Sesquiterpene lactone

Sesquiterpene lactones are a class of organic compounds that are a subclass of terpenes. They are known for their various bioactive properties, which include anti-inflammatory, antitumor, antiviral, and antibacterial activities.

Structure

Sesquiterpene lactones are characterized by a three-ring structure, which includes a lactone ring. The lactone ring is a cyclic ester that can be found in a variety of different forms, depending on the specific sesquiterpene lactone.

Biosynthesis

The biosynthesis of sesquiterpene lactones is a complex process that involves the mevalonate pathway. This pathway is responsible for the production of all terpenes and terpenoids, including sesquiterpene lactones.

Biological activity

Sesquiterpene lactones have a wide range of biological activities. They are known for their anti-inflammatory properties, which can be attributed to their ability to inhibit the NF-κB pathway. They also have antitumor properties, which are believed to be due to their ability to induce apoptosis in cancer cells. In addition, they have antiviral and antibacterial activities.

Occurrence

Sesquiterpene lactones are found in a variety of plants, particularly in the Asteraceae family. They are also found in the Magnoliaceae and Ranunculaceae families.

See also

• Terpene
• Lactone
• Mevalonate pathway
• NF-κB
• Apoptosis
• Asteraceae
• Magnoliaceae
• Ranunculaceae

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