Intermediate uveitis: Difference between revisions
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{{Infobox medical condition | |||
[[File:Anterior_vitreous_cells.jpg| | | name = Intermediate uveitis | ||
| image = [[File:Anterior_vitreous_cells.jpg|250px]] | |||
| caption = Anterior vitreous cells seen in intermediate uveitis | |||
| field = [[Ophthalmology]] | |||
| synonyms = Pars planitis, peripheral uveitis | |||
| symptoms = [[Floaters]], [[blurred vision]], [[photophobia (medicine)|photophobia]] | |||
| complications = [[Cystoid macular edema]], [[cataract]], [[glaucoma]] | |||
| onset = Typically in young adults | |||
| duration = Chronic | |||
| types = | |||
| causes = Often idiopathic, can be associated with [[multiple sclerosis]], [[sarcoidosis]], [[Lyme disease]] | |||
| risks = | |||
| diagnosis = [[Ophthalmoscopy]], [[fluorescein angiography]], [[optical coherence tomography]] | |||
| differential = [[Posterior uveitis]], [[anterior uveitis]], [[retinal detachment]] | |||
| prevention = | |||
| treatment = [[Corticosteroids]], [[immunosuppressive drug|immunosuppressive therapy]], [[cryotherapy]], [[vitrectomy]] | |||
| medication = [[Corticosteroids]], [[methotrexate]], [[infliximab]] | |||
| prognosis = Variable, can lead to vision loss if untreated | |||
| frequency = Rare | |||
| deaths = | |||
}} | |||
'''Intermediate uveitis''' is a form of [[uveitis]] that primarily affects the [[vitreous body]] and the peripheral [[retina]]. It is characterized by inflammation of the [[pars plana]], the area between the [[ciliary body]] and the [[retina]]. This condition is also known as "pars planitis" when it occurs without an associated systemic disease. | '''Intermediate uveitis''' is a form of [[uveitis]] that primarily affects the [[vitreous body]] and the peripheral [[retina]]. It is characterized by inflammation of the [[pars plana]], the area between the [[ciliary body]] and the [[retina]]. This condition is also known as "pars planitis" when it occurs without an associated systemic disease. | ||
== Clinical Features == | == Clinical Features == | ||
Intermediate uveitis typically presents with floaters and blurred vision. Patients may also experience mild discomfort or redness in the affected eye. The hallmark of intermediate uveitis is the presence of inflammatory cells in the [[vitreous humor]], which can be observed during an eye examination. | Intermediate uveitis typically presents with floaters and blurred vision. Patients may also experience mild discomfort or redness in the affected eye. The hallmark of intermediate uveitis is the presence of inflammatory cells in the [[vitreous humor]], which can be observed during an eye examination. | ||
=== Symptoms === | === Symptoms === | ||
* Floaters | * Floaters | ||
* Blurred vision | * Blurred vision | ||
* Mild eye discomfort | * Mild eye discomfort | ||
* Redness of the eye | * Redness of the eye | ||
=== Signs === | === Signs === | ||
* Vitreous cells and haze | * Vitreous cells and haze | ||
* Snowbanking or snowballs in the peripheral retina | * Snowbanking or snowballs in the peripheral retina | ||
* Possible cystoid macular edema | * Possible cystoid macular edema | ||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of intermediate uveitis is primarily clinical, based on the presence of vitreous cells and the exclusion of other causes of uveitis. Ancillary tests such as [[fluorescein angiography]] and [[optical coherence tomography]] (OCT) may be used to assess the extent of retinal involvement and macular edema. | The diagnosis of intermediate uveitis is primarily clinical, based on the presence of vitreous cells and the exclusion of other causes of uveitis. Ancillary tests such as [[fluorescein angiography]] and [[optical coherence tomography]] (OCT) may be used to assess the extent of retinal involvement and macular edema. | ||
== Etiology == | == Etiology == | ||
Intermediate uveitis can be idiopathic or associated with systemic diseases such as [[multiple sclerosis]], [[sarcoidosis]], or [[Lyme disease]]. It is important to evaluate patients for these conditions, especially if the uveitis is bilateral or recurrent. | Intermediate uveitis can be idiopathic or associated with systemic diseases such as [[multiple sclerosis]], [[sarcoidosis]], or [[Lyme disease]]. It is important to evaluate patients for these conditions, especially if the uveitis is bilateral or recurrent. | ||
== Treatment == | == Treatment == | ||
The treatment of intermediate uveitis aims to reduce inflammation and prevent complications. Corticosteroids are the mainstay of therapy, administered either topically, orally, or via periocular injections. In cases where corticosteroids are insufficient or contraindicated, immunosuppressive agents such as [[methotrexate]] or [[azathioprine]] may be used. | The treatment of intermediate uveitis aims to reduce inflammation and prevent complications. Corticosteroids are the mainstay of therapy, administered either topically, orally, or via periocular injections. In cases where corticosteroids are insufficient or contraindicated, immunosuppressive agents such as [[methotrexate]] or [[azathioprine]] may be used. | ||
