Palisaded neutrophilic and granulomatous dermatitis: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{Infobox medical condition | |||
| name = Palisaded neutrophilic and granulomatous dermatitis | |||
| synonyms = PNGD | |||
| specialty = [[Dermatology]] | |||
| symptoms = [[Skin lesions]], [[papules]], [[nodules]] | |||
| complications = [[Ulceration]], [[scarring]] | |||
| onset = Variable | |||
| duration = Chronic | |||
| causes = Associated with [[autoimmune diseases]], [[rheumatoid arthritis]], [[systemic lupus erythematosus]], [[vasculitis]] | |||
| risks = [[Autoimmune disorders]], [[inflammatory conditions]] | |||
| diagnosis = [[Skin biopsy]], [[histopathology]] | |||
| differential = [[Rheumatoid nodules]], [[granuloma annulare]], [[necrobiosis lipoidica]] | |||
| treatment = [[Corticosteroids]], [[immunosuppressive therapy]] | |||
| prognosis = Variable, depends on underlying condition | |||
| frequency = Rare | |||
}} | |||
'''Palisaded Neutrophilic and Granulomatous Dermatitis''' (PNGD) is a rare [[skin condition]] characterized by the presence of [[neutrophil]]s and [[granuloma]]s in the [[dermis]]. It is considered a [[reactive process]] rather than a distinct [[disease]], often associated with systemic conditions such as [[rheumatoid arthritis]], [[systemic lupus erythematosus]], and other [[autoimmune diseases]]. The etiology of PNGD remains largely unknown, but it is thought to involve a complex interplay of genetic, immunologic, and environmental factors. | '''Palisaded Neutrophilic and Granulomatous Dermatitis''' (PNGD) is a rare [[skin condition]] characterized by the presence of [[neutrophil]]s and [[granuloma]]s in the [[dermis]]. It is considered a [[reactive process]] rather than a distinct [[disease]], often associated with systemic conditions such as [[rheumatoid arthritis]], [[systemic lupus erythematosus]], and other [[autoimmune diseases]]. The etiology of PNGD remains largely unknown, but it is thought to involve a complex interplay of genetic, immunologic, and environmental factors. | ||
==Symptoms and Diagnosis== | ==Symptoms and Diagnosis== | ||
The clinical presentation of PNGD can vary but typically includes tender or asymptomatic [[papules]], [[nodules]], and [[plaques]] that are red to violaceous in color. These lesions predominantly occur on the extremities, especially the elbows and fingers. Histologically, PNGD is characterized by a triad of features: a [[palisaded granuloma]] surrounding areas of degenerated [[collagen]], a dense [[inflammatory infiltrate]] rich in neutrophils, and [[leukocytoclasia]] without evidence of [[vasculitis]]. | The clinical presentation of PNGD can vary but typically includes tender or asymptomatic [[papules]], [[nodules]], and [[plaques]] that are red to violaceous in color. These lesions predominantly occur on the extremities, especially the elbows and fingers. Histologically, PNGD is characterized by a triad of features: a [[palisaded granuloma]] surrounding areas of degenerated [[collagen]], a dense [[inflammatory infiltrate]] rich in neutrophils, and [[leukocytoclasia]] without evidence of [[vasculitis]]. | ||
Diagnosis of PNGD is primarily based on the histopathological examination of a [[skin biopsy]]. Clinical correlation with systemic symptoms and serological tests may aid in identifying associated systemic diseases. | Diagnosis of PNGD is primarily based on the histopathological examination of a [[skin biopsy]]. Clinical correlation with systemic symptoms and serological tests may aid in identifying associated systemic diseases. | ||
==Treatment and Prognosis== | ==Treatment and Prognosis== | ||
Treatment of PNGD focuses on managing the underlying systemic condition, if identified. [[Corticosteroids]], both topical and systemic, are commonly used to reduce inflammation and control symptoms. Other treatments may include [[antimalarial drugs]], [[dapsone]], and [[immunosuppressive agents]], depending on the patient's overall health and associated conditions. | Treatment of PNGD focuses on managing the underlying systemic condition, if identified. [[Corticosteroids]], both topical and systemic, are commonly used to reduce inflammation and control symptoms. Other treatments may include [[antimalarial drugs]], [[dapsone]], and [[immunosuppressive agents]], depending on the patient's overall health and associated conditions. | ||
The prognosis of PNGD is generally good, with appropriate treatment leading to resolution of skin lesions. However, the underlying systemic disease may influence the overall outcome. | The prognosis of PNGD is generally good, with appropriate treatment leading to resolution of skin lesions. However, the underlying systemic disease may influence the overall outcome. | ||
