Clear-cell sarcoma of the kidney: Difference between revisions
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{{Infobox medical condition | |||
| name = Clear-cell sarcoma of the kidney | |||
| synonyms = [[CCSK]] | |||
| field = [[Oncology]], [[Nephrology]] | |||
| symptoms = [[Abdominal mass]], [[hematuria]], [[fever]], [[hypertension]] | |||
| complications = [[Metastasis]] | |||
| onset = Typically in [[children]] | |||
| duration = Variable | |||
| types = | |||
| causes = Unknown | |||
| risks = | |||
| diagnosis = [[Histopathology]], [[imaging studies]] | |||
| differential = [[Wilms' tumor]], [[rhabdoid tumor of the kidney]] | |||
| prevention = | |||
| treatment = [[Surgery]], [[chemotherapy]], [[radiation therapy]] | |||
| medication = | |||
| prognosis = Variable, depends on stage and response to treatment | |||
| frequency = Rare | |||
}} | |||
'''Clear-cell sarcoma of the kidney''' ('''CCSK''') is a rare type of [[kidney cancer]] that primarily affects children. It is characterized by its unique histological appearance, which is distinct from other pediatric renal tumors such as [[Wilms' tumor]] and [[renal cell carcinoma]]. | '''Clear-cell sarcoma of the kidney''' ('''CCSK''') is a rare type of [[kidney cancer]] that primarily affects children. It is characterized by its unique histological appearance, which is distinct from other pediatric renal tumors such as [[Wilms' tumor]] and [[renal cell carcinoma]]. | ||
==Epidemiology== | ==Epidemiology== | ||
CCSK accounts for approximately 2-4% of all pediatric renal tumors. It is most commonly diagnosed in children aged 2-4 years, but can occur at any age. The incidence is slightly higher in males than in females. | CCSK accounts for approximately 2-4% of all pediatric renal tumors. It is most commonly diagnosed in children aged 2-4 years, but can occur at any age. The incidence is slightly higher in males than in females. | ||
==Pathogenesis== | ==Pathogenesis== | ||
The exact cause of CCSK is unknown. However, it is believed to originate from the metanephric mesenchyme, the embryonic tissue that gives rise to the kidneys. Some cases have been associated with certain genetic abnormalities, such as the t(10;17)(q22;p13) translocation. | The exact cause of CCSK is unknown. However, it is believed to originate from the metanephric mesenchyme, the embryonic tissue that gives rise to the kidneys. Some cases have been associated with certain genetic abnormalities, such as the t(10;17)(q22;p13) translocation. | ||
==Clinical Features== | ==Clinical Features== | ||
Children with CCSK often present with a large, painless abdominal mass. Other symptoms may include [[hematuria]] (blood in the urine), [[hypertension]] (high blood pressure), and [[anemia]] (low red blood cell count). In some cases, the tumor may spread to other parts of the body, most commonly the lungs and bones. | Children with CCSK often present with a large, painless abdominal mass. Other symptoms may include [[hematuria]] (blood in the urine), [[hypertension]] (high blood pressure), and [[anemia]] (low red blood cell count). In some cases, the tumor may spread to other parts of the body, most commonly the lungs and bones. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of CCSK is typically made based on the results of imaging studies, such as [[ultrasound]] or [[computed tomography]] (CT) scan, and confirmed by [[biopsy]] of the tumor. The tumor has a characteristic appearance under the microscope, with clear cells arranged in nests or cords. | The diagnosis of CCSK is typically made based on the results of imaging studies, such as [[ultrasound]] or [[computed tomography]] (CT) scan, and confirmed by [[biopsy]] of the tumor. The tumor has a characteristic appearance under the microscope, with clear cells arranged in nests or cords. | ||
==Treatment== | ==Treatment== | ||
The standard treatment for CCSK includes surgery to remove the tumor, followed by [[chemotherapy]] and/or [[radiation therapy]]. The choice of treatment depends on the stage of the disease and the patient's overall health. | The standard treatment for CCSK includes surgery to remove the tumor, followed by [[chemotherapy]] and/or [[radiation therapy]]. The choice of treatment depends on the stage of the disease and the patient's overall health. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for children with CCSK is generally good, with a 5-year survival rate of approximately 80-90%. However, the prognosis can be significantly worse for children with advanced disease or those who experience a recurrence. | The prognosis for children with CCSK is generally good, with a 5-year survival rate of approximately 80-90%. However, the prognosis can be significantly worse for children with advanced disease or those who experience a recurrence. | ||
==See Also== | ==See Also== | ||
* [[Kidney cancer]] | * [[Kidney cancer]] | ||
| Line 24: | Line 37: | ||
* [[Wilms' tumor]] | * [[Wilms' tumor]] | ||
* [[Renal cell carcinoma]] | * [[Renal cell carcinoma]] | ||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
[[Category:Cancers]] | [[Category:Cancers]] | ||
[[Category:Pediatric diseases]] | [[Category:Pediatric diseases]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
{{Kidney-disease-stub}} | {{Kidney-disease-stub}} | ||
{{Cancer-stub}} | {{Cancer-stub}} | ||
{{Medicine-stub}} | {{Medicine-stub}} | ||
{{No image}} | {{No image}} | ||
Latest revision as of 23:47, 3 April 2025
| Clear-cell sarcoma of the kidney | |
|---|---|
| Synonyms | CCSK |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Abdominal mass, hematuria, fever, hypertension |
| Complications | Metastasis |
| Onset | Typically in children |
| Duration | Variable |
| Types | |
| Causes | Unknown |
| Risks | |
| Diagnosis | Histopathology, imaging studies |
| Differential diagnosis | Wilms' tumor, rhabdoid tumor of the kidney |
| Prevention | |
| Treatment | Surgery, chemotherapy, radiation therapy |
| Medication | |
| Prognosis | Variable, depends on stage and response to treatment |
| Frequency | Rare |
| Deaths | N/A |
Clear-cell sarcoma of the kidney (CCSK) is a rare type of kidney cancer that primarily affects children. It is characterized by its unique histological appearance, which is distinct from other pediatric renal tumors such as Wilms' tumor and renal cell carcinoma.
Epidemiology[edit]
CCSK accounts for approximately 2-4% of all pediatric renal tumors. It is most commonly diagnosed in children aged 2-4 years, but can occur at any age. The incidence is slightly higher in males than in females.
Pathogenesis[edit]
The exact cause of CCSK is unknown. However, it is believed to originate from the metanephric mesenchyme, the embryonic tissue that gives rise to the kidneys. Some cases have been associated with certain genetic abnormalities, such as the t(10;17)(q22;p13) translocation.
Clinical Features[edit]
Children with CCSK often present with a large, painless abdominal mass. Other symptoms may include hematuria (blood in the urine), hypertension (high blood pressure), and anemia (low red blood cell count). In some cases, the tumor may spread to other parts of the body, most commonly the lungs and bones.
Diagnosis[edit]
The diagnosis of CCSK is typically made based on the results of imaging studies, such as ultrasound or computed tomography (CT) scan, and confirmed by biopsy of the tumor. The tumor has a characteristic appearance under the microscope, with clear cells arranged in nests or cords.
Treatment[edit]
The standard treatment for CCSK includes surgery to remove the tumor, followed by chemotherapy and/or radiation therapy. The choice of treatment depends on the stage of the disease and the patient's overall health.
Prognosis[edit]
The prognosis for children with CCSK is generally good, with a 5-year survival rate of approximately 80-90%. However, the prognosis can be significantly worse for children with advanced disease or those who experience a recurrence.
See Also[edit]
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