SLC22A18

SLC22A18 is a gene that in humans is encoded by the SLC22A18 protein. It is also known as the solute carrier family 22 member 18 gene. This gene is located on chromosome 11p15.5, a region which is associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, and lung cancer.

Function

The SLC22A18 gene is part of the solute carrier family, which is a large group of membrane transport proteins that facilitate the movement of a wide variety of solutes across biological membranes. The SLC22A18 protein is thought to play a role in the transport of small molecules.

Clinical significance

Mutations in the SLC22A18 gene have been associated with several types of cancer. The gene is located in a region of chromosome 11 that is often deleted in neuroblastoma, lung cancer, and breast cancer. This has led to the suggestion that SLC22A18 may function as a tumor suppressor gene.

Research

Research into the SLC22A18 gene and its associated protein is ongoing. Current areas of investigation include the role of the gene in cancer development and progression, and its potential as a target for new cancer therapies.

See also

• Solute carrier family
• Tumor suppressor gene
• Chromosome 11 (human)

References

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