==Epidemiology== | ==Epidemiology== | ||
PNGD is a rare condition, with limited epidemiological data available. It can occur at any age but is most commonly diagnosed in adults. There is no clear gender predilection. | PNGD is a rare condition, with limited epidemiological data available. It can occur at any age but is most commonly diagnosed in adults. There is no clear gender predilection. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The pathogenesis of PNGD is not fully understood. It is believed to involve an immune-mediated response, possibly triggered by an underlying systemic disease or environmental factors. The formation of granulomas is thought to be a reaction to an unknown antigen, with neutrophils playing a key role in the inflammatory process. | The pathogenesis of PNGD is not fully understood. It is believed to involve an immune-mediated response, possibly triggered by an underlying systemic disease or environmental factors. The formation of granulomas is thought to be a reaction to an unknown antigen, with neutrophils playing a key role in the inflammatory process. | ||
==See Also== | ==See Also== | ||
* [[Dermatitis]] | * [[Dermatitis]] | ||
| Line 23: | Line 33: | ||
* [[Systemic Lupus Erythematosus]] | * [[Systemic Lupus Erythematosus]] | ||
* [[Autoimmune Diseases]] | * [[Autoimmune Diseases]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Autoimmune Diseases]] | [[Category:Autoimmune Diseases]] | ||
[[Category:Skin Conditions]] | [[Category:Skin Conditions]] | ||
{{medicine-stub}} | {{medicine-stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 03:20, 4 April 2025
| Palisaded neutrophilic and granulomatous dermatitis | |
|---|---|
| Synonyms | PNGD |
| Pronounce | N/A |
| Specialty | Dermatology |
| Symptoms | Skin lesions, papules, nodules |
| Complications | Ulceration, scarring |
| Onset | Variable |
| Duration | Chronic |
| Types | N/A |
| Causes | Associated with autoimmune diseases, rheumatoid arthritis, systemic lupus erythematosus, vasculitis |
| Risks | Autoimmune disorders, inflammatory conditions |
| Diagnosis | Skin biopsy, histopathology |
| Differential diagnosis | Rheumatoid nodules, granuloma annulare, necrobiosis lipoidica |
| Prevention | N/A |
| Treatment | Corticosteroids, immunosuppressive therapy |
| Medication | N/A |
| Prognosis | Variable, depends on underlying condition |
| Frequency | Rare |
| Deaths | N/A |
Palisaded Neutrophilic and Granulomatous Dermatitis (PNGD) is a rare skin condition characterized by the presence of neutrophils and granulomas in the dermis. It is considered a reactive process rather than a distinct disease, often associated with systemic conditions such as rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune diseases. The etiology of PNGD remains largely unknown, but it is thought to involve a complex interplay of genetic, immunologic, and environmental factors.
Symptoms and Diagnosis[edit]
The clinical presentation of PNGD can vary but typically includes tender or asymptomatic papules, nodules, and plaques that are red to violaceous in color. These lesions predominantly occur on the extremities, especially the elbows and fingers. Histologically, PNGD is characterized by a triad of features: a palisaded granuloma surrounding areas of degenerated collagen, a dense inflammatory infiltrate rich in neutrophils, and leukocytoclasia without evidence of vasculitis. Diagnosis of PNGD is primarily based on the histopathological examination of a skin biopsy. Clinical correlation with systemic symptoms and serological tests may aid in identifying associated systemic diseases.
Treatment and Prognosis[edit]
Treatment of PNGD focuses on managing the underlying systemic condition, if identified. Corticosteroids, both topical and systemic, are commonly used to reduce inflammation and control symptoms. Other treatments may include antimalarial drugs, dapsone, and immunosuppressive agents, depending on the patient's overall health and associated conditions. The prognosis of PNGD is generally good, with appropriate treatment leading to resolution of skin lesions. However, the underlying systemic disease may influence the overall outcome.
Epidemiology[edit]
PNGD is a rare condition, with limited epidemiological data available. It can occur at any age but is most commonly diagnosed in adults. There is no clear gender predilection.
Pathophysiology[edit]
The pathogenesis of PNGD is not fully understood. It is believed to involve an immune-mediated response, possibly triggered by an underlying systemic disease or environmental factors. The formation of granulomas is thought to be a reaction to an unknown antigen, with neutrophils playing a key role in the inflammatory process.
