TAS2R45

TAS2R45 is a protein that in humans is encoded by the TAS2R45 gene. It is a member of the bitter taste receptor family, which is a group of G protein-coupled receptors. These receptors are specifically located on the taste buds in the mouth and are responsible for the perception of bitter taste.

Function

The TAS2R45 protein is a taste receptor, specifically a bitter taste receptor. It is one of the 25 human bitter taste receptors and is encoded by the TAS2R45 gene. The protein is expressed in the taste bud cells and is activated by certain chemicals found in food, leading to the perception of bitterness.

Gene

The TAS2R45 gene is located on chromosome 12 in humans. It is part of a cluster of similar taste receptor genes, which suggests that it may have evolved through a process of gene duplication. The gene is expressed in the taste buds, where it encodes the TAS2R45 protein.

Clinical significance

Variations in the TAS2R45 gene have been associated with individual differences in taste perception, particularly the perception of bitterness. Some studies have suggested that these variations may influence dietary habits and potentially health outcomes. For example, individuals with certain TAS2R45 gene variants may be more sensitive to the bitter taste of certain foods and therefore less likely to consume them.

See also

• Taste receptor
• Bitter taste receptor
• Gene duplication

References

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