Unconjugated bilirubin

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Unconjugated Bilirubin

Unconjugated bilirubin (pronunciation: un·con·ju·gat·ed bil·i·ru·bin) is a form of bilirubin that has not yet undergone a process known as conjugation.

Etymology

The term "unconjugated" is derived from the Latin unus, meaning "not", and conjugare, meaning "to join together". "Bilirubin" is derived from the Latin bilis, meaning "bile", and rubrum, meaning "red".

Definition

Unconjugated bilirubin is a yellowish substance produced during the normal breakdown of red blood cells. It is transported in the bloodstream to the liver, where it is converted into a water-soluble form known as conjugated bilirubin.

Related Terms

  • Bilirubin: A yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates.
  • Conjugated bilirubin: Bilirubin that has undergone conjugation in the liver and is excreted in bile.
  • Jaundice: A condition characterized by a yellowish discoloration of the skin and eyes, often due to elevated levels of bilirubin in the bloodstream.
  • Hemolysis: The rupture or destruction of red blood cells, which can lead to increased levels of unconjugated bilirubin.
  • Gilbert's syndrome: A common and harmless condition where the liver does not process bilirubin effectively, leading to an excess of unconjugated bilirubin.

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