Enramycin

An overview of the antibiotic enramycin

Enramycin
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Overview

Chemical structure of enramycin

Enramycin is a polypeptide antibiotic primarily used in veterinary medicine. It is produced by the bacterium Streptomyces fungicidicus and is effective against a range of Gram-positive bacteria. Enramycin is commonly used as a feed additive to promote growth and improve feed efficiency in livestock, particularly in poultry and swine.

Mechanism of Action

Enramycin works by inhibiting the synthesis of the bacterial cell wall. It binds to the peptidoglycan precursors, preventing their incorporation into the cell wall and thereby disrupting the integrity of the bacterial cell. This leads to cell lysis and death of the bacterium.

Uses in Veterinary Medicine

Enramycin is used as a growth promoter in animal husbandry. It is added to animal feed to enhance growth rates and improve feed conversion ratios. This use is particularly prevalent in the poultry and swine industries. The antibiotic properties of enramycin help to maintain gut health by controlling pathogenic bacteria, thereby improving nutrient absorption and overall animal health.

Safety and Regulation

Enramycin in veterinary use

The use of enramycin in animal feed is regulated in many countries to ensure food safety and prevent the development of antibiotic-resistant bacteria. Regulatory agencies set maximum residue limits (MRLs) for enramycin in animal products to ensure that meat and other products are safe for human consumption.

Resistance

As with other antibiotics, there is a concern about the development of resistance to enramycin. Continuous monitoring and prudent use of enramycin in animal agriculture are essential to mitigate the risk of resistance. Research is ongoing to understand the mechanisms of resistance and to develop strategies to counteract it.

Related pages

• Antibiotic resistance
• Veterinary medicine
• Feed additive
• Streptomyces