Sex-determining region Y protein
Sex-determining region Y protein
The Sex-determining region Y protein (pronounced: /sɛks dɪˈtɜːrmɪnɪŋ ˈriːdʒən waɪ ˈproʊtiːn/), often abbreviated as SRY protein, is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in humans.
Etymology
The term "Sex-determining region Y protein" is derived from its function and location. The "Sex-determining" part refers to its role in determining the sex of an organism, while "region Y" refers to its location on the Y chromosome. The term "protein" is used because it is a protein that performs this function.
Function
The SRY protein plays a crucial role in the differentiation of the gonads into testes, rather than ovaries. It does this by upregulating genes such as SOX9 that promote testes development and downregulating genes that promote ovary development.
Related Terms
- SRY gene: The gene that encodes the SRY protein.
- Y chromosome: The chromosome that carries the SRY gene.
- SOX9: A gene that is upregulated by the SRY protein to promote testes development.
- Gonads: The organs that the SRY protein helps differentiate into testes or ovaries.
See Also
External links
- Medical encyclopedia article on Sex-determining region Y protein
- Wikipedia's article - Sex-determining region Y protein
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