Estradiol undecylate

Estradiol undecylate is a synthetic, steroidal estrogen that is used in hormone therapy. It is a long-acting ester of estradiol, the primary female sex hormone. Estradiol undecylate is not currently marketed in any country, but it was previously available as a medication in France and possibly other countries.

Pharmacology

Estradiol undecylate is a prodrug of estradiol, which means it is inactive itself but is converted into the active hormone estradiol in the body. It is administered by intramuscular injection and has a very long duration of action due to its long fatty acid ester.

Chemistry

Estradiol undecylate is a synthetic estrane steroid and a derivative of estradiol. It is an estradiol ester, or a prodrug of estradiol. The undecylate ester is attached to the 17-beta hydroxyl group of estradiol, which makes the molecule more lipophilic and increases its half-life.

History

Estradiol undecylate was previously marketed in France under the brand name Progynon Depot 100, but it is no longer available. It is not known if it was marketed in other countries.

See also

• List of estrogen esters
• Estradiol valerate
• Estradiol cypionate

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Estradiol undecylate

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  Estradiol undecylate
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  Testosterone levels with 300 mg per week cyproterone acetate and 100 mg per month estradiol undecylate by intramuscular injection
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  Estradiol, testosterone, and prolactin levels during therapy with 100 mg per month estradiol undecylate in men with prostate cancer
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  Estradiol levels after a single intramuscular injection of 10 mg estradiol valerate and 100 mg estradiol undecylate
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  Estradiol levels after injections of estradiol, estradiol benzoate, estradiol valerate, and estradiol undecylate in women
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  Hormone levels with an intramuscular injection of estradiol undecylate in postmenopausal women