Lefamulin
Lefamulin
Lefamulin (pronounced leh-fam-yoo-lin) is a pleuromutilin antibiotic drug used for the treatment of community-acquired bacterial pneumonia (CABP). It is marketed under the brand name Xenleta by Nabriva Therapeutics.
Etymology
The term "Lefamulin" is derived from the class of antibiotics it belongs to, known as pleuromutilin, and the suffix "-lin" which is common in many antibiotic names.
Usage
Lefamulin is used to treat adults with community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms, including Streptococcus pneumoniae, Staphylococcus aureus (methicillin-susceptible isolates), Haemophilus influenzae, Legionella pneumophila, Moraxella catarrhalis, and Mycoplasma pneumoniae.
Mechanism of Action
Lefamulin inhibits bacterial protein synthesis by binding to the peptidyl transferase center on the 50S subunit of the bacterial ribosome, thereby inhibiting the formation of peptide bonds during protein synthesis.
Side Effects
Common side effects of Lefamulin include nausea, diarrhea, vomiting, insomnia, and elevated liver enzymes. Serious side effects may include QT prolongation, Clostridium difficile-associated diarrhea, and hypersensitivity reactions.
Related Terms
- Pleuromutilin
- Community-acquired bacterial pneumonia
- Streptococcus pneumoniae
- Staphylococcus aureus
- Haemophilus influenzae
- Legionella pneumophila
- Moraxella catarrhalis
- Mycoplasma pneumoniae
- Peptidyl transferase
- Nausea
- Diarrhea
- Vomiting
- Insomnia
- Elevated liver enzymes
- QT prolongation
- Clostridium difficile-associated diarrhea
- Hypersensitivity reactions
External links
- Medical encyclopedia article on Lefamulin
- Wikipedia's article - Lefamulin
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski