Single transverse palmar crease

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Single transverse palmar crease
Single transverse palmar crease
Synonyms	Simian line, Simian crease
Pronounce	N/A
Specialty	N/A
Symptoms	Single line that runs across the palm of the hand
Complications	None directly from the crease itself
Onset	Congenital
Duration	Lifelong
Types	N/A
Causes	Genetic and environmental factors
Risks	Associated with certain chromosomal disorders
Diagnosis	Physical examination
Differential diagnosis	Normal palmar crease pattern
Prevention	N/A
Treatment	None required
Medication	N/A
Prognosis	Generally benign
Frequency	Occurs in approximately 1 in 30 people
Deaths	N/A

Single Transverse Palmar Crease

The Single Transverse Palmar Crease (STPC), also known as a simian crease, is a unique feature where the two major palmar creases (the heart line and head line) are fused into a single line that runs across the palm. Traditionally, this feature is observed in both palms of approximately 1% of the general population but is more commonly unilateral. The presence of an STPC can be a normal variant; however, it is also associated with certain medical conditions and syndromes.

Introduction

A single transverse palmar crease is formed during fetal development, typically by the 12th week of gestation. The crease is made visible by the underlying flexor tendons. In most individuals, the palm has three distinct lines: the heart line, head line, and life line. The STPC occurs when the first two merge into one.

A hand displaying a Single Transverse Palmar Crease.

Clinical Significance

While an STPC can appear in healthy individuals with no other symptoms, its presence is notably higher in certain chromosomal and genetic disorders, making it a point of clinical interest:

Associated Conditions

• Down Syndrome: The most well-known association of STPC is with Down syndrome, where it is present in 45% of individuals.
• Turner Syndrome: A condition affecting females, where one of the X chromosomes is missing or partially missing.
• Noonan Syndrome: A genetic disorder that prevents normal development in various parts of the body.
• Klinefelter Syndrome: A genetic condition affecting males, characterized by an extra X chromosome.

Implications

The presence of a Single Transverse Palmar Crease alone is not diagnostic of any condition, but it can be one of several indicators that suggest further genetic evaluation is warranted, especially if other symptoms or anomalies are present.

Diagnosis and Evaluation

The identification of an STPC is typically made through physical examination. When a single palmar crease is observed, particularly if it is bilateral, healthcare providers may recommend genetic testing or further evaluation to rule out associated syndromes, especially if additional physical or developmental anomalies are noted.

Genetic Counseling

For individuals or families where an STPC is identified, especially in the context of a diagnosed condition, genetic counseling may be offered. Counseling provides information on the inheritance patterns, risks to other family members, and implications for future pregnancies.

External Links

• National Center for Biotechnology Information: Palmar Creases
• CDC: Facts about Down Syndrome

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