Sulfalene: Difference between revisions
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'''Sulfalene''' is a | == Sulfalene == | ||
[[File:Sulfalene2DCSD.svg|thumb|right|Chemical structure of Sulfalene]] | |||
'''Sulfalene''' is a [[sulfonamide]] [[antibiotic]] that is used in the treatment of various bacterial infections. It belongs to the class of drugs known as [[sulfa drugs]], which are synthetic antimicrobial agents that contain the sulfonamide group. Sulfalene is known for its long-acting properties and is often used in combination with other antibiotics to enhance its effectiveness. | |||
== Mechanism of Action == | == Mechanism of Action == | ||
Sulfalene | Sulfalene works by inhibiting the bacterial enzyme [[dihydropteroate synthase]], which is crucial for the synthesis of [[folic acid]] in bacteria. Folic acid is necessary for the production of [[nucleic acids]] and ultimately for bacterial growth and replication. By blocking this enzyme, sulfalene effectively halts the growth of bacteria, allowing the body's immune system to eliminate the infection. | ||
== | == Clinical Uses == | ||
Sulfalene is | Sulfalene is primarily used to treat infections caused by susceptible strains of bacteria. It is often prescribed for: | ||
* [[Urinary tract infections]] | |||
* [[Respiratory tract infections]] | |||
* [[Gastrointestinal infections]] | |||
Due to its long half-life, sulfalene is particularly useful in situations where prolonged antibiotic coverage is desired. | |||
== Side Effects == | == Side Effects == | ||
As with other sulfonamides, sulfalene can cause a range of side effects. Common side effects include: | |||
* [[Nausea]] | |||
* [[Vomiting]] | |||
* [[Rash]] | |||
More serious side effects, although rare, can include: | |||
* [[Stevens-Johnson syndrome]] | |||
* [[Agranulocytosis]] | |||
* [[Hepatotoxicity]] | |||
Patients with a known allergy to sulfonamides should avoid using sulfalene. | |||
== Pharmacokinetics == | |||
Sulfalene is well absorbed from the gastrointestinal tract and is widely distributed throughout the body. It is metabolized in the liver and excreted primarily in the urine. The drug has a long half-life, which allows for once-daily dosing in most cases. | |||
== Related Pages == | |||
[[ | * [[Sulfonamide (medicine)]] | ||
[[ | * [[Antibiotic]] | ||
[[ | * [[Bacterial infection]] | ||
[[Category:Sulfonamide antibiotics]] | |||
Latest revision as of 04:03, 13 February 2025
Sulfalene[edit]
Sulfalene is a sulfonamide antibiotic that is used in the treatment of various bacterial infections. It belongs to the class of drugs known as sulfa drugs, which are synthetic antimicrobial agents that contain the sulfonamide group. Sulfalene is known for its long-acting properties and is often used in combination with other antibiotics to enhance its effectiveness.
Mechanism of Action[edit]
Sulfalene works by inhibiting the bacterial enzyme dihydropteroate synthase, which is crucial for the synthesis of folic acid in bacteria. Folic acid is necessary for the production of nucleic acids and ultimately for bacterial growth and replication. By blocking this enzyme, sulfalene effectively halts the growth of bacteria, allowing the body's immune system to eliminate the infection.
Clinical Uses[edit]
Sulfalene is primarily used to treat infections caused by susceptible strains of bacteria. It is often prescribed for:
Due to its long half-life, sulfalene is particularly useful in situations where prolonged antibiotic coverage is desired.
Side Effects[edit]
As with other sulfonamides, sulfalene can cause a range of side effects. Common side effects include:
More serious side effects, although rare, can include:
Patients with a known allergy to sulfonamides should avoid using sulfalene.
Pharmacokinetics[edit]
Sulfalene is well absorbed from the gastrointestinal tract and is widely distributed throughout the body. It is metabolized in the liver and excreted primarily in the urine. The drug has a long half-life, which allows for once-daily dosing in most cases.
