_-_high_mag.jpg|alt=Micrograph of acinic cell carcinoma]] | |||
| image = | | caption = Micrograph of acinic cell carcinoma | ||
| caption = [[ | | field = [[Oncology]] | ||
| | | synonyms = Acinic cell adenocarcinoma | ||
| symptoms = [[Swelling]] in the [[parotid gland]], [[pain]] | |||
| complications = [[Facial nerve]] dysfunction | |||
| onset = Typically in [[adulthood]] | |||
| onset = | | duration = Long-term | ||
| duration = | | types = [[Papillary cystic]], [[follicular]], [[solid]], [[microcystic]] | ||
| types = | | causes = Unknown | ||
| causes = | | risks = [[Radiation exposure]], [[genetic predisposition]] | ||
| risks = | | diagnosis = [[Biopsy]], [[imaging studies]] | ||
| diagnosis = | | differential = [[Pleomorphic adenoma]], [[mucoepidermoid carcinoma]] | ||
| differential = | | prevention = None known | ||
| prevention = | | treatment = [[Surgery]], [[radiation therapy]] | ||
| treatment = | | medication = None specific | ||
| medication = | | prognosis = Generally good with treatment | ||
| prognosis = | | frequency = Rare | ||
| frequency = | |||
}} | }} | ||
{{Short description|A type of salivary gland cancer}} | |||
{{Medical resources}} | |||
'''Acinic cell carcinoma''' is a rare type of [[salivary gland]] [[cancer]] that primarily affects the [[parotid gland]], which is the largest of the salivary glands located near the ear. This type of carcinoma is characterized by its slow growth and relatively low potential for metastasis compared to other salivary gland cancers. | |||
Acinic cell | ==Pathophysiology== | ||
Acinic cell carcinoma arises from the [[acinar cells]] of the salivary glands, which are responsible for producing [[saliva]]. These tumors are typically composed of cells that resemble normal acinar cells, and they can exhibit a variety of growth patterns, including solid, microcystic, papillary-cystic, and follicular. | |||
The [[histology]] of acinic cell carcinoma is notable for its diversity, with tumor cells often showing granular cytoplasm due to the presence of [[zymogen granules]]. This feature can help distinguish acinic cell carcinoma from other types of salivary gland tumors. | |||
== | ==Clinical Presentation== | ||
Patients with acinic cell carcinoma often present with a painless, slow-growing mass in the region of the parotid gland. In some cases, the tumor may cause facial nerve dysfunction if it invades nearby structures. Other symptoms can include swelling, discomfort, or a feeling of fullness in the affected area. | |||
The | ==Diagnosis== | ||
The diagnosis of acinic cell carcinoma typically involves a combination of clinical evaluation, imaging studies, and [[biopsy]]. Imaging techniques such as [[ultrasound]], [[CT scan]], or [[MRI]] can help assess the extent of the tumor and its relationship to surrounding structures. A definitive diagnosis is made through histopathological examination of a biopsy specimen. | |||
==Treatment== | ==Treatment== | ||
The primary treatment for acinic cell carcinoma is surgical resection, often involving a [[parotidectomy]] to remove the affected gland. The extent of surgery depends on the size and location of the tumor, as well as its proximity to critical structures such as the facial nerve. | |||
In some cases, [[radiation therapy]] may be recommended postoperatively, especially if there are concerns about residual disease or if the tumor exhibits aggressive features. [[Chemotherapy]] is generally not a primary treatment modality for acinic cell carcinoma but may be considered in cases of metastatic disease. | |||
== | ==Prognosis== | ||
The prognosis for patients with acinic cell carcinoma is generally favorable, with a high rate of long-term survival. However, the risk of recurrence and metastasis, although lower than in other salivary gland cancers, still exists. Factors influencing prognosis include tumor size, histological grade, and the presence of perineural invasion. | |||
== | ==Related Pages== | ||
* [[Salivary gland tumors]] | |||
* [[Parotid gland]] | |||
* [[Histopathology]] | |||
* [[Oncology]] | |||
* | |||
* | |||
* | |||
[[Category:Salivary gland neoplasia]] | [[Category:Salivary gland neoplasia]] | ||
[[Category:Head and neck cancer]] | |||
Latest revision as of 03:12, 4 April 2025
| Acinic cell carcinoma | |
|---|---|
| |
| Synonyms | Acinic cell adenocarcinoma |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Swelling in the parotid gland, pain |
| Complications | Facial nerve dysfunction |
| Onset | Typically in adulthood |
| Duration | Long-term |
| Types | Papillary cystic, follicular, solid, microcystic |
| Causes | Unknown |
| Risks | Radiation exposure, genetic predisposition |
| Diagnosis | Biopsy, imaging studies |
| Differential diagnosis | Pleomorphic adenoma, mucoepidermoid carcinoma |
| Prevention | None known |
| Treatment | Surgery, radiation therapy |
| Medication | None specific |
| Prognosis | Generally good with treatment |
| Frequency | Rare |
| Deaths | N/A |
A type of salivary gland cancer
Acinic cell carcinoma is a rare type of salivary gland cancer that primarily affects the parotid gland, which is the largest of the salivary glands located near the ear. This type of carcinoma is characterized by its slow growth and relatively low potential for metastasis compared to other salivary gland cancers.
Pathophysiology[edit]
Acinic cell carcinoma arises from the acinar cells of the salivary glands, which are responsible for producing saliva. These tumors are typically composed of cells that resemble normal acinar cells, and they can exhibit a variety of growth patterns, including solid, microcystic, papillary-cystic, and follicular.
The histology of acinic cell carcinoma is notable for its diversity, with tumor cells often showing granular cytoplasm due to the presence of zymogen granules. This feature can help distinguish acinic cell carcinoma from other types of salivary gland tumors.
Clinical Presentation[edit]
Patients with acinic cell carcinoma often present with a painless, slow-growing mass in the region of the parotid gland. In some cases, the tumor may cause facial nerve dysfunction if it invades nearby structures. Other symptoms can include swelling, discomfort, or a feeling of fullness in the affected area.
Diagnosis[edit]
The diagnosis of acinic cell carcinoma typically involves a combination of clinical evaluation, imaging studies, and biopsy. Imaging techniques such as ultrasound, CT scan, or MRI can help assess the extent of the tumor and its relationship to surrounding structures. A definitive diagnosis is made through histopathological examination of a biopsy specimen.
Treatment[edit]
The primary treatment for acinic cell carcinoma is surgical resection, often involving a parotidectomy to remove the affected gland. The extent of surgery depends on the size and location of the tumor, as well as its proximity to critical structures such as the facial nerve.
In some cases, radiation therapy may be recommended postoperatively, especially if there are concerns about residual disease or if the tumor exhibits aggressive features. Chemotherapy is generally not a primary treatment modality for acinic cell carcinoma but may be considered in cases of metastatic disease.
Prognosis[edit]
The prognosis for patients with acinic cell carcinoma is generally favorable, with a high rate of long-term survival. However, the risk of recurrence and metastasis, although lower than in other salivary gland cancers, still exists. Factors influencing prognosis include tumor size, histological grade, and the presence of perineural invasion.