=== Corticosteroids === | === Corticosteroids === | ||
* Topical corticosteroids for mild cases | * Topical corticosteroids for mild cases | ||
* Oral corticosteroids for more severe inflammation | * Oral corticosteroids for more severe inflammation | ||
* Periocular injections for localized treatment | * Periocular injections for localized treatment | ||
=== Immunosuppressive Therapy === | === Immunosuppressive Therapy === | ||
* Methotrexate | * Methotrexate | ||
* Azathioprine | * Azathioprine | ||
* Biologic agents in refractory cases | * Biologic agents in refractory cases | ||
== Prognosis == | == Prognosis == | ||
The prognosis for intermediate uveitis varies depending on the underlying cause and the response to treatment. With appropriate management, many patients can achieve good visual outcomes. However, complications such as [[cataract]], [[glaucoma]], and [[macular edema]] can affect the prognosis. | The prognosis for intermediate uveitis varies depending on the underlying cause and the response to treatment. With appropriate management, many patients can achieve good visual outcomes. However, complications such as [[cataract]], [[glaucoma]], and [[macular edema]] can affect the prognosis. | ||
== See Also == | |||
== | |||
* [[Uveitis]] | * [[Uveitis]] | ||
* [[Vitreous body]] | * [[Vitreous body]] | ||
* [[Retina]] | * [[Retina]] | ||
* [[Ciliary body]] | * [[Ciliary body]] | ||
{{Uveitis}} | {{Uveitis}} | ||
[[Category:Ophthalmology]] | [[Category:Ophthalmology]] | ||
[[Category:Inflammatory diseases of the eye]] | [[Category:Inflammatory diseases of the eye]] | ||
Latest revision as of 03:42, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Intermediate uveitis | |
|---|---|
| |
| Synonyms | Pars planitis, peripheral uveitis |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Floaters, blurred vision, photophobia |
| Complications | Cystoid macular edema, cataract, glaucoma |
| Onset | Typically in young adults |
| Duration | Chronic |
| Types | |
| Causes | Often idiopathic, can be associated with multiple sclerosis, sarcoidosis, Lyme disease |
| Risks | |
| Diagnosis | Ophthalmoscopy, fluorescein angiography, optical coherence tomography |
| Differential diagnosis | Posterior uveitis, anterior uveitis, retinal detachment |
| Prevention | |
| Treatment | Corticosteroids, immunosuppressive therapy, cryotherapy, vitrectomy |
| Medication | Corticosteroids, methotrexate, infliximab |
| Prognosis | Variable, can lead to vision loss if untreated |
| Frequency | Rare |
| Deaths | |
Intermediate uveitis is a form of uveitis that primarily affects the vitreous body and the peripheral retina. It is characterized by inflammation of the pars plana, the area between the ciliary body and the retina. This condition is also known as "pars planitis" when it occurs without an associated systemic disease.
Clinical Features[edit]
Intermediate uveitis typically presents with floaters and blurred vision. Patients may also experience mild discomfort or redness in the affected eye. The hallmark of intermediate uveitis is the presence of inflammatory cells in the vitreous humor, which can be observed during an eye examination.
Symptoms[edit]
- Floaters
- Blurred vision
- Mild eye discomfort
- Redness of the eye
Signs[edit]
- Vitreous cells and haze
- Snowbanking or snowballs in the peripheral retina
- Possible cystoid macular edema
Diagnosis[edit]
The diagnosis of intermediate uveitis is primarily clinical, based on the presence of vitreous cells and the exclusion of other causes of uveitis. Ancillary tests such as fluorescein angiography and optical coherence tomography (OCT) may be used to assess the extent of retinal involvement and macular edema.
Etiology[edit]
Intermediate uveitis can be idiopathic or associated with systemic diseases such as multiple sclerosis, sarcoidosis, or Lyme disease. It is important to evaluate patients for these conditions, especially if the uveitis is bilateral or recurrent.
Treatment[edit]
The treatment of intermediate uveitis aims to reduce inflammation and prevent complications. Corticosteroids are the mainstay of therapy, administered either topically, orally, or via periocular injections. In cases where corticosteroids are insufficient or contraindicated, immunosuppressive agents such as methotrexate or azathioprine may be used.
Corticosteroids[edit]
- Topical corticosteroids for mild cases
- Oral corticosteroids for more severe inflammation
- Periocular injections for localized treatment
Immunosuppressive Therapy[edit]
- Methotrexate
- Azathioprine
- Biologic agents in refractory cases
Prognosis[edit]
The prognosis for intermediate uveitis varies depending on the underlying cause and the response to treatment. With appropriate management, many patients can achieve good visual outcomes. However, complications such as cataract, glaucoma, and macular edema can affect the prognosis.
