Xanax Xr
Xanax XR is a brand name for the extended-release formulation of alprazolam, a benzodiazepine medication primarily used for the treatment of anxiety disorders and panic disorder. Alprazolam works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which helps to induce a calming effect. Xanax XR is designed to release the medication slowly over time, providing prolonged relief from anxiety symptoms without the need for frequent dosing.
Medical Uses
Xanax XR is indicated for the management of anxiety disorders or the short-term relief of symptoms of anxiety. It is also used in the treatment of panic disorder, with or without agoraphobia. This extended-release form is particularly beneficial for patients requiring steady blood levels of alprazolam throughout the day.
Pharmacology
The active ingredient in Xanax XR, alprazolam, belongs to the benzodiazepine class of drugs, which act on the central nervous system by enhancing the effect of GABA, a neurotransmitter that inhibits activity in the brain. This action results in the sedative, anxiolytic (anti-anxiety), muscle relaxant, and anticonvulsant effects of the medication.
Side Effects
Common side effects of Xanax XR include drowsiness, dizziness, fatigue, and impaired coordination. Less common but more serious side effects can include memory problems, depression, and withdrawal symptoms upon discontinuation, especially if the medication is stopped abruptly.
Dependence and Withdrawal
Long-term use of Xanax XR can lead to dependence, characterized by a need to continue taking the drug to avoid withdrawal symptoms. Withdrawal symptoms can include anxiety, insomnia, headache, and, in severe cases, seizures. It is important for patients to work closely with their healthcare provider to gradually taper off the medication when discontinuing use.
Dosage and Administration
Xanax XR is available in several dosage strengths. The dose and frequency of administration depend on the individual's condition and response to treatment. It is important to follow the prescribing physician's instructions closely and not to adjust the dose or frequency without consultation.
Precautions
Before taking Xanax XR, patients should inform their healthcare provider about any medical history of substance use disorder, liver disease, kidney disease, or respiratory problems. Caution is advised when using this medication in the elderly, as they may be more sensitive to its effects.
Interactions
Xanax XR can interact with other medications, leading to increased side effects or reduced effectiveness. These include other central nervous system depressants, alcohol, and certain medications metabolized by the liver. Patients should provide a complete list of their current medications to their healthcare provider to avoid potential interactions.
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Contributors: Prab R. Tumpati, MD