Testosterone furoate
Overview[edit]
Testosterone furoate is a synthetic androgen and anabolic steroid (AAS) that is used in androgen replacement therapy for the treatment of male hypogonadism. It is an ester of testosterone, the primary male sex hormone and an anabolic steroid. Testosterone furoate is designed to provide a prolonged release of testosterone when administered, allowing for less frequent dosing compared to other testosterone formulations.
Chemical Structure[edit]
Testosterone furoate is characterized by the presence of a furoate ester group attached to the 17-beta hydroxyl group of the testosterone molecule. This modification increases the lipophilicity of the compound, enhancing its duration of action when administered intramuscularly.
Mechanism of Action[edit]
Testosterone furoate acts as an agonist of the androgen receptor, the biological target of testosterone and other androgens. Upon binding to the androgen receptor, testosterone furoate exerts its effects by modulating the expression of specific genes, leading to the development and maintenance of male secondary sexual characteristics and anabolic effects such as increased muscle mass and bone density.
Clinical Use[edit]
Testosterone furoate is primarily used in the treatment of conditions associated with low testosterone levels, such as hypogonadism in males. It may also be used in certain cases of delayed puberty and to support transgender hormone therapy in transgender men.
Administration[edit]
Testosterone furoate is typically administered via intramuscular injection. The esterification of testosterone with furoate allows for a slow release of the hormone into the bloodstream, which can maintain therapeutic levels over an extended period, reducing the frequency of injections required.
Side Effects[edit]
As with other testosterone formulations, testosterone furoate may cause side effects such as acne, oily skin, increased red blood cell count, and potential cardiovascular issues. Long-term use can also lead to suppression of the hypothalamic-pituitary-gonadal axis, resulting in decreased spermatogenesis and potential infertility.
Related Pages[edit]
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
