Histiocytosis: Difference between revisions
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'''Histiocytosis''' is a general name for a group of syndromes that involve an abnormal increase in the number of [[immune cells]] known as [[histiocytes]]. The disease can affect anyone from infants to older adults. | {{SI}} {{Infobox medical condition | ||
| name = Histiocytosis | |||
| image = [[File:Sinus_histiocytosis_(intermediate_magnification).jpg|alt=Micrograph of sinus histiocytosis]] | |||
| caption = Micrograph of sinus histiocytosis | |||
| field = [[Hematology]] | |||
| symptoms = Varies by type; may include [[fever]], [[weight loss]], [[skin rash]], [[bone pain]] | |||
| complications = [[Organ dysfunction]], [[bone lesions]], [[diabetes insipidus]] | |||
| onset = Usually in [[childhood]] | |||
| duration = Varies | |||
| types = [[Langerhans cell histiocytosis]], [[Hemophagocytic lymphohistiocytosis]], [[Rosai-Dorfman disease]] | |||
| causes = Abnormal proliferation of [[histiocytes]] | |||
| risks = Genetic factors, [[immune system]] dysregulation | |||
| diagnosis = [[Biopsy]], [[imaging studies]], [[blood tests]] | |||
| differential = [[Infection]], [[malignancy]], [[autoimmune disease]] | |||
| treatment = [[Chemotherapy]], [[radiation therapy]], [[immunotherapy]], [[surgery]] | |||
| prognosis = Varies by type and severity | |||
| frequency = Rare | |||
}} | |||
[[Category:Histiocytosis]] | |||
[[Category:Rare diseases]] | |||
[[Category:Hematology]]'''Histiocytosis''' is a general name for a group of syndromes that involve an abnormal increase in the number of [[immune cells]] known as [[histiocytes]]. The disease can affect anyone from infants to older adults. | |||
==Types of Histiocytosis== | ==Types of Histiocytosis== | ||
There are several types of histiocytosis, including: | There are several types of histiocytosis, including: | ||
* '''[[Langerhans cell histiocytosis]] (LCH)''': This is the most common type of histiocytosis. LCH can damage skin, bones, and other parts of the body, or form tumors. | * '''[[Langerhans cell histiocytosis]] (LCH)''': This is the most common type of histiocytosis. LCH can damage skin, bones, and other parts of the body, or form tumors. | ||
* '''[[Non-Langerhans cell histiocytosis]]''': This type includes a variety of conditions that cause histiocytes to build up in certain parts of the body, such as the skin, lymph nodes, and spleen. | * '''[[Non-Langerhans cell histiocytosis]]''': This type includes a variety of conditions that cause histiocytes to build up in certain parts of the body, such as the skin, lymph nodes, and spleen. | ||
* '''[[Hemophagocytic lymphohistiocytosis]] (HLH)''': This is a severe form of histiocytosis that can affect many organs throughout the body. | * '''[[Hemophagocytic lymphohistiocytosis]] (HLH)''': This is a severe form of histiocytosis that can affect many organs throughout the body. | ||
==Symptoms== | ==Symptoms== | ||
The symptoms of histiocytosis can vary greatly depending on the type and severity of the condition. They may include: | The symptoms of histiocytosis can vary greatly depending on the type and severity of the condition. They may include: | ||
* [[Skin rash]] | * [[Skin rash]] | ||
* [[Bone pain]] | * [[Bone pain]] | ||
| Line 20: | Line 32: | ||
* [[Weight loss]] | * [[Weight loss]] | ||
* [[Fatigue]] | * [[Fatigue]] | ||
==Diagnosis== | ==Diagnosis== | ||
Histiocytosis is diagnosed through a combination of [[medical history]], physical examination, and laboratory tests. These may include: | Histiocytosis is diagnosed through a combination of [[medical history]], physical examination, and laboratory tests. These may include: | ||
* [[Blood tests]] | * [[Blood tests]] | ||
* [[Biopsy]] | * [[Biopsy]] | ||
* [[Imaging tests]] | * [[Imaging tests]] | ||
==Treatment== | ==Treatment== | ||
Treatment for histiocytosis depends on the type and severity of the condition. It may include: | Treatment for histiocytosis depends on the type and severity of the condition. It may include: | ||
* [[Chemotherapy]] | * [[Chemotherapy]] | ||
* [[Radiation therapy]] | * [[Radiation therapy]] | ||
* [[Immunotherapy]] | * [[Immunotherapy]] | ||
* [[Surgery]] | * [[Surgery]] | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for individuals with histiocytosis varies greatly. Some people may recover completely with treatment, while others may experience long-term complications or disability. | The prognosis for individuals with histiocytosis varies greatly. Some people may recover completely with treatment, while others may experience long-term complications or disability. | ||
==See Also== | ==See Also== | ||
* [[Immune system]] | * [[Immune system]] | ||
* [[Lymphatic system]] | * [[Lymphatic system]] | ||
* [[Cancer]] | * [[Cancer]] | ||
[[Category:Medical conditions]] | [[Category:Medical conditions]] | ||
[[Category:Immune system disorders]] | [[Category:Immune system disorders]] | ||
[[Category:Histiocytosis]] | [[Category:Histiocytosis]] | ||
{{stub}} | {{stub}} | ||
Latest revision as of 03:12, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Histiocytosis | |
|---|---|
.jpg)
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Varies by type; may include fever, weight loss, skin rash, bone pain |
| Complications | Organ dysfunction, bone lesions, diabetes insipidus |
| Onset | Usually in childhood |
| Duration | Varies |
| Types | Langerhans cell histiocytosis, Hemophagocytic lymphohistiocytosis, Rosai-Dorfman disease |
| Causes | Abnormal proliferation of histiocytes |
| Risks | Genetic factors, immune system dysregulation |
| Diagnosis | Biopsy, imaging studies, blood tests |
| Differential diagnosis | Infection, malignancy, autoimmune disease |
| Prevention | N/A |
| Treatment | Chemotherapy, radiation therapy, immunotherapy, surgery |
| Medication | N/A |
| Prognosis | Varies by type and severity |
| Frequency | Rare |
| Deaths | N/A |
Histiocytosis is a general name for a group of syndromes that involve an abnormal increase in the number of immune cells known as histiocytes. The disease can affect anyone from infants to older adults.
Types of Histiocytosis[edit]
There are several types of histiocytosis, including:
- Langerhans cell histiocytosis (LCH): This is the most common type of histiocytosis. LCH can damage skin, bones, and other parts of the body, or form tumors.
- Non-Langerhans cell histiocytosis: This type includes a variety of conditions that cause histiocytes to build up in certain parts of the body, such as the skin, lymph nodes, and spleen.
- Hemophagocytic lymphohistiocytosis (HLH): This is a severe form of histiocytosis that can affect many organs throughout the body.
Symptoms[edit]
The symptoms of histiocytosis can vary greatly depending on the type and severity of the condition. They may include:
Diagnosis[edit]
Histiocytosis is diagnosed through a combination of medical history, physical examination, and laboratory tests. These may include:
Treatment[edit]
Treatment for histiocytosis depends on the type and severity of the condition. It may include:
Prognosis[edit]
The prognosis for individuals with histiocytosis varies greatly. Some people may recover completely with treatment, while others may experience long-term complications or disability.
