TGFBR3
(Redirected from TGFβR3)
Transforming Growth Factor Beta Receptor III (TGFBR3), also known as betaglycan, is a type of protein that in humans is encoded by the TGFBR3 gene. It is a component of the cell membrane and acts as a co-receptor in the transforming growth factor beta (TGF-β) signaling pathway. This pathway plays a critical role in regulating cell growth, cell differentiation, embryonic development, and immune system responses. TGFBR3 has been implicated in various biological processes and diseases, including cancer, cardiovascular diseases, and fibrosis.
Function
TGFBR3 is a membrane proteoglycan that presents ligands to the TGF-β receptors, TGFBR1 and TGFBR2, thereby facilitating ligand-receptor interactions and enhancing the response to TGF-β. Unlike TGFBR1 and TGFBR2, which are serine/threonine kinase receptors, TGFBR3 does not have intrinsic kinase activity. Instead, it modulates the signaling pathway by binding to TGF-β ligands and presenting them to the signaling receptors, acting as a reservoir for these ligands on the cell surface.
Structure
The TGFBR3 protein is characterized by a large extracellular domain, a single transmembrane domain, and a short cytoplasmic domain. The extracellular domain is responsible for ligand binding, while the cytoplasmic domain interacts with other proteins within the cell to mediate signal transduction.
Clinical Significance
Alterations in TGFBR3 expression or function have been associated with several pathological conditions. In cancer, TGFBR3 can have dual roles, acting as a tumor suppressor in early stages of tumor development by inhibiting cell proliferation and promoting apoptosis, and as a promoter of tumor progression and metastasis in later stages by enhancing cell migration and invasion. The loss of TGFBR3 expression has been observed in various types of cancer, including breast, prostate, and pancreatic cancers.
In cardiovascular diseases, TGFBR3 has been implicated in the regulation of vascular development and the pathogenesis of atherosclerosis. Its role in fibrosis involves the regulation of extracellular matrix production and the modulation of fibroblast activity.
Genetics
The TGFBR3 gene is located on human chromosome 1q41. Mutations in this gene have been studied in the context of their association with diseases, although such mutations are relatively rare. The gene's regulation is complex and involves various transcription factors and epigenetic mechanisms.
Therapeutic Implications
Given its role in TGF-β signaling and disease pathogenesis, TGFBR3 is considered a potential therapeutic target. Strategies to modulate TGFBR3 activity include the use of monoclonal antibodies, small molecule inhibitors, and gene therapy approaches. These therapies aim to restore normal TGFBR3 function in diseases where it is dysregulated.
See Also
References
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD