Somatic
Somatic refers to the cells of the body excluding the reproductive cells. They are involved in various functions such as forming the organs, tissues, and other parts of an organism's body.
Overview
Somatic cells are the most common type of cells in multicellular organisms. These cells make up the skin, bones, blood, and connective tissue. In humans, there are approximately 220 types of somatic cells.
The word "somatic" is derived from the Greek word "soma", which means body. Unlike germ cells, which are used to form eggs in females and sperm in males, somatic cells are not involved in sexual reproduction. Instead, they perform functions necessary for an organism's survival and are responsible for the body's everyday functions.
Somatic Cell Characteristics
Somatic cells are diploid, meaning they contain two sets of chromosomes. One set of chromosomes is inherited from the organism's mother, and the other set is inherited from the organism's father.
Somatic cells undergo mitosis, a type of cell division that results in two daughter cells each having the same number and kind of chromosomes as the parent nucleus. This is in contrast to germ cells, which undergo meiosis and result in four daughter cells each with half the number of chromosomes of the parent cell.
Somatic Cell Genetics
Somatic cells contain DNA that is unique to each individual. Changes or mutations in the DNA of somatic cells can lead to various diseases, including cancer. However, because somatic cells do not contribute to the next generation, these mutations are not passed on to offspring.
Somatic Cell Therapy
Somatic cell therapy is a form of gene therapy that involves the manipulation of the DNA in somatic cells to treat or prevent diseases. This can involve replacing a malfunctioning gene, or introducing a new gene into the body to fight disease.
See Also
References
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Contributors: Prab R. Tumpati, MD