Testosterone phenylpropionate: Difference between revisions

Testosterone phenylpropionate
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Latest revision as of 02:57, 11 December 2024

An overview of Testosterone phenylpropionate

Testosterone phenylpropionate is an androgen and anabolic steroid (AAS) and a testosterone ester. It was formerly used in medicine but is now mostly used in veterinary medicine.

Pharmacology[edit]

Testosterone phenylpropionate is a synthetic androgen and anabolic steroid and an androgen ester; specifically, it is the C17β phenylpropionate (phenylpropanoate) ester of testosterone.

Mechanism of Action[edit]

As an androgen, testosterone phenylpropionate binds to the androgen receptor, activating it and leading to the expression of specific genes. This results in the development and maintenance of male secondary sexual characteristics and the promotion of muscle growth.

Pharmacokinetics[edit]

Testosterone phenylpropionate is administered via intramuscular injection. It has a relatively long half-life and duration of action due to the presence of the phenylpropionate ester, which slows the release of testosterone into the bloodstream.

Medical Uses[edit]

Testosterone phenylpropionate was used in the past for the treatment of male hypogonadism, andropause, and certain types of breast cancer in women. However, it has largely been replaced by other testosterone esters with more favorable pharmacokinetic profiles.

Side Effects[edit]

Common side effects of testosterone phenylpropionate include acne, oily skin, hair loss, and increased aggression. Long-term use can lead to cardiovascular disease, liver damage, and infertility.

History[edit]

Testosterone phenylpropionate was first synthesized in the 1950s and was used in clinical practice for several decades. It was marketed under various brand names, including Testolent and Testoviron.

Veterinary Use[edit]

In veterinary medicine, testosterone phenylpropionate is used to promote growth and improve feed efficiency in livestock.

Also see[edit]

References[edit]

@@ Line 1: / Line 1: @@
-[[File:Testosterone phenpropionate.svg|thumb|right|Chemical structure of Testosterone Phenylpropionate.]]
+{{Short description|An overview of Testosterone phenylpropionate}}
+{{Drugbox
+| Verifiedfields = changed
+| verifiedrevid = 477002308
+| IUPAC_name = 17β-Hydroxyandrost-4-en-3-one 3-phenylpropionate
+| image = Testosterone phenpropionate.svg
+| width = 200px
+}}
-'''Testosterone phenylpropionate''' is a synthetic testosterone ester and a medication used in hormone replacement therapy (HRT) and for the treatment of various testosterone-related conditions. It is classified as an androgen and an anabolic steroid.
+'''Testosterone phenylpropionate''' is an [[androgen]] and [[anabolic steroid]] (AAS) and a [[testosterone]] [[ester]]. It was formerly used in [[medicine]] but is now mostly used in [[veterinary medicine]].
-== Chemical Properties ==
+==Pharmacology==
-Testosterone phenylpropionate is a synthetic compound with chemical formula C28H36O3. It is derived from testosterone by the addition of a phenylpropionate ester group.
+Testosterone phenylpropionate is a synthetic [[androgen]] and [[anabolic steroid]] and an [[androgen ester]]; specifically, it is the C17β [[phenylpropionate]] (phenylpropanoate) [[ester]] of [[testosterone]].
-== Medical Uses ==
+===Mechanism of Action===
-Testosterone phenylpropionate is used medically for the following purposes:
+As an [[androgen]], testosterone phenylpropionate binds to the [[androgen receptor]], activating it and leading to the expression of specific genes. This results in the development and maintenance of [[male secondary sexual characteristics]] and the promotion of [[muscle growth]].
-* '''Hormone Replacement Therapy (HRT)''': It is prescribed to individuals with testosterone deficiency to supplement testosterone levels and alleviate associated symptoms such as fatigue, low libido, and mood changes.
-* '''Treatment of Hypogonadism''': Testosterone phenylpropionate is used in the management of hypogonadism, a condition where the testes do not produce enough testosterone.
+===Pharmacokinetics===
+Testosterone phenylpropionate is administered via [[intramuscular injection]]. It has a relatively long half-life and duration of action due to the presence of the phenylpropionate ester, which slows the release of testosterone into the bloodstream.
-* '''Supportive Care in Certain Illnesses''': In some medical conditions like cancer, it may be used to support muscle growth and overall well-being.
+==Medical Uses==
+Testosterone phenylpropionate was used in the past for the treatment of [[male hypogonadism]], [[andropause]], and certain types of [[breast cancer]] in women. However, it has largely been replaced by other testosterone esters with more favorable pharmacokinetic profiles.
-== Administration ==
+==Side Effects==
-Testosterone phenylpropionate is typically administered via intramuscular injection. The frequency and dosage of injections are determined by a healthcare professional based on the individual's needs and medical condition.
+Common side effects of testosterone phenylpropionate include [[acne]], [[oily skin]], [[hair loss]], and [[increased aggression]]. Long-term use can lead to [[cardiovascular disease]], [[liver damage]], and [[infertility]].
-== Safety and Regulation ==
+==History==
-The use of testosterone phenylpropionate in hormone replacement therapy is regulated and should be prescribed and monitored by healthcare professionals. It may have side effects and should be used with caution, particularly in cases of testosterone abuse.
+Testosterone phenylpropionate was first synthesized in the 1950s and was used in [[clinical practice]] for several decades. It was marketed under various brand names, including Testolent and Testoviron.
-== Research and Studies ==
+==Veterinary Use==
-Research on testosterone phenylpropionate continues to explore its effectiveness in hormone replacement therapy, its safety profile, and its role in improving the quality of life for individuals with testosterone deficiency.
+In veterinary medicine, testosterone phenylpropionate is used to promote growth and improve feed efficiency in livestock.
-== Summary ==
+==Also see==
-Testosterone phenylpropionate (BAN; TPP) (brand name Testolent), or testosterone phenpropionate, also known as testosterone hydrocinnamate, is a synthetic anabolic-androgenic steroid (AAS) and an androgen ester. It was first synthesized in 1951 and was first described in the literature by 1953. The medication was an ingredient of several isolated AAS commercial products, but was never widely used. Testosterone phenylpropionate was also notably a component of Sustanon and Omnadren, as well as of Estandron Prolongatum, Lynandron Prolongatum, and Mixogen.
+* [[Testosterone]]
-{{stubd}}
+* [[Anabolic steroid]]
-[[Category:Chemical Compounds]]
+* [[Androgen receptor]]
-[[Category:Hormone Replacement Therapy]]
+* [[Testosterone enanthate]]
-[[Category:Androgens]]
+* [[Testosterone cypionate]]
-[[Category:Anabolic Steroids]]
-[[Category:Testosterone]]
+==References==
+{{Reflist}}
+[[Category:Androgens and anabolic steroids]]
+[[Category:Testosterone esters]]
+[[Category:Veterinary drugs]]