Myelopoiesis
Myelopoiesis
Myelopoiesis (pronunciation: my·elo·poi·e·sis) is a biological process in the bone marrow where the production of blood cells, specifically myeloid cells, takes place.
Etymology
The term "myelopoiesis" is derived from the Greek words "myelos" meaning marrow and "poiesis" meaning production.
Process
Myelopoiesis involves the differentiation and maturation of hematopoietic stem cells (HSCs) into mature myeloid cells. These include granulocytes (neutrophils, eosinophils, and basophils), monocytes, and megakaryocytes which further differentiate into platelets.
Regulation
The process of myelopoiesis is regulated by various growth factors and cytokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), and interleukin-3 (IL-3).
Clinical Significance
Abnormal myelopoiesis can lead to a variety of blood disorders, including leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms.
Related Terms
- Hematopoiesis: The process of blood cell production, including myelopoiesis.
- Erythropoiesis: The process of producing red blood cells.
- Lymphopoiesis: The process of producing lymphocytes.
External links
- Medical encyclopedia article on Myelopoiesis
- Wikipedia's article - Myelopoiesis
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