S1PR3: Difference between revisions

Latest revision as of 12:40, 31 December 2024

Sphingosine-1-phosphate receptor 3 (S1PR3) is a G protein-coupled receptor that binds the bioactive lipid sphingosine-1-phosphate (S1P). It is part of the sphingosine-1-phosphate receptor family, which plays a crucial role in various physiological processes.

Structure[edit]

S1PR3 is a member of the G protein-coupled receptor (GPCR) superfamily, characterized by seven transmembrane domains. The receptor is encoded by the S1PR3 gene located on chromosome 9q22.1. The protein structure allows it to interact with sphingosine-1-phosphate, a signaling molecule involved in numerous cellular functions.

Function[edit]

S1PR3 is involved in the regulation of several physiological processes, including:

The receptor mediates its effects through coupling with different G proteins, leading to the activation of various downstream signaling pathways.

Expression[edit]

S1PR3 is expressed in a variety of tissues, including the endothelial cells of blood vessels, smooth muscle cells, and immune cells. Its expression pattern suggests a role in both vascular and immune system functions.

Clinical Significance[edit]

Alterations in S1PR3 signaling have been implicated in several pathological conditions, such as:

Research is ongoing to develop therapeutic agents targeting S1PR3 for the treatment of these conditions.

External Links[edit]

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-== S1PR3 ==
+{{Infobox protein
+| name = Sphingosine-1-phosphate receptor 3
+| image =
+| caption =
+| width =
+| HGNCid = 10631
+| symbol = S1PR3
+| alt_symbols = EDG-3
+| EntrezGene = 1903
+| OMIM = 601974
+| RefSeq = NM_005226
+| UniProt = Q99500
+| PDB =
+| ECnumber =
+| chromosomal_location = 9q22.1
+}}
-The S1PR3, also known as the Sphingosine-1-phosphate receptor 3, is a G protein-coupled receptor that plays a crucial role in various physiological processes. It is a member of the S1P receptor family and is primarily expressed in the cardiovascular and immune systems.
+'''Sphingosine-1-phosphate receptor 3''' ('''S1PR3''') is a [[G protein-coupled receptor]] that binds the [[bioactive lipid]] [[sphingosine-1-phosphate]] (S1P). It is part of the [[sphingosine-1-phosphate receptor]] family, which plays a crucial role in various physiological processes.
-=== Structure ===
+==Structure==
+S1PR3 is a member of the [[G protein-coupled receptor]] (GPCR) superfamily, characterized by seven transmembrane domains. The receptor is encoded by the '''S1PR3''' gene located on chromosome 9q22.1. The protein structure allows it to interact with [[sphingosine-1-phosphate]], a signaling molecule involved in numerous cellular functions.
-The S1PR3 receptor is encoded by the S1PR3 gene located on chromosome 12q13.13 in humans. It consists of 7 transmembrane domains and an extracellular N-terminus. The intracellular C-terminus is responsible for coupling with G proteins, which initiates downstream signaling pathways upon ligand binding.
+==Function==
+S1PR3 is involved in the regulation of several physiological processes, including:
-=== Function ===
+* [[Vascular development]] and [[angiogenesis]]
+* [[Immune cell trafficking]]
+* [[Cardiovascular function]]
+* [[Inflammatory response]]
-The S1PR3 receptor is activated by the lipid signaling molecule sphingosine-1-phosphate (S1P). Upon binding of S1P, the receptor undergoes conformational changes, leading to the activation of G proteins. This activation triggers a cascade of intracellular signaling events, including the activation of various kinases and the modulation of ion channels.
+The receptor mediates its effects through coupling with different [[G proteins]], leading to the activation of various downstream signaling pathways.
-The S1PR3 receptor is involved in the regulation of vascular tone, immune cell trafficking, and lymphocyte development. In the cardiovascular system, activation of S1PR3 leads to vasodilation and the inhibition of smooth muscle cell proliferation. In the immune system, it plays a role in the migration of immune cells, such as lymphocytes, to lymphoid organs and inflammatory sites.
+==Expression==
+S1PR3 is expressed in a variety of tissues, including the [[endothelial cells]] of blood vessels, [[smooth muscle cells]], and [[immune cells]]. Its expression pattern suggests a role in both vascular and immune system functions.
-=== Clinical Significance ===
+==Clinical Significance==
+Alterations in S1PR3 signaling have been implicated in several pathological conditions, such as:
-Due to its involvement in various physiological processes, dysregulation of the S1PR3 receptor has been implicated in several diseases. For example, aberrant S1PR3 signaling has been associated with cardiovascular diseases, including hypertension and atherosclerosis. In addition, it has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, due to its role in immune cell trafficking.
+* [[Atherosclerosis]]
+* [[Hypertension]]
+* [[Autoimmune diseases]]
+* [[Cancer]]
-Pharmaceutical companies have recognized the therapeutic potential of targeting the S1PR3 receptor. Selective modulators of S1PR3 are being developed as potential treatments for cardiovascular diseases and autoimmune disorders. These modulators aim to either activate or inhibit the receptor, depending on the specific disease and desired therapeutic outcome.
+Research is ongoing to develop therapeutic agents targeting S1PR3 for the treatment of these conditions.
-=== References ===
+==See Also==
+* [[Sphingosine-1-phosphate receptor]]
+* [[G protein-coupled receptor]]
+* [[Bioactive lipid]]
-<references>
+==External Links==
-  <ref>Example Reference 1</ref>
+* [https://www.wikimd.com/wiki/S1PR3 S1PR3 on WikiMD]
-  <ref>Example Reference 2</ref>
+* [https://www.ncbi.nlm.nih.gov/gene/1903 S1PR3 Gene - NCBI]
-</references>
-== See Also ==
+{{G protein-coupled receptors}}
+{{Sphingolipids}}
-* [[Sphingosine-1-phosphate receptor]]
-* [[G protein-coupled receptor]]
-* [[Cardiovascular system]]
-* [[Immune system]]
+[[Category:Receptors]]
 [[Category:G protein-coupled receptors]]
-[[Category:Cardiovascular system]]
+[[Category:Human proteins]]
-[[Category:Immune system]]
+[[Category:Chromosome 9 genes]]
-[[Category:Cell signaling]]
-[[Category:Pharmacology]]
-[[Category:Biological receptors]]