SUPT20H

SUPT20H (Suppressor of Ty 20 Homolog) is a protein that in humans is encoded by the SUPT20H gene. This protein is part of a larger complex known as the SAGA (Spt-Ada-Gcn5 acetyltransferase) complex, which is involved in transcription regulation and histone acetylation. The SAGA complex plays a crucial role in the modification of chromatin structure, thereby regulating the access of transcription factors to genes. SUPT20H, specifically, has been implicated in various cellular processes, including transcriptional elongation and the repair of DNA damage.

Function

SUPT20H functions as a component of the SAGA complex, which is a multi-subunit complex involved in the acetylation of histones. This modification of histones is essential for the regulation of gene expression by altering chromatin structure, making DNA more accessible to transcription factors. The SAGA complex is also involved in the process of transcriptional elongation, which ensures that the transcription machinery can efficiently synthesize full-length RNA transcripts.

In addition to its role in transcription and chromatin remodeling, SUPT20H has been implicated in the DNA damage response. It is believed that SUPT20H and the SAGA complex can be recruited to sites of DNA damage, where they facilitate the repair process by modifying chromatin structure and allowing access to repair proteins.

Clinical Significance

Alterations in the expression or function of SUPT20H have been associated with various diseases and conditions. Given its role in gene expression and DNA repair, dysregulation of SUPT20H could potentially contribute to the development of cancer, as both processes are critical in maintaining cellular homeostasis and preventing the accumulation of genetic damage. Research is ongoing to further elucidate the specific mechanisms by which SUPT20H may be involved in cancer and other diseases.

Genetic Information

The SUPT20H gene is located on human chromosome 17q21.2. It spans approximately 30 kilobases and consists of multiple exons. The encoded protein, SUPT20H, interacts with other components of the SAGA complex, contributing to its diverse functions in the cell.

Research Directions

Current research on SUPT20H is focused on understanding its precise role in the SAGA complex and how alterations in its function may contribute to disease. Studies are also exploring the potential of targeting SUPT20H and the SAGA complex in therapeutic strategies, particularly for conditions where chromatin modification and transcription regulation are disrupted, such as in certain cancers.

See Also

• Histone acetylation
• Gene expression
• Chromatin
• Transcription (genetics)
• DNA damage (naturally occurring)

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