Wallerian degeneration

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Wallerian Degeneration

Wallerian degeneration (pronunciation: /wɔːˈlɪəriən dɪˌdʒɛnəˈreɪʃən/) is a process that results when a nerve fiber is cut or crushed, in which the part of the axon separated from the neuron's cell body degenerates distal to the injury. This is also known as anterograde or ascending degeneration.

Etymology

The term is named after the British neurologist, Augustus Volney Waller, who described the process in 1850.

Process

Wallerian degeneration occurs after the axon of a nerve is severed. The part of the axon connected to the cell body survives and can regenerate, while the part of the axon separated from the cell body degenerates. This process involves the breakdown of the myelin sheath, a protective layer that surrounds the axon.

Related Terms

  • Neuron: A nerve cell that is the basic building block of the nervous system.
  • Axon: A long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neuron's cell body.
  • Myelin Sheath: A layer of fatty tissue encasing a neuron's axon that provides insulation, protection, and speeds up the transmission of nerve impulses.
  • Nervous System: The network of nerve cells and fibers that transmits nerve signals between different parts of the body.

See Also

External links

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