Enramycin: Difference between revisions

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'''Enramycin''' is an [[antibiotic]] that is primarily used in [[veterinary medicine]]. It is a polypeptide antibiotic that is derived from the actinomycete ''[[Streptomyces fungicidicus]]''. Enramycin is used to treat [[Gram-positive bacteria]] and has a unique mechanism of action that is not fully understood.
{{Short description|An overview of the antibiotic enramycin}}
{{Drugbox}}


== History ==
==Overview==
[[File:Enramycins.png|thumb|right|Chemical structure of enramycin]]
'''Enramycin''' is a polypeptide antibiotic primarily used in veterinary medicine. It is produced by the bacterium ''[[Streptomyces fungicidicus]]'' and is effective against a range of Gram-positive bacteria. Enramycin is commonly used as a feed additive to promote growth and improve feed efficiency in livestock, particularly in poultry and swine.


Enramycin was first isolated in Japan in the 1960s from ''Streptomyces fungicidicus''. It was initially used in the poultry industry to improve feed efficiency and growth rate. Since then, it has been used in a variety of other livestock animals, including pigs and cattle.
==Mechanism of Action==
Enramycin works by inhibiting the synthesis of the bacterial cell wall. It binds to the [[peptidoglycan]] precursors, preventing their incorporation into the cell wall and thereby disrupting the integrity of the bacterial cell. This leads to cell lysis and death of the bacterium.


== Mechanism of Action ==
==Uses in Veterinary Medicine==
Enramycin is used as a growth promoter in animal husbandry. It is added to animal feed to enhance growth rates and improve feed conversion ratios. This use is particularly prevalent in the poultry and swine industries. The antibiotic properties of enramycin help to maintain gut health by controlling pathogenic bacteria, thereby improving nutrient absorption and overall animal health.


Enramycin is believed to inhibit the synthesis of the bacterial cell wall, leading to cell death. It is also thought to bind to the 50S subunit of the bacterial ribosome, inhibiting protein synthesis. However, the exact mechanism of action is not fully understood.
==Safety and Regulation==
[[File:Enramycins.png|thumb|left|Enramycin in veterinary use]]
The use of enramycin in animal feed is regulated in many countries to ensure food safety and prevent the development of antibiotic-resistant bacteria. Regulatory agencies set maximum residue limits (MRLs) for enramycin in animal products to ensure that meat and other products are safe for human consumption.


== Use in Veterinary Medicine ==
==Resistance==
As with other antibiotics, there is a concern about the development of resistance to enramycin. Continuous monitoring and prudent use of enramycin in animal agriculture are essential to mitigate the risk of resistance. Research is ongoing to understand the mechanisms of resistance and to develop strategies to counteract it.


In veterinary medicine, enramycin is used to treat a variety of bacterial infections, particularly those caused by Gram-positive bacteria. It is also used as a growth promoter in livestock animals.
==Related pages==
 
* [[Antibiotic resistance]]
== Side Effects ==
* [[Veterinary medicine]]
 
* [[Feed additive]]
As with all antibiotics, enramycin can cause side effects. These can include allergic reactions, digestive upset, and changes in the balance of gut bacteria. In rare cases, it can cause more serious side effects, such as kidney damage.
 
== Resistance ==
 
As with all antibiotics, there is a risk of bacteria developing resistance to enramycin. This is a major concern in both human and veterinary medicine.
 
== See Also ==
 
* [[Antibiotics]]
* [[Veterinary Medicine]]
* [[Gram-positive bacteria]]
* [[Streptomyces]]
* [[Streptomyces]]
== References ==
{{reflist}}


[[Category:Antibiotics]]
[[Category:Antibiotics]]
[[Category:Veterinary Medicine]]
[[Category:Veterinary drugs]]
[[Category:Pharmacology]]
 
{{pharmacology-stub}}

Latest revision as of 03:54, 13 February 2025

An overview of the antibiotic enramycin


Enramycin
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Overview[edit]

Chemical structure of enramycin

Enramycin is a polypeptide antibiotic primarily used in veterinary medicine. It is produced by the bacterium Streptomyces fungicidicus and is effective against a range of Gram-positive bacteria. Enramycin is commonly used as a feed additive to promote growth and improve feed efficiency in livestock, particularly in poultry and swine.

Mechanism of Action[edit]

Enramycin works by inhibiting the synthesis of the bacterial cell wall. It binds to the peptidoglycan precursors, preventing their incorporation into the cell wall and thereby disrupting the integrity of the bacterial cell. This leads to cell lysis and death of the bacterium.

Uses in Veterinary Medicine[edit]

Enramycin is used as a growth promoter in animal husbandry. It is added to animal feed to enhance growth rates and improve feed conversion ratios. This use is particularly prevalent in the poultry and swine industries. The antibiotic properties of enramycin help to maintain gut health by controlling pathogenic bacteria, thereby improving nutrient absorption and overall animal health.

Safety and Regulation[edit]

Enramycin in veterinary use

The use of enramycin in animal feed is regulated in many countries to ensure food safety and prevent the development of antibiotic-resistant bacteria. Regulatory agencies set maximum residue limits (MRLs) for enramycin in animal products to ensure that meat and other products are safe for human consumption.

Resistance[edit]

As with other antibiotics, there is a concern about the development of resistance to enramycin. Continuous monitoring and prudent use of enramycin in animal agriculture are essential to mitigate the risk of resistance. Research is ongoing to understand the mechanisms of resistance and to develop strategies to counteract it.

Related pages[edit]