Sucrose intolerance

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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Sucrose intolerance
Synonyms	Congenital sucrase-isomaltase deficiency (CSID), sucrase-isomaltase deficiency
Pronounce	N/A
Specialty	N/A
Symptoms	Diarrhea, abdominal pain, bloating, gas
Complications	N/A
Onset	Childhood
Duration	Chronic
Types	N/A
Causes	Genetic mutation in the sucrase-isomaltase gene
Risks	Family history
Diagnosis	Breath test, stool acidity test, genetic testing
Differential diagnosis	Lactose intolerance, fructose malabsorption, irritable bowel syndrome
Prevention	N/A
Treatment	Dietary management, enzyme replacement therapy
Medication	Sacrosidase
Prognosis	N/A
Frequency	Rare
Deaths	N/A

Sucrose intolerance, also known as congenital sucrase-isomaltase deficiency (CSID), is a condition where an individual lacks the enzyme needed to digest sucrose, a common sugar found in many foods. This enzyme deficiency leads to gastrointestinal symptoms when sucrose is consumed.

Pathophysiology

Sucrose intolerance is caused by a deficiency in the enzyme sucrase-isomaltase, which is responsible for breaking down sucrose into glucose and fructose. This enzyme is located on the brush border of the small intestine. When sucrase-isomaltase is deficient or absent, sucrose cannot be properly digested, leading to symptoms such as diarrhea, abdominal pain, and bloating.

Symptoms

The symptoms of sucrose intolerance can vary in severity and may include:

• Chronic diarrhea
• Abdominal pain and cramping
• Bloating and gas
• Nausea
• Vomiting

These symptoms typically occur after the ingestion of foods containing sucrose.

Diagnosis

Diagnosis of sucrose intolerance can be challenging and often involves a combination of dietary history, symptom assessment, and diagnostic tests. Common diagnostic methods include:

• Breath hydrogen test: Measures hydrogen in the breath after ingestion of sucrose.
• Sucrose tolerance test: Monitors blood glucose levels after sucrose ingestion.
• Genetic testing: Identifies mutations in the sucrase-isomaltase gene.

Management

Management of sucrose intolerance primarily involves dietary modification to limit or avoid sucrose intake. Patients may benefit from:

• Sucrose-free diet: Avoiding foods high in sucrose such as sweets, certain fruits, and processed foods.
• Enzyme replacement therapy: Use of enzyme supplements to aid in the digestion of sucrose.

Prognosis

With appropriate dietary management and enzyme supplementation, individuals with sucrose intolerance can lead normal, healthy lives. Early diagnosis and intervention are crucial to prevent complications and improve quality of life.

See also

• Lactose intolerance
• Fructose malabsorption
• Carbohydrate metabolism